Open Access
Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics
Тип публикации: Journal Article
Дата публикации: 2018-07-26
scimago Q1
wos Q1
БС1
SJR: 0.874
CiteScore: 6.7
Impact factor: 3.9
ISSN: 20452322
PubMed ID:
30050080
Multidisciplinary
Краткое описание
High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T2 relaxivity for magnetic resonance imaging as compared to other types of Fe3O4-Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe3O4-Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo. The delivery to tumors and payload release are demonstrated in real time by intravital microscopy. Replacing the dyes by cell-specific molecules and drugs makes the Fe3O4-Au hybrids a unique all-in-one platform for theranostics.
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BibTex
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ГОСТ
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Efremova M. et al. Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics // Scientific Reports. 2018. Vol. 8. No. 1. 11295
ГОСТ со всеми авторами (до 50)
Скопировать
Efremova M., Naumenko V. A., Spasova M., Garanina A. S., Abakumov M. A., Blokhina A. D., Melnikov P. A., Prelovskaya A. O., Heidelmann M., Li Z., Ma Z., Shchetinin I. V., Golovin Y. I., Kireev I., Savchenko A. G., Chekhonin V. P., Klyachko N. L., Farle M., Majouga A. G., Wiedwald U. Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics // Scientific Reports. 2018. Vol. 8. No. 1. 11295
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RIS
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TY - JOUR
DO - 10.1038/s41598-018-29618-w
UR - https://www.nature.com/articles/s41598-018-29618-w
TI - Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics
T2 - Scientific Reports
AU - Efremova, Maria
AU - Naumenko, Victor A
AU - Spasova, Marina
AU - Garanina, A. S.
AU - Abakumov, Maxim A.
AU - Blokhina, Anastasia D
AU - Melnikov, Pavel A
AU - Prelovskaya, Alexandra O
AU - Heidelmann, Markus
AU - Li, Zi-An
AU - Ma, Zheng
AU - Shchetinin, Igor V.
AU - Golovin, Yuri I
AU - Kireev, I.
AU - Savchenko, Alexander G.
AU - Chekhonin, Vladimir P
AU - Klyachko, Natalia L
AU - Farle, Michael
AU - Majouga, Alexander G.
AU - Wiedwald, U.
PY - 2018
DA - 2018/07/26
PB - Springer Nature
IS - 1
VL - 8
PMID - 30050080
SN - 2045-2322
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2018_Efremova,
author = {Maria Efremova and Victor A Naumenko and Marina Spasova and A. S. Garanina and Maxim A. Abakumov and Anastasia D Blokhina and Pavel A Melnikov and Alexandra O Prelovskaya and Markus Heidelmann and Zi-An Li and Zheng Ma and Igor V. Shchetinin and Yuri I Golovin and I. Kireev and Alexander G. Savchenko and Vladimir P Chekhonin and Natalia L Klyachko and Michael Farle and Alexander G. Majouga and U. Wiedwald},
title = {Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics},
journal = {Scientific Reports},
year = {2018},
volume = {8},
publisher = {Springer Nature},
month = {jul},
url = {https://www.nature.com/articles/s41598-018-29618-w},
number = {1},
pages = {11295},
doi = {10.1038/s41598-018-29618-w}
}