Open Access
Nature Communications, volume 14, issue 1, publication number 1258
Zebrafish pigment cells develop directly from persistent highly multipotent progenitors
SUBKHANKULOVA Tatiana
1
,
Camargo Sosa Karen
1
,
Урошлев Л. А.
2
,
Nikaido Masataka
1, 3
,
Shriever Noah
1
,
Kasianov Artem S
2, 4, 5
,
Yang Xueyan
1, 6
,
Rodrigues Frederico S L M
1
,
Carney Thomas F.
1, 7
,
Bavister Gemma
1
,
Schwetlick Hartmut
8
,
Dawes J. H. P.
8
,
Rocco Andrea
9, 10
,
Makeev Vsevolod J.
2, 5, 11
,
Kelsh Robert N.
1
1
Department of Life Sciences, University of Bath, Claverton Down, Bath, UK
|
3
Graduate School of Science, University of Hyogo, Ako-gun, Japan
|
8
Department of Mathematical Sciences, University of Bath, Claverton Down, Bath, UK
|
9
Department of Physics, FEPS, University of Surrey, Guildford, UK
|
10
Department of Microbial Sciences, FHMS, University of Surrey, Guildford, UK
|
Publication type: Journal Article
Publication date: 2023-03-06
Journal:
Nature Communications
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.6
ISSN: 20411723
General Chemistry
General Biochemistry, Genetics and Molecular Biology
Multidisciplinary
General Physics and Astronomy
Abstract
Neural crest cells are highly multipotent stem cells, but it remains unclear how their fate restriction to specific fates occurs. The direct fate restriction model hypothesises that migrating cells maintain full multipotency, whilst progressive fate restriction envisages fully multipotent cells transitioning to partially-restricted intermediates before committing to individual fates. Using zebrafish pigment cell development as a model, we show applying NanoString hybridization single cell transcriptional profiling and RNAscope in situ hybridization that neural crest cells retain broad multipotency throughout migration and even in post-migratory cells in vivo, with no evidence for partially-restricted intermediates. We find that leukocyte tyrosine kinase early expression marks a multipotent stage, with signalling driving iridophore differentiation through repression of fate-specific transcription factors for other fates. We reconcile the direct and progressive fate restriction models by proposing that pigment cell development occurs directly, but dynamically, from a highly multipotent state, consistent with our recently-proposed Cyclical Fate Restriction model.
Citations by journals
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1
2
|
|
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eLife
|
eLife
2 publications, 22.22%
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|
Genes
|
Genes
1 publication, 11.11%
|
|
Nature Communications
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Nature Communications
1 publication, 11.11%
|
|
Development (Cambridge)
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Development (Cambridge)
1 publication, 11.11%
|
|
Frontiers in Marine Science
|
Frontiers in Marine Science
1 publication, 11.11%
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|
Pigment Cell and Melanoma Research
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Pigment Cell and Melanoma Research
1 publication, 11.11%
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|
1
2
|
Citations by publishers
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1
2
|
|
|
eLife Sciences Publications
|
eLife Sciences Publications
2 publications, 22.22%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 11.11%
|
|
Springer Nature
|
Springer Nature
1 publication, 11.11%
|
|
The Company of Biologists
|
The Company of Biologists
1 publication, 11.11%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 11.11%
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|
Wiley
|
Wiley
1 publication, 11.11%
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|
1
2
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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SUBKHANKULOVA T. et al. Zebrafish pigment cells develop directly from persistent highly multipotent progenitors // Nature Communications. 2023. Vol. 14. No. 1. 1258
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SUBKHANKULOVA T., Camargo Sosa K., Урошлев Л. А., Nikaido M., Shriever N., Kasianov A. S., Yang X., Rodrigues F. S. L. M., Carney T. F., Bavister G., Schwetlick H., Dawes J. H. P., Rocco A., Makeev V. J., Kelsh R. N. Zebrafish pigment cells develop directly from persistent highly multipotent progenitors // Nature Communications. 2023. Vol. 14. No. 1. 1258
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TY - JOUR
DO - 10.1038/s41467-023-36876-4
UR - https://doi.org/10.1038%2Fs41467-023-36876-4
TI - Zebrafish pigment cells develop directly from persistent highly multipotent progenitors
T2 - Nature Communications
AU - SUBKHANKULOVA, Tatiana
AU - Camargo Sosa, Karen
AU - Урошлев, Л. А.
AU - Nikaido, Masataka
AU - Shriever, Noah
AU - Kasianov, Artem S
AU - Yang, Xueyan
AU - Rodrigues, Frederico S L M
AU - Carney, Thomas F.
AU - Bavister, Gemma
AU - Schwetlick, Hartmut
AU - Dawes, J. H. P.
AU - Rocco, Andrea
AU - Makeev, Vsevolod J.
AU - Kelsh, Robert N.
PY - 2023
DA - 2023/03/06 00:00:00
PB - Springer Nature
IS - 1
VL - 14
SN - 2041-1723
ER -
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@article{2023_SUBKHANKULOVA,
author = {Tatiana SUBKHANKULOVA and Karen Camargo Sosa and Л. А. Урошлев and Masataka Nikaido and Noah Shriever and Artem S Kasianov and Xueyan Yang and Frederico S L M Rodrigues and Thomas F. Carney and Gemma Bavister and Hartmut Schwetlick and J. H. P. Dawes and Andrea Rocco and Vsevolod J. Makeev and Robert N. Kelsh},
title = {Zebrafish pigment cells develop directly from persistent highly multipotent progenitors},
journal = {Nature Communications},
year = {2023},
volume = {14},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1038%2Fs41467-023-36876-4},
number = {1},
doi = {10.1038/s41467-023-36876-4}
}