Open Access
Nature Communications, volume 9, issue 1, publication number 2625
Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols
Yuchao Zhu
1
,
Kaimeng Huang
1
,
Jun Pan
1
,
Qiu Xu
1
,
Xiao Luo
1
,
Qixue Qin
1
,
Jialiang Wei
1
,
Xiaojin Wen
1
,
Lizhi Zhang
1
,
Ning Jiao
1, 2
2
State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai, China
|
Publication type: Journal Article
Publication date: 2018-07-06
General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy
Abstract
Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp3-H bond functionalization of abundant and inexpensive aliphatic alcohols. Valuable oximonitrile substituted alcohols are easily obtained by using well-designed sulphonyl reagents under simple and mild conditions. This protocol realizes the challenging δ-selective C–C bond formation of simple alkanols. Aliphatic alcohols usually require pre-activation for successful functionalization of their carbon chain. Here, the authors report a silver-catalyzed δ-selective functionalization of aliphatic alcohols via Csp3-H bond cleavage under mild conditions without the need of substrate pre-activation.
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GOST
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Zhu Y. et al. Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols // Nature Communications. 2018. Vol. 9. No. 1. 2625
GOST all authors (up to 50)
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Zhu Y., Huang K., Pan J., Xu Q., Luo X., Qin Q., Wei J., Wen X., Zhang L., Jiao N. Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols // Nature Communications. 2018. Vol. 9. No. 1. 2625
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TY - JOUR
DO - 10.1038/s41467-018-05014-w
UR - https://doi.org/10.1038/s41467-018-05014-w
TI - Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols
T2 - Nature Communications
AU - Zhu, Yuchao
AU - Huang, Kaimeng
AU - Pan, Jun
AU - Xu, Qiu
AU - Luo, Xiao
AU - Qin, Qixue
AU - Wei, Jialiang
AU - Wen, Xiaojin
AU - Zhang, Lizhi
AU - Jiao, Ning
PY - 2018
DA - 2018/07/06
PB - Springer Nature
IS - 1
VL - 9
SN - 2041-1723
ER -
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@article{2018_Zhu,
author = {Yuchao Zhu and Kaimeng Huang and Jun Pan and Qiu Xu and Xiao Luo and Qixue Qin and Jialiang Wei and Xiaojin Wen and Lizhi Zhang and Ning Jiao},
title = {Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols},
journal = {Nature Communications},
year = {2018},
volume = {9},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1038/s41467-018-05014-w},
number = {1},
doi = {10.1038/s41467-018-05014-w}
}