Nature Neuroscience, volume 26, issue 6, pages 1032-1041
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Moliner Rafael
1, 2
,
Girych Mykhailo
3
,
Brunello Cecilia
2
,
Kovaleva Vera
4
,
Biojone Caroline
2, 5, 6
,
Enkavi Giray
3
,
Antenucci Lina
7
,
Kot Erik F
8, 9
,
Goncharuk Sergey A.
8, 9
,
Kaurinkoski Katja
2
,
Kuutti Mirjami
2
,
Fred Senem Merve
2
,
Elsilä Lauri V
1
,
Sakson Sven
4
,
Diniz Cassiano
10
,
Seiffert Nina
2
,
Rubiolo Anna
11
,
Haapaniemi Hele
2
,
Meshi Elsa
12
,
Nagaeva Elina
1
,
Öhman Tiina
4
,
Róg Tomasz
3
,
Kankuri E.
1
,
Vilar M.
13
,
Varjosalo M.
4
,
Korpi E. R.
1
,
Permi Perttu
7, 14, 15
,
Mineev Konstantin S.
8, 9, 16
,
Saarma Mart
4
,
Vattulainen Ilpo
3
,
10
Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil
|
12
Biomedical Sciences, Hellenic University of Thessaloniki, Thessaloniki, Greece
|
13
Molecular Basis of Neurodegeneration Unit, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain
|
16
Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe University, Frankfurt am Main, Germany
|
Publication type: Journal Article
Publication date: 2023-06-05
Journal:
Nature Neuroscience
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 25
ISSN: 10976256, 15461726
General Neuroscience
Abstract
Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We recently reported that pharmacologically diverse antidepressants, including fluoxetine and ketamine, act by binding to TrkB, the receptor for BDNF. Here we show that lysergic acid diethylamide (LSD) and psilocin directly bind to TrkB with affinities 1,000-fold higher than those for other antidepressants, and that psychedelics and antidepressants bind to distinct but partially overlapping sites within the transmembrane domain of TrkB dimers. The effects of psychedelics on neurotrophic signaling, plasticity and antidepressant-like behavior in mice depend on TrkB binding and promotion of endogenous BDNF signaling but are independent of serotonin 2A receptor (5-HT2A) activation, whereas LSD-induced head twitching is dependent on 5-HT2A and independent of TrkB binding. Our data confirm TrkB as a common primary target for antidepressants and suggest that high-affinity TrkB positive allosteric modulators lacking 5-HT2A activity may retain the antidepressant potential of psychedelics without hallucinogenic effects.
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1
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5
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1 publication, 1.25%
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1 publication, 1.25%
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1 publication, 1.25%
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5
10
15
20
25
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Moliner R. et al. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB // Nature Neuroscience. 2023. Vol. 26. No. 6. pp. 1032-1041.
GOST all authors (up to 50)
Copy
Moliner R., Girych M., Brunello C., Kovaleva V., Biojone C., Enkavi G., Antenucci L., Kot E. F., Goncharuk S. A., Kaurinkoski K., Kuutti M., Fred S. M., Elsilä L. V., Sakson S., Cannarozzo C., Diniz C., Seiffert N., Rubiolo A., Haapaniemi H., Meshi E., Nagaeva E., Öhman T., Róg T., Kankuri E., Vilar M., Varjosalo M., Korpi E. R., Permi P., Mineev K., Saarma M., Vattulainen I., Casarotto P. C., Castrén E. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB // Nature Neuroscience. 2023. Vol. 26. No. 6. pp. 1032-1041.
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TY - JOUR
DO - 10.1038/s41593-023-01316-5
UR - https://doi.org/10.1038%2Fs41593-023-01316-5
TI - Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
T2 - Nature Neuroscience
AU - Moliner, Rafael
AU - Girych, Mykhailo
AU - Brunello, Cecilia
AU - Kovaleva, Vera
AU - Biojone, Caroline
AU - Enkavi, Giray
AU - Antenucci, Lina
AU - Kot, Erik F
AU - Goncharuk, Sergey A.
AU - Kaurinkoski, Katja
AU - Kuutti, Mirjami
AU - Fred, Senem Merve
AU - Elsilä, Lauri V
AU - Sakson, Sven
AU - Cannarozzo, Cecilia
AU - Diniz, Cassiano
AU - Seiffert, Nina
AU - Rubiolo, Anna
AU - Haapaniemi, Hele
AU - Meshi, Elsa
AU - Nagaeva, Elina
AU - Öhman, Tiina
AU - Róg, Tomasz
AU - Kankuri, E.
AU - Vilar, M.
AU - Varjosalo, M.
AU - Korpi, E. R.
AU - Permi, Perttu
AU - Mineev, Konstantin S.
AU - Saarma, Mart
AU - Vattulainen, Ilpo
AU - Casarotto, Plinio C.
AU - Castrén, E.
PY - 2023
DA - 2023/06/05 00:00:00
PB - Springer Nature
SP - 1032-1041
IS - 6
VL - 26
SN - 1097-6256
SN - 1546-1726
ER -
Cite this
BibTex
Copy
@article{2023_Moliner,
author = {Rafael Moliner and Mykhailo Girych and Cecilia Brunello and Vera Kovaleva and Caroline Biojone and Giray Enkavi and Lina Antenucci and Erik F Kot and Sergey A. Goncharuk and Katja Kaurinkoski and Mirjami Kuutti and Senem Merve Fred and Lauri V Elsilä and Sven Sakson and Cecilia Cannarozzo and Cassiano Diniz and Nina Seiffert and Anna Rubiolo and Hele Haapaniemi and Elsa Meshi and Elina Nagaeva and Tiina Öhman and Tomasz Róg and E. Kankuri and M. Vilar and M. Varjosalo and E. R. Korpi and Perttu Permi and Konstantin S. Mineev and Mart Saarma and Ilpo Vattulainen and Plinio C. Casarotto and E. Castrén},
title = {Psychedelics promote plasticity by directly binding to BDNF receptor TrkB},
journal = {Nature Neuroscience},
year = {2023},
volume = {26},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1038%2Fs41593-023-01316-5},
number = {6},
pages = {1032--1041},
doi = {10.1038/s41593-023-01316-5}
}
Cite this
MLA
Copy
Moliner, Rafael, et al. “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.” Nature Neuroscience, vol. 26, no. 6, Jun. 2023, pp. 1032-1041. https://doi.org/10.1038%2Fs41593-023-01316-5.