Nature Nanotechnology

, том 7 , издание 9 , страницы 602-608

Single-protein nanomechanical mass spectrometry in real time

Тип публикации: Journal Article

Дата публикации: 2012-08-26

Springer Nature

Nature Nanotechnology

scimago Q1

wos Q1

БС1

SJR: 14.612

CiteScore: 62.2

Impact factor: 34.9

ISSN: 17483387, 17483395

DOI: 10.1038/nnano.2012.119

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PubMed ID: 22922541

Atomic and Molecular Physics, and Optics

Condensed Matter Physics

General Materials Science

Electrical and Electronic Engineering

Bioengineering

Biomedical Engineering

Краткое описание

Nanoelectromechanical systems (NEMS) resonators can detect mass with exceptional sensitivity. Previously, mass spectra from several hundred adsorption events were assembled in NEMS-based mass spectrometry using statistical analysis. Here, we report the first realization of single-molecule NEMS-based mass spectrometry in real time. As each molecule in the sample adsorbs on the resonator, its mass and position of adsorption are determined by continuously tracking two driven vibrational modes of the device. We demonstrate the potential of multimode NEMS-based mass spectrometry by analysing IgM antibody complexes in real time. NEMS-based mass spectrometry is a unique and promising new form of mass spectrometry: it can resolve neutral species, provide a resolving power that increases markedly for very large masses, and allow the acquisition of spectra, molecule-by-molecule, in real time. The potential of single-protein NEMS-based mass spectrometry is demonstrated by analysing IgM antibody complexes in real time.

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Hanay M. S. et al. Single-protein nanomechanical mass spectrometry in real time // Nature Nanotechnology. 2012. Vol. 7. No. 9. pp. 602-608.

ГОСТ со всеми авторами (до 50) Скопировать

Hanay M. S., Kelber S., Naik A. K., Chi D., Hentz S., Bullard E. C., Colinet E., Duraffourg L., Roukes M. L. Single-protein nanomechanical mass spectrometry in real time // Nature Nanotechnology. 2012. Vol. 7. No. 9. pp. 602-608.

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TY - JOUR

DO - 10.1038/nnano.2012.119

UR - https://doi.org/10.1038/nnano.2012.119

TI - Single-protein nanomechanical mass spectrometry in real time

T2 - Nature Nanotechnology

AU - Hanay, M S

AU - Kelber, S.

AU - Naik, A. K.

AU - Chi, D

AU - Hentz, S

AU - Bullard, E. C.

AU - Colinet, E

AU - Duraffourg, L.

AU - Roukes, M L

PY - 2012

DA - 2012/08/26

PB - Springer Nature

SP - 602-608

IS - 9

VL - 7

PMID - 22922541

SN - 1748-3387

SN - 1748-3395

ER -

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@article{2012_Hanay,

author = {M S Hanay and S. Kelber and A. K. Naik and D Chi and S Hentz and E. C. Bullard and E Colinet and L. Duraffourg and M L Roukes},

title = {Single-protein nanomechanical mass spectrometry in real time},

journal = {Nature Nanotechnology},

year = {2012},

volume = {7},

publisher = {Springer Nature},

month = {aug},

url = {https://doi.org/10.1038/nnano.2012.119},

number = {9},

pages = {602--608},

doi = {10.1038/nnano.2012.119}

}

MLA

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Hanay, M. S., et al. “Single-protein nanomechanical mass spectrometry in real time.” Nature Nanotechnology, vol. 7, no. 9, Aug. 2012, pp. 602-608. https://doi.org/10.1038/nnano.2012.119.

Издатель

Springer Nature

Журнал

Nature Nanotechnology

scimago Q1

wos Q1

БС1

SJR

14.612

CiteScore

62.2

Impact factor

34.9

ISSN

17483387 (Print)

17483395 (Electronic)