Open Access
Open access
Scientific Reports, volume 8, issue 1, publication number 11295

Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics

Efremova Maria 1, 2
Naumenko Victor A 1
Spasova Marina 3
Garanina A. S. 1, 2
Blokhina Anastasia D 2
Melnikov Pavel A 5
Prelovskaya Alexandra O 1
Heidelmann Markus 6
Li Zi-An 3
Ma Zheng 3
Golovin Yuri I 2, 7
Kireev I. 8
Savchenko Alexander G. 1
Chekhonin Vladimir P 4, 5
Klyachko Natalia L 1, 2
Farle Michael 3
Majouga Alexander G. 1, 2, 9
Publication typeJournal Article
Publication date2018-07-26
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor4.6
ISSN20452322
Multidisciplinary
Abstract

High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T2 relaxivity for magnetic resonance imaging as compared to other types of Fe3O4-Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe3O4-Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo. The delivery to tumors and payload release are demonstrated in real time by intravital microscopy. Replacing the dyes by cell-specific molecules and drugs makes the Fe3O4-Au hybrids a unique all-in-one platform for theranostics.

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GOST Copy
Efremova M. et al. Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics // Scientific Reports. 2018. Vol. 8. No. 1. 11295
GOST all authors (up to 50) Copy
Efremova M., Naumenko V. A., Spasova M., Garanina A. S., Abakumov M. A., Blokhina A. D., Melnikov P. A., Prelovskaya A. O., Heidelmann M., Li Z., Ma Z., Shchetinin I. V., Golovin Y. I., Kireev I., Savchenko A. G., Chekhonin V. P., Klyachko N. L., Farle M., Majouga A. G., Wiedwald U. Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics // Scientific Reports. 2018. Vol. 8. No. 1. 11295
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/s41598-018-29618-w
UR - https://doi.org/10.1038%2Fs41598-018-29618-w
TI - Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics
T2 - Scientific Reports
AU - Efremova, Maria
AU - Naumenko, Victor A
AU - Spasova, Marina
AU - Garanina, A. S.
AU - Abakumov, Maxim A.
AU - Blokhina, Anastasia D
AU - Prelovskaya, Alexandra O
AU - Heidelmann, Markus
AU - Kireev, I.
AU - Klyachko, Natalia L
AU - Wiedwald, U.
AU - Melnikov, Pavel A
AU - Li, Zi-An
AU - Ma, Zheng
AU - Golovin, Yuri I
AU - Savchenko, Alexander G.
AU - Chekhonin, Vladimir P
AU - Shchetinin, Igor V.
AU - Majouga, Alexander G.
AU - Farle, Michael
PY - 2018
DA - 2018/07/26 00:00:00
PB - Springer Nature
IS - 1
VL - 8
PMID - 30050080
SN - 2045-2322
ER -
BibTex
Cite this
BibTex Copy
@article{2018_Efremova
author = {Maria Efremova and Victor A Naumenko and Marina Spasova and A. S. Garanina and Maxim A. Abakumov and Anastasia D Blokhina and Alexandra O Prelovskaya and Markus Heidelmann and I. Kireev and Natalia L Klyachko and U. Wiedwald and Pavel A Melnikov and Zi-An Li and Zheng Ma and Yuri I Golovin and Alexander G. Savchenko and Vladimir P Chekhonin and Igor V. Shchetinin and Alexander G. Majouga and Michael Farle},
title = {Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics},
journal = {Scientific Reports},
year = {2018},
volume = {8},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1038%2Fs41598-018-29618-w},
number = {1},
doi = {10.1038/s41598-018-29618-w}
}
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