Open Access
Mitochondria-targeted antioxidants as highly effective antibiotics
Pavel A. Nazarov
1
,
Ilya A. Osterman
2, 3
,
Artem V Tokarchuk
1
,
Marina V Karakozova
4
,
Galina A Korshunova
1
,
Maxim V. Skulachev
1, 5
,
Elena A. Kotova
1
,
Vladimir P. Skulachev
1, 5
,
Yuri N Antonenko
1
1
Тип публикации: Journal Article
Дата публикации: 2017-05-03
scimago Q1
wos Q1
БС1
SJR: 0.874
CiteScore: 6.7
Impact factor: 3.9
ISSN: 20452322
PubMed ID:
28469140
Multidisciplinary
Краткое описание
Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobacterium sp. and Staphylococcus aureus and Gram-negative Photobacterium phosphoreum and Rhodobacter sphaeroides in submicromolar and micromolar concentrations. SkQ1 exhibited less antibiotic activity towards Escherichia coli due to the presence of the highly effective multidrug resistance pump AcrAB-TolC. E. coli mutants lacking AcrAB-TolC showed similar SkQ1 sensitivity, as B. subtilis. Lowering of the bacterial membrane potential by SkQ1 might be involved in the mechanism of its bactericidal action. No significant cytotoxic effect on mammalian cells was observed at bacteriotoxic concentrations of SkQ1. Therefore, SkQ1 may be effective in protection of the infected mammals by killing invading bacteria.
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ГОСТ
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Nazarov P. A. et al. Mitochondria-targeted antioxidants as highly effective antibiotics // Scientific Reports. 2017. Vol. 7. No. 1. 1394
ГОСТ со всеми авторами (до 50)
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Nazarov P. A., Osterman I. A., Tokarchuk A. V., Karakozova M. V., Korshunova G. A., Lyamzaev K. G., Skulachev M. V., Kotova E. A., Skulachev V. P., Antonenko Y. N. Mitochondria-targeted antioxidants as highly effective antibiotics // Scientific Reports. 2017. Vol. 7. No. 1. 1394
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TY - JOUR
DO - 10.1038/s41598-017-00802-8
UR - https://www.nature.com/articles/s41598-017-00802-8
TI - Mitochondria-targeted antioxidants as highly effective antibiotics
T2 - Scientific Reports
AU - Nazarov, Pavel A.
AU - Osterman, Ilya A.
AU - Tokarchuk, Artem V
AU - Karakozova, Marina V
AU - Korshunova, Galina A
AU - Lyamzaev, Konstantin G
AU - Skulachev, Maxim V.
AU - Kotova, Elena A.
AU - Skulachev, Vladimir P.
AU - Antonenko, Yuri N
PY - 2017
DA - 2017/05/03
PB - Springer Nature
IS - 1
VL - 7
PMID - 28469140
SN - 2045-2322
ER -
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BibTex (до 50 авторов)
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@article{2017_Nazarov,
author = {Pavel A. Nazarov and Ilya A. Osterman and Artem V Tokarchuk and Marina V Karakozova and Galina A Korshunova and Konstantin G Lyamzaev and Maxim V. Skulachev and Elena A. Kotova and Vladimir P. Skulachev and Yuri N Antonenko},
title = {Mitochondria-targeted antioxidants as highly effective antibiotics},
journal = {Scientific Reports},
year = {2017},
volume = {7},
publisher = {Springer Nature},
month = {may},
url = {https://www.nature.com/articles/s41598-017-00802-8},
number = {1},
pages = {1394},
doi = {10.1038/s41598-017-00802-8}
}