Open Access
Scientific Reports, volume 7, issue 1, publication number 7887
Virtual cardiac monolayers for electrical wave propagation
Publication type: Journal Article
Publication date: 2017-08-11
PubMed ID:
28801548
Multidisciplinary
Abstract
The complex structure of cardiac tissue is considered to be one of the main determinants of an arrhythmogenic substrate. This study is aimed at developing the first mathematical model to describe the formation of cardiac tissue, using a joint in silico–in vitro approach. First, we performed experiments under various conditions to carefully characterise the morphology of cardiac tissue in a culture of neonatal rat ventricular cells. We considered two cell types, namely, cardiomyocytes and fibroblasts. Next, we proposed a mathematical model, based on the Glazier-Graner-Hogeweg model, which is widely used in tissue growth studies. The resultant tissue morphology was coupled to the detailed electrophysiological Korhonen-Majumder model for neonatal rat ventricular cardiomyocytes, in order to study wave propagation. The simulated waves had the same anisotropy ratio and wavefront complexity as those in the experiment. Thus, we conclude that our approach allows us to reproduce the morphological and physiological properties of cardiac tissue.
Citations by journals
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Scientific Reports
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2 publications, 16.67%
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PLoS Computational Biology
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1 publication, 8.33%
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Physical Review Research
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1 publication, 8.33%
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1 publication, 8.33%
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1 publication, 8.33%
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1 publication, 8.33%
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Communications in Nonlinear Science and Numerical Simulation
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Communications in Nonlinear Science and Numerical Simulation
1 publication, 8.33%
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Journal of Microscopy
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1 publication, 8.33%
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Journal of Applied Physics
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1 publication, 8.33%
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1 publication, 8.33%
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Citations by publishers
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3
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Springer Nature
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3 publications, 25%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 16.67%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
1 publication, 8.33%
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American Physical Society (APS)
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American Physical Society (APS)
1 publication, 8.33%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 8.33%
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Elsevier
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Elsevier
1 publication, 8.33%
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Wiley
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Wiley
1 publication, 8.33%
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American Institute of Physics (AIP)
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American Institute of Physics (AIP)
1 publication, 8.33%
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3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kudryashova N. et al. Virtual cardiac monolayers for electrical wave propagation // Scientific Reports. 2017. Vol. 7. No. 1. 7887
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Kudryashova N., Tsvelaya V., Agladze K. I., Panfilov A. Virtual cardiac monolayers for electrical wave propagation // Scientific Reports. 2017. Vol. 7. No. 1. 7887
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TY - JOUR
DO - 10.1038/s41598-017-07653-3
UR - https://doi.org/10.1038%2Fs41598-017-07653-3
TI - Virtual cardiac monolayers for electrical wave propagation
T2 - Scientific Reports
AU - Tsvelaya, Valeriya
AU - Agladze, K. I.
AU - Panfilov, Alexander
AU - Kudryashova, Nina
PY - 2017
DA - 2017/08/11 00:00:00
PB - Springer Nature
IS - 1
VL - 7
PMID - 28801548
SN - 2045-2322
ER -
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@article{2017_Kudryashova,
author = {Valeriya Tsvelaya and K. I. Agladze and Alexander Panfilov and Nina Kudryashova},
title = {Virtual cardiac monolayers for electrical wave propagation},
journal = {Scientific Reports},
year = {2017},
volume = {7},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1038%2Fs41598-017-07653-3},
number = {1},
doi = {10.1038/s41598-017-07653-3}
}
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