Open Access

Scientific Reports, volume 9, issue 1, publication number 1701

Integrator is a key component of human telomerase RNA biogenesis

Rubtsova M. P. ^{1, 2}

Vasilkova D P ²

Moshareva M A ²

Malyavko A N ²

Meerson M B ²

Zatsepin T S ^{1, 2}

Naraykina Y V ^{1, 2}

Beletsky A V ³

Ravin N. V. ³

Dontsova O. A. ^{1, 2, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, Russia |

Lomonosov Moscow State University, Department of Chemistry, Faculty of Bioengineering and Bioinformatics and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russia |

Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia |

⁴

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia |

Publication type: Journal Article

Publication date: 2019-02-08

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/s41598-018-38297-6

Copy DOI

PubMed ID: 30737432

Multidisciplinary

Abstract

Telomeres are special DNA-protein structures that are located at the ends of linear eukaryotic chromosomes. The telomere length determines the proliferation potential of cells. Telomerase is a key component of the telomere length maintenance system. While telomerase is inactive in the majority of somatic cells, its activity determines the clonogenic potential of stem cells as a resource for tissue and organism regeneration. Reactivation of telomerase occurs during the process of immortalization in the majority of cancer cells. Telomerase is a ribonucleoprotein that contains telomerase reverse transcriptase and telomerase RNA components. The RNA processing mechanism of telomerase involves exosome trimming or degradation of the primary precursor. Recent data provide evidence that the competition between the processing and decay of telomerase RNA may regulate the amount of RNA at the physiological level. We show that termination of human telomerase RNA transcription is dependent on its promoter, which engages with the multisubunit complex Integrator to interact with RNA polymerase II and terminate transcription of the human telomerase RNA gene followed by further processing.

By date By citations

Citations by journals

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Nature Communications	Nature Communications, 3, 8.33% Nature Communications 3 publications, 8.33%
Molecular Cell	Molecular Cell, 3, 8.33% Molecular Cell 3 publications, 8.33%
Biomedicines	Biomedicines, 2, 5.56% Biomedicines 2 publications, 5.56%
Nature Reviews Molecular Cell Biology	Nature Reviews Molecular Cell Biology, 2, 5.56% Nature Reviews Molecular Cell Biology 2 publications, 5.56%
Science	Science, 2, 5.56% Science 2 publications, 5.56%
Biomolecules	Biomolecules, 1, 2.78% Biomolecules 1 publication, 2.78%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 1, 2.78% Frontiers in Cell and Developmental Biology 1 publication, 2.78%
Biochemistry (Moscow)	Biochemistry (Moscow), 1, 2.78% Biochemistry (Moscow) 1 publication, 2.78%
Биохимия	Биохимия, 1, 2.78% Биохимия 1 publication, 2.78%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.78% International Journal of Molecular Sciences 1 publication, 2.78%
Frontiers in Neuroscience	Frontiers in Neuroscience, 1, 2.78% Frontiers in Neuroscience 1 publication, 2.78%
Science China Life Sciences	Science China Life Sciences, 1, 2.78% Science China Life Sciences 1 publication, 2.78%
Current Opinion in Structural Biology	Current Opinion in Structural Biology, 1, 2.78% Current Opinion in Structural Biology 1 publication, 2.78%
American Journal of Human Genetics	American Journal of Human Genetics, 1, 2.78% American Journal of Human Genetics 1 publication, 2.78%
Trends in Biochemical Sciences	Trends in Biochemical Sciences, 1, 2.78% Trends in Biochemical Sciences 1 publication, 2.78%
Cell	Cell, 1, 2.78% Cell 1 publication, 2.78%
Current Opinion in Cell Biology	Current Opinion in Cell Biology, 1, 2.78% Current Opinion in Cell Biology 1 publication, 2.78%
RNA Biology	RNA Biology, 1, 2.78% RNA Biology 1 publication, 2.78%
Transcription	Transcription, 1, 2.78% Transcription 1 publication, 2.78%
Genes and Development	Genes and Development, 1, 2.78% Genes and Development 1 publication, 2.78%
Cold Spring Harbor Symposia on Quantitative Biology	Cold Spring Harbor Symposia on Quantitative Biology, 1, 2.78% Cold Spring Harbor Symposia on Quantitative Biology 1 publication, 2.78%
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Citations by publishers

	1 2 3 4 5 6 7 8
Elsevier	Elsevier, 8, 22.22% Elsevier 8 publications, 22.22%
Springer Nature	Springer Nature, 6, 16.67% Springer Nature 6 publications, 16.67%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 4, 11.11% Multidisciplinary Digital Publishing Institute (MDPI) 4 publications, 11.11%
Frontiers Media S.A.	Frontiers Media S.A., 2, 5.56% Frontiers Media S.A. 2 publications, 5.56%
Pleiades Publishing	Pleiades Publishing, 2, 5.56% Pleiades Publishing 2 publications, 5.56%
Taylor & Francis	Taylor & Francis, 2, 5.56% Taylor & Francis 2 publications, 5.56%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 2, 5.56% American Association for the Advancement of Science (AAAS) 2 publications, 5.56%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 2, 5.56% Cold Spring Harbor Laboratory 2 publications, 5.56%
	1 2 3 4 5 6 7 8

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Rubtsova M. P. et al. Integrator is a key component of human telomerase RNA biogenesis // Scientific Reports. 2019. Vol. 9. No. 1. 1701

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Rubtsova M. P., Vasilkova D. P., Moshareva M. A., Malyavko A. N., Meerson M. B., Zatsepin T. S., Naraykina Y. V., Beletsky A. V., Ravin N. V., Dontsova O. A. Integrator is a key component of human telomerase RNA biogenesis // Scientific Reports. 2019. Vol. 9. No. 1. 1701

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RIS Copy

TY - JOUR

DO - 10.1038/s41598-018-38297-6

UR - https://doi.org/10.1038%2Fs41598-018-38297-6

TI - Integrator is a key component of human telomerase RNA biogenesis

T2 - Scientific Reports

AU - Rubtsova, M. P.

AU - Vasilkova, D P

AU - Moshareva, M A

AU - Malyavko, A N

AU - Meerson, M B

AU - Zatsepin, T S

AU - Naraykina, Y V

AU - Beletsky, A V

AU - Ravin, N. V.

AU - Dontsova, O. A.

PY - 2019

DA - 2019/02/08 00:00:00

PB - Springer Nature

IS - 1

VL - 9

PMID - 30737432

SN - 2045-2322

ER -

BibTex

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@article{2019_Rubtsova,

author = {M. P. Rubtsova and D P Vasilkova and M A Moshareva and A N Malyavko and M B Meerson and T S Zatsepin and Y V Naraykina and A V Beletsky and N. V. Ravin and O. A. Dontsova},

title = {Integrator is a key component of human telomerase RNA biogenesis},

journal = {Scientific Reports},

year = {2019},

volume = {9},

publisher = {Springer Nature},

month = {feb},

url = {https://doi.org/10.1038%2Fs41598-018-38297-6},

number = {1},

doi = {10.1038/s41598-018-38297-6}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

Labs

Laboratory of Nucleoprotein Chemistry, Department of Chemistry of Natural Compounds, Faculty of Chemistry

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