Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics
High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T2 relaxivity for magnetic resonance imaging as compared to other types of Fe3O4-Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe3O4-Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo. The delivery to tumors and payload release are demonstrated in real time by intravital microscopy. Replacing the dyes by cell-specific molecules and drugs makes the Fe3O4-Au hybrids a unique all-in-one platform for theranostics.
Citations by journals
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Nanomaterials
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Nanomaterials
4 publications, 5.33%
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ACS applied materials & interfaces
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ACS applied materials & interfaces
4 publications, 5.33%
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Pharmaceutics
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Pharmaceutics
4 publications, 5.33%
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Nanoscale
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Nanoscale
3 publications, 4%
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Beilstein Journal of Nanotechnology
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Beilstein Journal of Nanotechnology
2 publications, 2.67%
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Magnetochemistry
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Magnetochemistry
2 publications, 2.67%
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Cancers
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Cancers
2 publications, 2.67%
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Materials
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Materials
2 publications, 2.67%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 2.67%
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Scientific Reports
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Scientific Reports
2 publications, 2.67%
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Journal of Materials Chemistry B
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Journal of Materials Chemistry B
1 publication, 1.33%
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Cells
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Cells
1 publication, 1.33%
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Journal of Magnetism and Magnetic Materials
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Journal of Magnetism and Magnetic Materials
1 publication, 1.33%
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Nanomedicine
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Nanomedicine
1 publication, 1.33%
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Nanobiomedicine
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Nanobiomedicine
1 publication, 1.33%
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Molecules
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Molecules
1 publication, 1.33%
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Frontiers in Chemistry
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Frontiers in Chemistry
1 publication, 1.33%
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Metal Science and Heat Treatment
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Metal Science and Heat Treatment
1 publication, 1.33%
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Journal of Hazardous Materials
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Journal of Hazardous Materials
1 publication, 1.33%
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Journal of Cluster Science
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Journal of Cluster Science
1 publication, 1.33%
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Nano Research
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Nano Research
1 publication, 1.33%
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Topics in Current Chemistry
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Topics in Current Chemistry
1 publication, 1.33%
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Communications Biology
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Communications Biology
1 publication, 1.33%
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Advanced Drug Delivery Reviews
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Advanced Drug Delivery Reviews
1 publication, 1.33%
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Bioorganic Chemistry
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Bioorganic Chemistry
1 publication, 1.33%
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Trends in Biotechnology
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Trends in Biotechnology
1 publication, 1.33%
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EBioMedicine
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EBioMedicine
1 publication, 1.33%
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Materials Chemistry and Physics
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Materials Chemistry and Physics
1 publication, 1.33%
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Chinese Chemical Letters
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Chinese Chemical Letters
1 publication, 1.33%
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
20 publications, 26.67%
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Springer Nature
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Springer Nature
9 publications, 12%
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Elsevier
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Elsevier
8 publications, 10.67%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
6 publications, 8%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
6 publications, 8%
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Pleiades Publishing
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Pleiades Publishing
4 publications, 5.33%
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Beilstein-Institut
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Beilstein-Institut
2 publications, 2.67%
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Wiley
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Wiley
2 publications, 2.67%
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Future Medicine
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Future Medicine
1 publication, 1.33%
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SAGE
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SAGE
1 publication, 1.33%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 1.33%
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Dove Medical Press
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Dove Medical Press
1 publication, 1.33%
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Bentham Science
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Bentham Science
1 publication, 1.33%
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Associacao Brasileira de Engenharia Sanitaria e Ambiental
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Associacao Brasileira de Engenharia Sanitaria e Ambiental, 1, 1.33%
Associacao Brasileira de Engenharia Sanitaria e Ambiental
1 publication, 1.33%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.