Nature Materials, volume 2, issue 9, pages 630-638

Self-assembled nanoscale biosensors based on quantum dot FRET donors

Igor L Medintz ¹

Aaron R Clapp ²

Hedi Mattoussi ²

Ellen R. Goldman ¹

Brent Fisher ³

J. Matthew Mauro ^{1, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

Center for Bio/Molecular Science and Engineering, Code 6910, US Naval Research Laboratory, Washington, USA |

Division of Optical Sciences, Code 5611, US Naval Research Laboratory, Washington, USA |

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, USA |

⁴

Molecular Probes Inc., Eugene, USA |

Publication type: Journal Article

Publication date: 2003-08-24

Springer Nature

Journal: Nature Materials

Quartile SCImago

Quartile WOS

Impact factor: 41.2

ISSN: 14761122, 14764660

DOI: 10.1038/nmat961

Copy DOI

General Chemistry

Condensed Matter Physics

General Materials Science

Mechanical Engineering

Mechanics of Materials

Abstract

The potential of luminescent semiconductor quantum dots (QDs) to enable development of hybrid inorganic-bioreceptor sensing materials has remained largely unrealized. We report the design, formation and testing of QD–protein assemblies that function as chemical sensors. In these assemblies, multiple copies of Escherichia coli maltose-binding protein (MBP) coordinate to each QD by a C-terminal oligohistidine segment and function as sugar receptors. Sensors are self-assembled in solution in a controllable manner. In one configuration, a β-cyclodextrin-QSY9 dark quencher conjugate bound in the MBP saccharide binding site results in fluorescence resonance energy-transfer (FRET) quenching of QD photoluminescence. Added maltose displaces the β-cyclodextrin-QSY9, and QD photoluminescence increases in a systematic manner. A second maltose sensor assembly consists of QDs coupled with Cy3-labelled MBP bound to β-cyclodextrin-Cy3.5. In this case, the QD donor drives sensor function through a two-step FRET mechanism that overcomes inherent QD donor–acceptor distance limitations. Quantum dot–biomolecule assemblies constructed using these methods may facilitate development of new hybrid sensing materials.

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	10 20 30 40 50 60
Journal of Physical Chemistry C	Journal of Physical Chemistry C, 59, 4.26% Journal of Physical Chemistry C 59 publications, 4.26%
Journal of the American Chemical Society	Journal of the American Chemical Society, 49, 3.54% Journal of the American Chemical Society 49 publications, 3.54%
Analytical Chemistry	Analytical Chemistry, 31, 2.24% Analytical Chemistry 31 publications, 2.24%
ACS Nano	ACS Nano, 30, 2.16% ACS Nano 30 publications, 2.16%
Nano Letters	Nano Letters, 29, 2.09% Nano Letters 29 publications, 2.09%
Biosensors and Bioelectronics	Biosensors and Bioelectronics, 26, 1.88% Biosensors and Bioelectronics 26 publications, 1.88%
Chemical Communications	Chemical Communications, 25, 1.8% Chemical Communications 25 publications, 1.8%
Small	Small, 21, 1.52% Small 21 publications, 1.52%
RSC Advances	RSC Advances, 21, 1.52% RSC Advances 21 publications, 1.52%
Chemical Reviews	Chemical Reviews, 20, 1.44% Chemical Reviews 20 publications, 1.44%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 20, 1.44% Angewandte Chemie - International Edition 20 publications, 1.44%
Angewandte Chemie	Angewandte Chemie, 20, 1.44% Angewandte Chemie 20 publications, 1.44%
ACS applied materials & interfaces	ACS applied materials & interfaces, 20, 1.44% ACS applied materials & interfaces 20 publications, 1.44%
Analytical and Bioanalytical Chemistry	Analytical and Bioanalytical Chemistry, 17, 1.23% Analytical and Bioanalytical Chemistry 17 publications, 1.23%
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Nanoscale	Nanoscale, 16, 1.15% Nanoscale 16 publications, 1.15%
Applied Physics Letters	Applied Physics Letters, 13, 0.94% Applied Physics Letters 13 publications, 0.94%
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Chemistry of Materials	Chemistry of Materials, 13, 0.94% Chemistry of Materials 13 publications, 0.94%
Bioconjugate Chemistry	Bioconjugate Chemistry, 13, 0.94% Bioconjugate Chemistry 13 publications, 0.94%
Journal of Materials Chemistry A	Journal of Materials Chemistry A, 13, 0.94% Journal of Materials Chemistry A 13 publications, 0.94%
Nanotechnology	Nanotechnology, 12, 0.87% Nanotechnology 12 publications, 0.87%
Journal of Luminescence	Journal of Luminescence, 11, 0.79% Journal of Luminescence 11 publications, 0.79%
Journal of Fluorescence	Journal of Fluorescence, 11, 0.79% Journal of Fluorescence 11 publications, 0.79%
Sensors and Actuators, B: Chemical	Sensors and Actuators, B: Chemical, 11, 0.79% Sensors and Actuators, B: Chemical 11 publications, 0.79%
Chemical Society Reviews	Chemical Society Reviews, 11, 0.79% Chemical Society Reviews 11 publications, 0.79%
Physical Chemistry Chemical Physics	Physical Chemistry Chemical Physics, 11, 0.79% Physical Chemistry Chemical Physics 11 publications, 0.79%
	10 20 30 40 50 60

Citations by publishers

	50 100 150 200 250 300 350
American Chemical Society (ACS)	American Chemical Society (ACS), 314, 22.66% American Chemical Society (ACS) 314 publications, 22.66%
Elsevier	Elsevier, 249, 17.97% Elsevier 249 publications, 17.97%
Wiley	Wiley, 188, 13.56% Wiley 188 publications, 13.56%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 152, 10.97% Royal Society of Chemistry (RSC) 152 publications, 10.97%
Springer Nature	Springer Nature, 130, 9.38% Springer Nature 130 publications, 9.38%
IOP Publishing	IOP Publishing, 38, 2.74% IOP Publishing 38 publications, 2.74%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 30, 2.16% Multidisciplinary Digital Publishing Institute (MDPI) 30 publications, 2.16%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 23, 1.66% American Institute of Physics (AIP) 23 publications, 1.66%
Taylor & Francis	Taylor & Francis, 23, 1.66% Taylor & Francis 23 publications, 1.66%
SPIE	SPIE, 15, 1.08% SPIE 15 publications, 1.08%
IEEE	IEEE, 15, 1.08% IEEE 15 publications, 1.08%
American Physical Society (APS)	American Physical Society (APS), 14, 1.01% American Physical Society (APS) 14 publications, 1.01%
Optical Society of America	Optical Society of America, 9, 0.65% Optical Society of America 9 publications, 0.65%
Pleiades Publishing	Pleiades Publishing, 8, 0.58% Pleiades Publishing 8 publications, 0.58%
Future Medicine	Future Medicine, 6, 0.43% Future Medicine 6 publications, 0.43%
Hindawi Limited	Hindawi Limited, 5, 0.36% Hindawi Limited 5 publications, 0.36%
SAGE	SAGE, 4, 0.29% SAGE 4 publications, 0.29%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 4, 0.29% Proceedings of the National Academy of Sciences (PNAS) 4 publications, 0.29%
Annual Reviews	Annual Reviews, 4, 0.29% Annual Reviews 4 publications, 0.29%
World Scientific	World Scientific, 3, 0.22% World Scientific 3 publications, 0.22%
Frontiers Media S.A.	Frontiers Media S.A., 3, 0.22% Frontiers Media S.A. 3 publications, 0.22%
Materials Research Society	Materials Research Society, 3, 0.22% Materials Research Society 3 publications, 0.22%
Mary Ann Liebert	Mary Ann Liebert, 2, 0.14% Mary Ann Liebert 2 publications, 0.14%
Diabetes Technology Society	Diabetes Technology Society, 2, 0.14% Diabetes Technology Society 2 publications, 0.14%
Oxford University Press	Oxford University Press, 2, 0.14% Oxford University Press 2 publications, 0.14%
Walter de Gruyter	Walter de Gruyter, 2, 0.14% Walter de Gruyter 2 publications, 0.14%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 2, 0.14% Cold Spring Harbor Laboratory 2 publications, 0.14%
IGI Global	IGI Global, 2, 0.14% IGI Global 2 publications, 0.14%
Wolters Kluwer Health	Wolters Kluwer Health, 1, 0.07% Wolters Kluwer Health 1 publication, 0.07%
	50 100 150 200 250 300 350

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Medintz I. L. et al. Self-assembled nanoscale biosensors based on quantum dot FRET donors // Nature Materials. 2003. Vol. 2. No. 9. pp. 630-638.

GOST all authors (up to 50) Copy

Medintz I. L., Clapp A. R., Mattoussi H., Goldman E. R., Fisher B., Mauro J. M. Self-assembled nanoscale biosensors based on quantum dot FRET donors // Nature Materials. 2003. Vol. 2. No. 9. pp. 630-638.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nmat961

UR - https://doi.org/10.1038/nmat961

TI - Self-assembled nanoscale biosensors based on quantum dot FRET donors

T2 - Nature Materials

AU - Medintz, Igor L

AU - Clapp, Aaron R

AU - Mattoussi, Hedi

AU - Goldman, Ellen R.

AU - Fisher, Brent

AU - Mauro, J. Matthew

PY - 2003

DA - 2003/08/24 00:00:00

PB - Springer Nature

SP - 630-638

IS - 9

VL - 2

SN - 1476-1122

SN - 1476-4660

ER -

BibTex |

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BibTex Copy

@article{2003_Medintz,

author = {Igor L Medintz and Aaron R Clapp and Hedi Mattoussi and Ellen R. Goldman and Brent Fisher and J. Matthew Mauro},

title = {Self-assembled nanoscale biosensors based on quantum dot FRET donors},

journal = {Nature Materials},

year = {2003},

volume = {2},

publisher = {Springer Nature},

month = {aug},

url = {https://doi.org/10.1038/nmat961},

number = {9},

pages = {630--638},

doi = {10.1038/nmat961}

}

MLA

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MLA Copy

Medintz, Igor L., et al. “Self-assembled nanoscale biosensors based on quantum dot FRET donors.” Nature Materials, vol. 2, no. 9, Aug. 2003, pp. 630-638. https://doi.org/10.1038/nmat961.

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Publisher

Springer Nature

Journal

Nature Materials

Quartile SCImago

Quartile WOS

Impact factor

41.2

ISSN

14761122 (Print)
14764660 (Electronic)