Open Access
Assessment of variability in the plasma 7k SomaScan proteomics assay
Тип публикации: Journal Article
Дата публикации: 2022-10-13
scimago Q1
wos Q1
БС1
SJR: 0.874
CiteScore: 6.7
Impact factor: 3.9
ISSN: 20452322
PubMed ID:
36229504
Multidisciplinary
Краткое описание
SomaScan is a high-throughput, aptamer-based proteomics assay designed for the simultaneous measurement of thousands of proteins with a broad range of endogenous concentrations. In its most current version, the 7k SomaScan assay v4.1 is capable of measuring 7288 human proteins. In this work, we present an extensive technical assessment of this platform based on a study of 2050 samples across 22 plates. Included in the study design were inter-plate technical duplicates from 102 human subjects, which allowed us to characterize different normalization procedures, evaluate assay variability by multiple analytical approaches, present signal-over-background metrics, and discuss potential specificity issues. By providing detailed performance assessments on this wide range of technical aspects, we aim for this work to serve as a valuable resource for the growing community of SomaScan users.
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ГОСТ
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Candia J. et al. Assessment of variability in the plasma 7k SomaScan proteomics assay // Scientific Reports. 2022. Vol. 12. No. 1. 17147
ГОСТ со всеми авторами (до 50)
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Candia J., Daya G. N., Tanaka T., Ferrucci L., Walker K. A. Assessment of variability in the plasma 7k SomaScan proteomics assay // Scientific Reports. 2022. Vol. 12. No. 1. 17147
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TY - JOUR
DO - 10.1038/s41598-022-22116-0
UR - https://doi.org/10.1038/s41598-022-22116-0
TI - Assessment of variability in the plasma 7k SomaScan proteomics assay
T2 - Scientific Reports
AU - Candia, Julián
AU - Daya, Gulzar N
AU - Tanaka, Toshiko
AU - Ferrucci, Luigi
AU - Walker, Keenan A.
PY - 2022
DA - 2022/10/13
PB - Springer Nature
IS - 1
VL - 12
PMID - 36229504
SN - 2045-2322
ER -
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BibTex (до 50 авторов)
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@article{2022_Candia,
author = {Julián Candia and Gulzar N Daya and Toshiko Tanaka and Luigi Ferrucci and Keenan A. Walker},
title = {Assessment of variability in the plasma 7k SomaScan proteomics assay},
journal = {Scientific Reports},
year = {2022},
volume = {12},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1038/s41598-022-22116-0},
number = {1},
pages = {17147},
doi = {10.1038/s41598-022-22116-0}
}