Open Access

Scientific Reports, volume 7, issue 1, publication number 1394

Mitochondria-targeted antioxidants as highly effective antibiotics

Nazarov Pavel A. ¹

Osterman Ilya A. ^{2, 3}

Tokarchuk Artem V ¹

Karakozova Marina V ⁴

Korshunova Galina A ¹

Lyamzaev Konstantin G ¹

Skulachev Maxim V. ^{1, 5}

Kotova Elena A. ¹

Skulachev Vladimir P. ^{1, 5}

Antonenko Yuri N ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

Belozersky Institute of Physico-chemical Biology, Lomonosov Moscow State University, Moscow, Russia |

Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia |

Skolkovo Institute of Science and Technology, Skolkovo, Russia |

⁴

Vavilov Institute of General Genetics, Russian Academy of Science, Moscow, Russia |

⁵

Institute of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia |

Publication type: Journal Article

Publication date: 2017-05-03

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/s41598-017-00802-8

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PubMed ID: 28469140

Multidisciplinary

Abstract

Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobacterium sp. and Staphylococcus aureus and Gram-negative Photobacterium phosphoreum and Rhodobacter sphaeroides in submicromolar and micromolar concentrations. SkQ1 exhibited less antibiotic activity towards Escherichia coli due to the presence of the highly effective multidrug resistance pump AcrAB-TolC. E. coli mutants lacking AcrAB-TolC showed similar SkQ1 sensitivity, as B. subtilis. Lowering of the bacterial membrane potential by SkQ1 might be involved in the mechanism of its bactericidal action. No significant cytotoxic effect on mammalian cells was observed at bacteriotoxic concentrations of SkQ1. Therefore, SkQ1 may be effective in protection of the infected mammals by killing invading bacteria.

By date By citations

Citations by journals

	1 2 3 4 5 6 7 8
Antibiotics	Antibiotics, 8, 16.33% Antibiotics 8 publications, 16.33%
Biochemistry (Moscow)	Biochemistry (Moscow), 3, 6.12% Biochemistry (Moscow) 3 publications, 6.12%
Russian Journal of General Chemistry	Russian Journal of General Chemistry, 2, 4.08% Russian Journal of General Chemistry 2 publications, 4.08%
Биохимия	Биохимия, 2, 4.08% Биохимия 2 publications, 4.08%
Pharmaceutics	Pharmaceutics, 2, 4.08% Pharmaceutics 2 publications, 4.08%
Frontiers in Microbiology	Frontiers in Microbiology, 2, 4.08% Frontiers in Microbiology 2 publications, 4.08%
Free Radical Biology and Medicine	Free Radical Biology and Medicine, 2, 4.08% Free Radical Biology and Medicine 2 publications, 4.08%
ACS Omega	ACS Omega, 1, 2.04% ACS Omega 1 publication, 2.04%
Bioorganic and Medicinal Chemistry Letters	Bioorganic and Medicinal Chemistry Letters, 1, 2.04% Bioorganic and Medicinal Chemistry Letters 1 publication, 2.04%
Biomolecules	Biomolecules, 1, 2.04% Biomolecules 1 publication, 2.04%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.04% International Journal of Molecular Sciences 1 publication, 2.04%
Pathogens	Pathogens, 1, 2.04% Pathogens 1 publication, 2.04%
Scientific Reports	Scientific Reports, 1, 2.04% Scientific Reports 1 publication, 2.04%
Chemistry of Heterocyclic Compounds	Chemistry of Heterocyclic Compounds, 1, 2.04% Chemistry of Heterocyclic Compounds 1 publication, 2.04%
Nature	Nature, 1, 2.04% Nature 1 publication, 2.04%
Journal of Bioscience and Bioengineering	Journal of Bioscience and Bioengineering, 1, 2.04% Journal of Bioscience and Bioengineering 1 publication, 2.04%
Bioorganic Chemistry	Bioorganic Chemistry, 1, 2.04% Bioorganic Chemistry 1 publication, 2.04%
Current Research in Pharmacology and Drug Discovery	Current Research in Pharmacology and Drug Discovery, 1, 2.04% Current Research in Pharmacology and Drug Discovery 1 publication, 2.04%
Journal of Advanced Research	Journal of Advanced Research, 1, 2.04% Journal of Advanced Research 1 publication, 2.04%
Biochimica et Biophysica Acta - Bioenergetics	Biochimica et Biophysica Acta - Bioenergetics, 1, 2.04% Biochimica et Biophysica Acta - Bioenergetics 1 publication, 2.04%
Microbial Pathogenesis	Microbial Pathogenesis, 1, 2.04% Microbial Pathogenesis 1 publication, 2.04%
Pharmaceuticals	Pharmaceuticals, 1, 2.04% Pharmaceuticals 1 publication, 2.04%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 1, 2.04% European Journal of Medicinal Chemistry 1 publication, 2.04%
Chemistry - A European Journal	Chemistry - A European Journal, 1, 2.04% Chemistry - A European Journal 1 publication, 2.04%
Bioconjugate Chemistry	Bioconjugate Chemistry, 1, 2.04% Bioconjugate Chemistry 1 publication, 2.04%
Journal of Physical Chemistry B	Journal of Physical Chemistry B, 1, 2.04% Journal of Physical Chemistry B 1 publication, 2.04%
Metabolites	Metabolites, 1, 2.04% Metabolites 1 publication, 2.04%
ACS Infectious Diseases	ACS Infectious Diseases, 1, 2.04% ACS Infectious Diseases 1 publication, 2.04%
Biofouling	Biofouling, 1, 2.04% Biofouling 1 publication, 2.04%
	1 2 3 4 5 6 7 8

Citations by publishers

	2 4 6 8 10 12 14 16
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 15, 30.61% Multidisciplinary Digital Publishing Institute (MDPI) 15 publications, 30.61%
Elsevier	Elsevier, 9, 18.37% Elsevier 9 publications, 18.37%
Pleiades Publishing	Pleiades Publishing, 8, 16.33% Pleiades Publishing 8 publications, 16.33%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 8.16% American Chemical Society (ACS) 4 publications, 8.16%
Springer Nature	Springer Nature, 3, 6.12% Springer Nature 3 publications, 6.12%
Frontiers Media S.A.	Frontiers Media S.A., 2, 4.08% Frontiers Media S.A. 2 publications, 4.08%
Cairo University	Cairo University, 1, 2.04% Cairo University 1 publication, 2.04%
Wiley	Wiley, 1, 2.04% Wiley 1 publication, 2.04%
Taylor & Francis	Taylor & Francis, 1, 2.04% Taylor & Francis 1 publication, 2.04%
Moscow University Press	Moscow University Press, 1, 2.04% Moscow University Press 1 publication, 2.04%
Bentham Science	Bentham Science, 1, 2.04% Bentham Science 1 publication, 2.04%
	2 4 6 8 10 12 14 16

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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Nazarov P. A. et al. Mitochondria-targeted antioxidants as highly effective antibiotics // Scientific Reports. 2017. Vol. 7. No. 1. 1394

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Nazarov P. A., Osterman I. A., Tokarchuk A. V., Karakozova M. V., Korshunova G. A., Lyamzaev K. G., Skulachev M. V., Kotova E. A., Skulachev V. P., Antonenko Y. N. Mitochondria-targeted antioxidants as highly effective antibiotics // Scientific Reports. 2017. Vol. 7. No. 1. 1394

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41598-017-00802-8

UR - https://doi.org/10.1038%2Fs41598-017-00802-8

TI - Mitochondria-targeted antioxidants as highly effective antibiotics

T2 - Scientific Reports

AU - Nazarov, Pavel A.

AU - Osterman, Ilya A.

AU - Tokarchuk, Artem V

AU - Karakozova, Marina V

AU - Korshunova, Galina A

AU - Lyamzaev, Konstantin G

AU - Skulachev, Maxim V.

AU - Kotova, Elena A.

AU - Skulachev, Vladimir P.

AU - Antonenko, Yuri N

PY - 2017

DA - 2017/05/03 00:00:00

PB - Springer Nature

IS - 1

VL - 7

PMID - 28469140

SN - 2045-2322

ER -

BibTex

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BibTex Copy

@article{2017_Nazarov,

author = {Pavel A. Nazarov and Ilya A. Osterman and Artem V Tokarchuk and Marina V Karakozova and Galina A Korshunova and Konstantin G Lyamzaev and Maxim V. Skulachev and Elena A. Kotova and Vladimir P. Skulachev and Yuri N Antonenko},

title = {Mitochondria-targeted antioxidants as highly effective antibiotics},

journal = {Scientific Reports},

year = {2017},

volume = {7},

publisher = {Springer Nature},

month = {may},

url = {https://doi.org/10.1038%2Fs41598-017-00802-8},

number = {1},

doi = {10.1038/s41598-017-00802-8}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

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