Open Access
Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response
Wojciech Barczak
1
,
Simon Mark Carr
1
,
GENG LIU
1
,
Shonagh Munro
2
,
Annalisa Nicastri
3
,
Lian Li
4
,
Claire Hutchings
4
,
Nicola Ternette
3
,
Paul Klenerman
4
,
2
Argonaut Therapeutics Ltd, Oxford Science Park, Oxford, UK
|
Тип публикации: Journal Article
Дата публикации: 2023-02-25
scimago Q1
wos Q1
БС1
SJR: 4.761
CiteScore: 23.4
Impact factor: 15.7
ISSN: 20411723
PubMed ID:
36841868
General Chemistry
General Biochemistry, Genetics and Molecular Biology
Multidisciplinary
General Physics and Astronomy
Краткое описание
Protein arginine methyltransferase (PRMT) 5 is over-expressed in a variety of cancers and the master transcription regulator E2F1 is an important methylation target. We have explored the role of PRMT5 and E2F1 in regulating the non-coding genome and report here a striking effect on long non-coding (lnc) RNA gene expression. Moreover, many MHC class I protein-associated peptides were derived from small open reading frames in the lncRNA genes. Pharmacological inhibition of PRMT5 or adjusting E2F1 levels qualitatively altered the repertoire of lncRNA-derived peptide antigens displayed by tumour cells. When presented to the immune system as either ex vivo-loaded dendritic cells or expressed from a viral vector, lncRNA-derived peptides drove a potent antigen-specific CD8 T lymphocyte response, which translated into a significant delay in tumour growth. Thus, lncRNA genes encode immunogenic peptides that can be deployed as a cancer vaccine.
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ГОСТ |
RIS |
BibTex
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ГОСТ
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Barczak W. et al. Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response // Nature Communications. 2023. Vol. 14. No. 1. 1078
ГОСТ со всеми авторами (до 50)
Скопировать
Barczak W., Carr S. M., LIU G., Munro S., Nicastri A., Li L., Hutchings C., Ternette N., Klenerman P., Kanapin A., Samsonova A., La Thangue N. B. Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response // Nature Communications. 2023. Vol. 14. No. 1. 1078
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RIS
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TY - JOUR
DO - 10.1038/s41467-023-36826-0
UR - https://doi.org/10.1038/s41467-023-36826-0
TI - Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response
T2 - Nature Communications
AU - Barczak, Wojciech
AU - Carr, Simon Mark
AU - LIU, GENG
AU - Munro, Shonagh
AU - Nicastri, Annalisa
AU - Li, Lian
AU - Hutchings, Claire
AU - Ternette, Nicola
AU - Klenerman, Paul
AU - Kanapin, Alexander
AU - Samsonova, Anastasia
AU - La Thangue, Nick B.
PY - 2023
DA - 2023/02/25
PB - Springer Nature
IS - 1
VL - 14
PMID - 36841868
SN - 2041-1723
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2023_Barczak,
author = {Wojciech Barczak and Simon Mark Carr and GENG LIU and Shonagh Munro and Annalisa Nicastri and Lian Li and Claire Hutchings and Nicola Ternette and Paul Klenerman and Alexander Kanapin and Anastasia Samsonova and Nick B. La Thangue},
title = {Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response},
journal = {Nature Communications},
year = {2023},
volume = {14},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1038/s41467-023-36826-0},
number = {1},
pages = {1078},
doi = {10.1038/s41467-023-36826-0}
}