Open Access
Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer
Mikhail Arbatskiy
2
,
Vladimir Popov
1, 2
,
Olga Grigorieva
1
,
Maksim Vigovskiy
1, 2
,
Zaytsev Ivan
2
,
Ekaterina Novoseletskaya
1
,
Georgy Sagaradze
1, 2
,
Natalia Danilova
2, 3
,
Pavel Malkov
2, 3
,
Cherniaev Andrey
4, 5
,
Maria Samsonova
4, 5
,
Maxim Karagyaur
1, 2
,
Tolstoluzhinskaya Anastasiya
1, 2
,
Uliana Dyachkova
2
,
Zhanna Akopyan
1, 2
,
Vsevolod Tkachuk
1, 2
,
Natalia Kalinina
2
,
Efimenko Anastasiya
1, 2
Тип публикации: Journal Article
Дата публикации: 2023-07-03
scimago Q1
wos Q1
БС1
SJR: 4.001
CiteScore: 17.2
Impact factor: 12.9
ISSN: 12263613, 20966413, 20926413
PubMed ID:
37394579
Biochemistry
Molecular Biology
Clinical Biochemistry
Molecular Medicine
Краткое описание
To date, pulmonary fibrosis remains an unmet medical need. In this study, we evaluated the potency of mesenchymal stromal cell (MSC) secretome components to prevent pulmonary fibrosis development and facilitate fibrosis resolution. Surprisingly, the intratracheal application of extracellular vesicles (MSC-EVs) or the vesicle-depleted secretome fraction (MSC-SF) was not able to prevent lung fibrosis when applied immediately after the injury caused by bleomycin instillation in mice. However, MSC-EV administration induced the resolution of established pulmonary fibrosis, whereas the vesicle-depleted fraction did not. The application of MSC-EVs caused a decrease in the numbers of myofibroblasts and FAPa+ progenitors without affecting their apoptosis. Such a decrease likely occurred due to their dedifferentiation caused by microRNA (miR) transfer by MSC-EVs. Using a murine model of bleomycin-induced pulmonary fibrosis, we confirmed the contribution of specific miRs (miR-29c and miR-129) to the antifibrotic effect of MSC-EVs. Our study provides novel insights into possible antifibrotic therapy based on the use of the vesicle-enriched fraction of the MSC secretome.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Топ-30
Журналы
|
1
2
3
|
|
|
International Journal of Molecular Sciences
3 публикации, 9.38%
|
|
|
International Journal of Nanomedicine
2 публикации, 6.25%
|
|
|
Non-coding RNA
1 публикация, 3.13%
|
|
|
Biomolecules
1 публикация, 3.13%
|
|
|
Stem Cell Research and Therapy
1 публикация, 3.13%
|
|
|
Journal of Advanced Research
1 публикация, 3.13%
|
|
|
Respiratory Research
1 публикация, 3.13%
|
|
|
Cell Biology International
1 публикация, 3.13%
|
|
|
Animals
1 публикация, 3.13%
|
|
|
Critical Reviews in Oncology/Hematology
1 публикация, 3.13%
|
|
|
Journal of Biochemical and Molecular Toxicology
1 публикация, 3.13%
|
|
|
Biochemical and Biophysical Research Communications
1 публикация, 3.13%
|
|
|
Frontiers in Cell and Developmental Biology
1 публикация, 3.13%
|
|
|
Nanoindustry Russia
1 публикация, 3.13%
|
|
|
Arkhiv Patologii
1 публикация, 3.13%
|
|
|
FASEB Journal
1 публикация, 3.13%
|
|
|
Cell Transplantation
1 публикация, 3.13%
|
|
|
Bioactive Materials
1 публикация, 3.13%
|
|
|
Life Sciences
1 публикация, 3.13%
|
|
|
Bulletin of Experimental Biology and Medicine
1 публикация, 3.13%
|
|
|
International Immunopharmacology
1 публикация, 3.13%
|
|
|
Health Science Reports
1 публикация, 3.13%
|
|
|
Drug development & registration
1 публикация, 3.13%
|
|
|
Non-coding RNA Research
1 публикация, 3.13%
|
|
|
Inflammation and Regeneration
1 публикация, 3.13%
|
|
|
International Journal of Biological Macromolecules
1 публикация, 3.13%
|
|
|
Physiological Reviews
1 публикация, 3.13%
|
|
|
Frontiers in Bioengineering and Biotechnology
1 публикация, 3.13%
|
|
|
1
2
3
|
Издатели
|
1
2
3
4
5
6
7
8
|
|
|
Elsevier
8 публикаций, 25%
|
|
|
MDPI
6 публикаций, 18.75%
|
|
|
Springer Nature
4 публикации, 12.5%
|
|
|
Wiley
4 публикации, 12.5%
|
|
|
Frontiers Media S.A.
2 публикации, 6.25%
|
|
|
Taylor & Francis
2 публикации, 6.25%
|
|
|
Technosphera JSC
1 публикация, 3.13%
|
|
|
Media Sphere Publishing House
1 публикация, 3.13%
|
|
|
SAGE
1 публикация, 3.13%
|
|
|
Center of Pharmaceutical Analytics Ltd
1 публикация, 3.13%
|
|
|
American Physiological Society
1 публикация, 3.13%
|
|
|
1
2
3
4
5
6
7
8
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
32
Всего цитирований:
32
Цитирований c 2024:
27
(84.38%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Basalova N. et al. Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer // Experimental and Molecular Medicine. 2023. Vol. 55. No. 7. pp. 1399-1412.
ГОСТ со всеми авторами (до 50)
Скопировать
Basalova N., Arbatskiy M., Popov V., Grigorieva O., Vigovskiy M., Ivan Z., Novoseletskaya E., Sagaradze G., Danilova N., Malkov P., Andrey C., Samsonova M., Karagyaur M., Anastasiya T., Dyachkova U., Akopyan Z., Tkachuk V., Kalinina N., Anastasiya E. Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer // Experimental and Molecular Medicine. 2023. Vol. 55. No. 7. pp. 1399-1412.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1038/s12276-023-01017-w
UR - https://doi.org/10.1038/s12276-023-01017-w
TI - Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer
T2 - Experimental and Molecular Medicine
AU - Basalova, Nataliya
AU - Arbatskiy, Mikhail
AU - Popov, Vladimir
AU - Grigorieva, Olga
AU - Vigovskiy, Maksim
AU - Ivan, Zaytsev
AU - Novoseletskaya, Ekaterina
AU - Sagaradze, Georgy
AU - Danilova, Natalia
AU - Malkov, Pavel
AU - Andrey, Cherniaev
AU - Samsonova, Maria
AU - Karagyaur, Maxim
AU - Anastasiya, Tolstoluzhinskaya
AU - Dyachkova, Uliana
AU - Akopyan, Zhanna
AU - Tkachuk, Vsevolod
AU - Kalinina, Natalia
AU - Anastasiya, Efimenko
PY - 2023
DA - 2023/07/03
PB - Springer Nature
SP - 1399-1412
IS - 7
VL - 55
PMID - 37394579
SN - 1226-3613
SN - 2096-6413
SN - 2092-6413
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2023_Basalova,
author = {Nataliya Basalova and Mikhail Arbatskiy and Vladimir Popov and Olga Grigorieva and Maksim Vigovskiy and Zaytsev Ivan and Ekaterina Novoseletskaya and Georgy Sagaradze and Natalia Danilova and Pavel Malkov and Cherniaev Andrey and Maria Samsonova and Maxim Karagyaur and Tolstoluzhinskaya Anastasiya and Uliana Dyachkova and Zhanna Akopyan and Vsevolod Tkachuk and Natalia Kalinina and Efimenko Anastasiya},
title = {Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer},
journal = {Experimental and Molecular Medicine},
year = {2023},
volume = {55},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1038/s12276-023-01017-w},
number = {7},
pages = {1399--1412},
doi = {10.1038/s12276-023-01017-w}
}
Цитировать
MLA
Скопировать
Basalova, Nataliya, et al. “Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer.” Experimental and Molecular Medicine, vol. 55, no. 7, Jul. 2023, pp. 1399-1412. https://doi.org/10.1038/s12276-023-01017-w.