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Scientific Reports, том 9, издание 1, номер публикации: 1701

Integrator is a key component of human telomerase RNA biogenesis

Rubtsova M. P. 1, 2
Moshareva M. A. 2
Meerson M. B. 2
Zatsepin T. S. 1, 2
Naraykina Y. V. 1, 2
Beletsky A. V. 3
Ravin N. V. 3
Dontsova O. A. 1, 2, 4
Тип документаJournal Article
Дата публикации2019-02-08
ИздательSpringer Nature
Название журналаScientific Reports
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ2
Импакт-фактор 20215.00
Краткое описание
Telomeres are special DNA-protein structures that are located at the ends of linear eukaryotic chromosomes. The telomere length determines the proliferation potential of cells. Telomerase is a key component of the telomere length maintenance system. While telomerase is inactive in the majority of somatic cells, its activity determines the clonogenic potential of stem cells as a resource for tissue and organism regeneration. Reactivation of telomerase occurs during the process of immortalization in the majority of cancer cells. Telomerase is a ribonucleoprotein that contains telomerase reverse transcriptase and telomerase RNA components. The RNA processing mechanism of telomerase involves exosome trimming or degradation of the primary precursor. Recent data provide evidence that the competition between the processing and decay of telomerase RNA may regulate the amount of RNA at the physiological level. We show that termination of human telomerase RNA transcription is dependent on its promoter, which engages with the multisubunit complex Integrator to interact with RNA polymerase II and terminate transcription of the human telomerase RNA gene followed by further processing.
Пристатейные ссылки: 37
Цитируется в публикациях: 28
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1. Rubtsova M.P. и др. Integrator is a key component of human telomerase RNA biogenesis // Scientific Reports. 2019. Т. 9. № 1.


DO - 10.1038/s41598-018-38297-6

UR -

TI - Integrator is a key component of human telomerase RNA biogenesis

T2 - Scientific Reports

AU - Rubtsova, M. P.

AU - Vasilkova, D. P.

AU - Moshareva, M. A.

AU - Malyavko, A. N.

AU - Meerson, M. B.

AU - Zatsepin, T. S.

AU - Naraykina, Y. V.

AU - Beletsky, A. V.

AU - Ravin, N. V.

AU - Dontsova, O. A.

PY - 2019

DA - 2019/02/08

PB - Springer Science and Business Media LLC

IS - 1

VL - 9

SN - 2045-2322

ER -

BibTex |


doi = {10.1038/s41598-018-38297-6},

url = {},

year = 2019,

month = {feb},

publisher = {Springer Science and Business Media {LLC}},

volume = {9},

number = {1},

author = {M. P. Rubtsova and D. P. Vasilkova and M. A. Moshareva and A. N. Malyavko and M. B. Meerson and T. S. Zatsepin and Y. V. Naraykina and A. V. Beletsky and N. V. Ravin and O. A. Dontsova},

title = {Integrator is a key component of human telomerase {RNA} biogenesis}


Rubtsova, M. P. et al. “Integrator Is a Key Component of Human Telomerase RNA Biogenesis.” Scientific Reports 9.1 (2019): n. pag. Crossref. Web.