Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2
Masayuki Igarashi
1
,
Ryuichi SAWA
1
,
Maya Umekita
1
,
Masaki Hatano
1
,
Rie Arisaka
1
,
Chigusa Hayashi
1
,
Yoshimasa Ishizaki
1
,
masato suzuki
2
,
Chiaki Kato
3
1
Institute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Japan
|
Publication type: Journal Article
Publication date: 2021-02-03
scimago Q3
wos Q2
SJR: 0.481
CiteScore: 4.8
Impact factor: 2.7
ISSN: 00218820, 18811469
PubMed ID:
33531630
Drug Discovery
Pharmacology
Abstract
A Nonomuraea sp. strain MM565M-173N2 was isolated from deep-sea sediment off the Sanriku coast, and new antibiotics were evaluated against carbapenem-resistant Enterobacteriaceae (CRE), which is a problematic group of bacteria because of their antimicrobial resistance. From 220 l of fermented broth from strain MM565M-173N2, we isolated four new antibiotics by gel filtration and HPLC, designated as sealutomicins A (1.8 mg), B (1.5 mg), C (0.8 mg), and D (0.8 mg). Their structures were determined from MS, NMR, and CD spectra. Sealutomicin A was found to be a new enediyne antibiotic, while sealutomicins B–D were aromatized products from sealutomicin A. Sealutomicin A showed strong antibacterial activity (MIC 0.05–0.2 μg ml−1) against CRE.
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Total citations:
33
Citations from 2025:
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(18.18%)
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GOST
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Igarashi M. et al. Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2 // Journal of Antibiotics. 2021. Vol. 74. No. 5. pp. 291-299.
GOST all authors (up to 50)
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Igarashi M., SAWA R., Umekita M., Hatano M., Arisaka R., Hayashi C., Ishizaki Y., suzuki M., Kato C. Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2 // Journal of Antibiotics. 2021. Vol. 74. No. 5. pp. 291-299.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1038/s41429-020-00402-1
UR - https://www.nature.com/articles/s41429-020-00402-1
TI - Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2
T2 - Journal of Antibiotics
AU - Igarashi, Masayuki
AU - SAWA, Ryuichi
AU - Umekita, Maya
AU - Hatano, Masaki
AU - Arisaka, Rie
AU - Hayashi, Chigusa
AU - Ishizaki, Yoshimasa
AU - suzuki, masato
AU - Kato, Chiaki
PY - 2021
DA - 2021/02/03
PB - Springer Nature
SP - 291-299
IS - 5
VL - 74
PMID - 33531630
SN - 0021-8820
SN - 1881-1469
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Igarashi,
author = {Masayuki Igarashi and Ryuichi SAWA and Maya Umekita and Masaki Hatano and Rie Arisaka and Chigusa Hayashi and Yoshimasa Ishizaki and masato suzuki and Chiaki Kato},
title = {Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2},
journal = {Journal of Antibiotics},
year = {2021},
volume = {74},
publisher = {Springer Nature},
month = {feb},
url = {https://www.nature.com/articles/s41429-020-00402-1},
number = {5},
pages = {291--299},
doi = {10.1038/s41429-020-00402-1}
}
Cite this
MLA
Copy
Igarashi, Masayuki, et al. “Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2.” Journal of Antibiotics, vol. 74, no. 5, Feb. 2021, pp. 291-299. https://www.nature.com/articles/s41429-020-00402-1.