Open Access

Scientific Reports

, volume 7 , issue 1 , publication number 1394

Mitochondria-targeted antioxidants as highly effective antibiotics

Pavel A. Nazarov ¹

Ilya A. Osterman ^{2, 3}

Artem V Tokarchuk ¹

Marina V Karakozova ⁴

Galina A Korshunova ¹

Konstantin G Lyamzaev ¹

Maxim V. Skulachev ^{1, 5}

Elena A. Kotova ¹

Vladimir P. Skulachev ^{1, 5}

Yuri N Antonenko ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

Belozersky Institute of Physico-chemical Biology, Lomonosov Moscow State University, Moscow, Russia |

Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia |

Skolkovo Institute of Science and Technology, Skolkovo, Russia |

⁴

Vavilov Institute of General Genetics, Russian Academy of Science, Moscow, Russia |

⁵

Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia |

Publication type: Journal Article

Publication date: 2017-05-03

Springer Nature

Scientific Reports

scimago Q1

wos Q1

SJR: 0.874

CiteScore: 6.7

Impact factor: 3.9

ISSN: 20452322

DOI: 10.1038/s41598-017-00802-8

Copy DOI

PubMed ID: 28469140

Multidisciplinary

Abstract

Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobacterium sp. and Staphylococcus aureus and Gram-negative Photobacterium phosphoreum and Rhodobacter sphaeroides in submicromolar and micromolar concentrations. SkQ1 exhibited less antibiotic activity towards Escherichia coli due to the presence of the highly effective multidrug resistance pump AcrAB-TolC. E. coli mutants lacking AcrAB-TolC showed similar SkQ1 sensitivity, as B. subtilis. Lowering of the bacterial membrane potential by SkQ1 might be involved in the mechanism of its bactericidal action. No significant cytotoxic effect on mammalian cells was observed at bacteriotoxic concentrations of SkQ1. Therefore, SkQ1 may be effective in protection of the infected mammals by killing invading bacteria.

Found

3 citations

Konevega Andrey

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PhD in Physics and Mathematics

96 publications, 3 337 citations

h-index: 28

Peter the Great St. Petersburg Polytechnic University

National Research Centre "Kurchatov Institute"

Petersburg Nuclear Physics Institute of NRC «Kurchatov Institute»

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Lukianov Dmitrii

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Lomonosov Moscow State University

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Golubeva Julia

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Skvortsov Dmitry

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Volynkina Inna

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A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

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h-index: 22

North Caucasus Federal University

Kuban State University

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Biological activity

Heterocyclic compounds

Malononitrile

Selenoamides

Thioamides

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Orekhov Philipp

PhD in Biological/biomedical sciences, associate professor

46 publications, 740 citations, 75 reviews

h-index: 18

Shenzhen MSU-BIT University

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Computational Biology

Membrane proteins

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PhD in Chemistry

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h-index: 17

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Asymmetric metal complex catalysis

Chemistry of organic and organoelement compounds; chemistry of polymers; production of materials

Coordination chemistry of phosphorus

Organoelement chemistry

Organophosphorus chemistry

Synthesis of chiral phosphorus-containing ligands

1 citation

Belosludtseva Natalia

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Pathological physiology

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Belosludtsev Konstantin

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Aksenov Aleksandr

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North Caucasus Federal University

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Medicinal Chemistry

Organic Chemistry

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Luzina Olga

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N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

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Chemistry of natural compounds

Medicinal Chemistry

Organic Chemistry

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Ural Federal University

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GOST Copy

Nazarov P. A. et al. Mitochondria-targeted antioxidants as highly effective antibiotics // Scientific Reports. 2017. Vol. 7. No. 1. 1394

GOST all authors (up to 50) Copy

Nazarov P. A., Osterman I. A., Tokarchuk A. V., Karakozova M. V., Korshunova G. A., Lyamzaev K. G., Skulachev M. V., Kotova E. A., Skulachev V. P., Antonenko Y. N. Mitochondria-targeted antioxidants as highly effective antibiotics // Scientific Reports. 2017. Vol. 7. No. 1. 1394

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41598-017-00802-8

UR - https://www.nature.com/articles/s41598-017-00802-8

TI - Mitochondria-targeted antioxidants as highly effective antibiotics

T2 - Scientific Reports

AU - Nazarov, Pavel A.

AU - Osterman, Ilya A.

AU - Tokarchuk, Artem V

AU - Karakozova, Marina V

AU - Korshunova, Galina A

AU - Lyamzaev, Konstantin G

AU - Skulachev, Maxim V.

AU - Kotova, Elena A.

AU - Skulachev, Vladimir P.

AU - Antonenko, Yuri N

PY - 2017

DA - 2017/05/03

PB - Springer Nature

IS - 1

VL - 7

PMID - 28469140

SN - 2045-2322

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Nazarov,

author = {Pavel A. Nazarov and Ilya A. Osterman and Artem V Tokarchuk and Marina V Karakozova and Galina A Korshunova and Konstantin G Lyamzaev and Maxim V. Skulachev and Elena A. Kotova and Vladimir P. Skulachev and Yuri N Antonenko},

title = {Mitochondria-targeted antioxidants as highly effective antibiotics},

journal = {Scientific Reports},

year = {2017},

volume = {7},

publisher = {Springer Nature},

month = {may},

url = {https://www.nature.com/articles/s41598-017-00802-8},

number = {1},

pages = {1394},

doi = {10.1038/s41598-017-00802-8}

}

Publisher

Springer Nature

Journal

Scientific Reports

scimago Q1

wos Q1

SJR

0.874

CiteScore

6.7

Impact factor

3.9

ISSN

20452322 (Print, Electronic)

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