Open Access

Scientific Reports, volume 6, issue 1, publication number 21734

Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization

Istrate Andrey N ¹

Kozin Sergey A. ¹

Zhokhov Sergey S ²

Mantsyzov Alexey B ²

Kechko Olga I. ¹

Pastore Annalisa ³

Makarov Alexander A. ¹

Polshakov Vladimir I ²

Hide authors affiliations Show authors affiliations: 3 affiliations

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia |

Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia |

The Wohl Institute, King’s College London, London, UK |

Publication type: Journal Article

Publication date: 2016-02-22

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/srep21734

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PubMed ID: 26898943

Multidisciplinary

Abstract

Conformational changes of Aβ peptide result in its transformation from native monomeric state to the toxic soluble dimers, oligomers and insoluble aggregates that are hallmarks of Alzheimer’s disease (AD). Interactions of zinc ions with Aβ are mediated by the N-terminal Aβ1–16 domain and appear to play a key role in AD progression. There is a range of results indicating that these interactions trigger the Aβ plaque formation. We have determined structure and functional characteristics of the metal binding domains derived from several Aβ variants and found that their zinc-induced oligomerization is governed by conformational changes in the minimal zinc binding site 6HDSGYEVHH14. The residue H6 and segment 11EVHH14, which are part of this site are crucial for formation of the two zinc-mediated interaction interfaces in Aβ. These structural determinants can be considered as promising targets for rational design of the AD-modifying drugs aimed at blocking pathological Aβ aggregation.

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Citations by journals

	1 2 3 4
Molecular Biology	Molecular Biology, 4, 5.33% Molecular Biology 4 publications, 5.33%
Journal of Alzheimer's Disease	Journal of Alzheimer's Disease, 4, 5.33% Journal of Alzheimer's Disease 4 publications, 5.33%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 5.33% International Journal of Molecular Sciences 4 publications, 5.33%
Biochemistry (Moscow)	Biochemistry (Moscow), 3, 4% Biochemistry (Moscow) 3 publications, 4%
Biomolecules	Biomolecules, 3, 4% Biomolecules 3 publications, 4%
Scientific Reports	Scientific Reports, 2, 2.67% Scientific Reports 2 publications, 2.67%
Coordination Chemistry Reviews	Coordination Chemistry Reviews, 2, 2.67% Coordination Chemistry Reviews 2 publications, 2.67%
Computational Biology and Chemistry	Computational Biology and Chemistry, 2, 2.67% Computational Biology and Chemistry 2 publications, 2.67%
Journal of Electroanalytical Chemistry	Journal of Electroanalytical Chemistry, 2, 2.67% Journal of Electroanalytical Chemistry 2 publications, 2.67%
ACS Chemical Neuroscience	ACS Chemical Neuroscience, 2, 2.67% ACS Chemical Neuroscience 2 publications, 2.67%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 1, 1.33% Angewandte Chemie - International Edition 1 publication, 1.33%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 1.33% Russian Chemical Reviews 1 publication, 1.33%
Journal of Biological Inorganic Chemistry	Journal of Biological Inorganic Chemistry, 1, 1.33% Journal of Biological Inorganic Chemistry 1 publication, 1.33%
Mass Spectrometry Reviews	Mass Spectrometry Reviews, 1, 1.33% Mass Spectrometry Reviews 1 publication, 1.33%
Heliyon	Heliyon, 1, 1.33% Heliyon 1 publication, 1.33%
Proceedings of SPIE - The International Society for Optical Engineering	Proceedings of SPIE - The International Society for Optical Engineering, 1, 1.33% Proceedings of SPIE - The International Society for Optical Engineering 1 publication, 1.33%
Current Drug Targets	Current Drug Targets, 1, 1.33% Current Drug Targets 1 publication, 1.33%
Aging	Aging, 1, 1.33% Aging 1 publication, 1.33%
Molecules	Molecules, 1, 1.33% Molecules 1 publication, 1.33%
Cells	Cells, 1, 1.33% Cells 1 publication, 1.33%
Pharmaceutics	Pharmaceutics, 1, 1.33% Pharmaceutics 1 publication, 1.33%
Frontiers in Molecular Neuroscience	Frontiers in Molecular Neuroscience, 1, 1.33% Frontiers in Molecular Neuroscience 1 publication, 1.33%
Frontiers in Neuroscience	Frontiers in Neuroscience, 1, 1.33% Frontiers in Neuroscience 1 publication, 1.33%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 1.33% Frontiers in Bioengineering and Biotechnology 1 publication, 1.33%
Pharmaceutical Research	Pharmaceutical Research, 1, 1.33% Pharmaceutical Research 1 publication, 1.33%
Protein Journal	Protein Journal, 1, 1.33% Protein Journal 1 publication, 1.33%
Neurotoxicity Research	Neurotoxicity Research, 1, 1.33% Neurotoxicity Research 1 publication, 1.33%
International Journal of Peptide Research and Therapeutics	International Journal of Peptide Research and Therapeutics, 1, 1.33% International Journal of Peptide Research and Therapeutics 1 publication, 1.33%
Journal of Molecular Liquids	Journal of Molecular Liquids, 1, 1.33% Journal of Molecular Liquids 1 publication, 1.33%
Biomaterials	Biomaterials, 1, 1.33% Biomaterials 1 publication, 1.33%
	1 2 3 4

Citations by publishers

	2 4 6 8 10 12 14 16
Elsevier	Elsevier, 15, 20% Elsevier 15 publications, 20%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 10, 13.33% Multidisciplinary Digital Publishing Institute (MDPI) 10 publications, 13.33%
Wiley	Wiley, 9, 12% Wiley 9 publications, 12%
Pleiades Publishing	Pleiades Publishing, 8, 10.67% Pleiades Publishing 8 publications, 10.67%
Springer Nature	Springer Nature, 8, 10.67% Springer Nature 8 publications, 10.67%
American Chemical Society (ACS)	American Chemical Society (ACS), 6, 8% American Chemical Society (ACS) 6 publications, 8%
IOS Press	IOS Press, 4, 5.33% IOS Press 4 publications, 5.33%
Frontiers Media S.A.	Frontiers Media S.A., 3, 4% Frontiers Media S.A. 3 publications, 4%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 4% Royal Society of Chemistry (RSC) 3 publications, 4%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 1.33% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 1.33%
SPIE	SPIE, 1, 1.33% SPIE 1 publication, 1.33%
Bentham Science	Bentham Science, 1, 1.33% Bentham Science 1 publication, 1.33%
Impact Journals	Impact Journals, 1, 1.33% Impact Journals 1 publication, 1.33%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 1.33% American Society for Biochemistry and Molecular Biology 1 publication, 1.33%
International Society on Aging and Disease	International Society on Aging and Disease, 1, 1.33% International Society on Aging and Disease 1 publication, 1.33%
Taylor & Francis	Taylor & Francis, 1, 1.33% Taylor & Francis 1 publication, 1.33%
Walter de Gruyter	Walter de Gruyter, 1, 1.33% Walter de Gruyter 1 publication, 1.33%
	2 4 6 8 10 12 14 16

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Istrate A. N. et al. Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization // Scientific Reports. 2016. Vol. 6. No. 1. 21734

GOST all authors (up to 50) Copy

Istrate A. N., Kozin S. A., Zhokhov S. S., Mantsyzov A. B., Kechko O. I., Pastore A., Makarov A. A., Polshakov V. I. Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization // Scientific Reports. 2016. Vol. 6. No. 1. 21734

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/srep21734

UR - https://doi.org/10.1038%2Fsrep21734

TI - Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization

T2 - Scientific Reports

AU - Istrate, Andrey N

AU - Kechko, Olga I.

AU - Pastore, Annalisa

AU - Makarov, Alexander A.

AU - Polshakov, Vladimir I

AU - Kozin, Sergey A.

AU - Zhokhov, Sergey S

AU - Mantsyzov, Alexey B

PY - 2016

DA - 2016/02/22 00:00:00

PB - Springer Nature

IS - 1

VL - 6

PMID - 26898943

SN - 2045-2322

ER -

BibTex

Cite this

BibTex Copy

@article{2016_Istrate,

author = {Andrey N Istrate and Olga I. Kechko and Annalisa Pastore and Alexander A. Makarov and Vladimir I Polshakov and Sergey A. Kozin and Sergey S Zhokhov and Alexey B Mantsyzov},

title = {Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization},

journal = {Scientific Reports},

year = {2016},

volume = {6},

publisher = {Springer Nature},

month = {feb},

url = {https://doi.org/10.1038%2Fsrep21734},

number = {1},

doi = {10.1038/srep21734}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

Labs

Laboratory of Magnetic Tomography and Spectroscopy

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