Open Access
Scientific Reports, volume 13, issue 1, publication number 13428
Antimicrobial and mechanical assessment of cellulose-based thermoformable material for invisible dental braces with natural essential oils protecting from biofilm formation
Monika Astasov Frauenhoffer
1
,
Livia Göldi
1
,
Nadja Rohr
1
,
Sarah Worreth
2
,
Elise Dard
3
,
Selina Hünerfauth
3
,
Tino Töpper
3
,
Jonas Zurflüh
4
,
Olivier Braissant
2
3
Bottmedical AG Technologiepark Basel, Basel, Switzerland
|
Publication type: Journal Article
Publication date: 2023-08-18
Journal:
Scientific Reports
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4.6
ISSN: 20452322, 20452322
Multidisciplinary
Abstract
Controlling biofilm formation in the oral cavity during orthodontic treatments is crucial. Therefore, antimicrobial surfaces for invisible dental appliances are of interest to both therapists and patients. Here we present a cellulose-based thermoformable material used for invisible braces that can be loaded with essential oils (EOs) having antibacterial and antifungal properties. We hypothesize that this material can absorb and release EOs, thus providing an antimicrobial effect without compromising the safety and mechanical properties necessary for dental invisible braces. Conventional microbiology and isothermal microcalorimetry analyses revealed that the thermoformable material loaded with essential oils significantly delayed the biofilm formation of oral streptococci (S. mutans and S. mitis) under static conditions (p < 0.05) and while simulating saliva flow (p < 0.05). In addition, cytotoxicity tests (ISO 10993-5), revealed that the loaded material is well tolerated by human gingival fibroblasts. Finally, the loading with antibacterial agents did not significantly alter the mechanical properties and stability of the material (initial force (p = 0.916); initial stress (p = 0.465)). Compared to gold-standard clear aligner materials, this material offers a reliable transmission of forces for orthodontic treatments. Moreover, this approach exhibits the potential for acting as an oral drug delivery platform for multiple compounds.
Top-30
Citations by journals
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1
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Russian Chemical Reviews
1 publication, 100%
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1
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Citations by publishers
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1
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 100%
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1
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Astasov Frauenhoffer M. et al. Antimicrobial and mechanical assessment of cellulose-based thermoformable material for invisible dental braces with natural essential oils protecting from biofilm formation // Scientific Reports. 2023. Vol. 13. No. 1. 13428
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Astasov Frauenhoffer M., Göldi L., Rohr N., Worreth S., Dard E., Hünerfauth S., Töpper T., Zurflüh J., Braissant O. Antimicrobial and mechanical assessment of cellulose-based thermoformable material for invisible dental braces with natural essential oils protecting from biofilm formation // Scientific Reports. 2023. Vol. 13. No. 1. 13428
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TY - JOUR
DO - 10.1038/s41598-023-39320-1
UR - https://doi.org/10.1038/s41598-023-39320-1
TI - Antimicrobial and mechanical assessment of cellulose-based thermoformable material for invisible dental braces with natural essential oils protecting from biofilm formation
T2 - Scientific Reports
AU - Astasov Frauenhoffer, Monika
AU - Göldi, Livia
AU - Rohr, Nadja
AU - Worreth, Sarah
AU - Dard, Elise
AU - Hünerfauth, Selina
AU - Töpper, Tino
AU - Zurflüh, Jonas
AU - Braissant, Olivier
PY - 2023
DA - 2023/08/18 00:00:00
PB - Springer Nature
IS - 1
VL - 13
SN - 2045-2322
SN - 2045-2322
ER -
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@article{2023_Astasov Frauenhoffer,
author = {Monika Astasov Frauenhoffer and Livia Göldi and Nadja Rohr and Sarah Worreth and Elise Dard and Selina Hünerfauth and Tino Töpper and Jonas Zurflüh and Olivier Braissant},
title = {Antimicrobial and mechanical assessment of cellulose-based thermoformable material for invisible dental braces with natural essential oils protecting from biofilm formation},
journal = {Scientific Reports},
year = {2023},
volume = {13},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1038/s41598-023-39320-1},
number = {1},
doi = {10.1038/s41598-023-39320-1}
}