Laboratory of Magnetic Tomography and Spectroscopy
Head of Laboratory
Khokhlov, Alexei R
DSc in Physics and Mathematics, Professor, Full member of the Russian Academy of Sciences
Publications
822
Citations
20 701
h-index
70
Authorization required.
· Determination of the structure of physiologically active compounds by NMR spectroscopy;
· Determination of the structure of proteins and nucleic acids in solution by multidimensional heteronuclear NMR spectroscopy;
· The study of protein dynamics by NMR methods;
· NMR studies of protein-protein and protein-ligand interactions;
· Search and design of biologically active compounds by NMR screening methods;
· The study of the physiological state of the human and animal body by NMR-metabolomics methods;
· Magnetic resonance imaging of small laboratory animals;
· Multicore (1H, 2D, 13C, 31P, 19F, 23Na) in vivo NMR spectroscopy.
- NMR spectroscopy of liquids (1D, 2D, 3D);
- NMR spectroscopy of solids with rotation of samples at a magic angle
- In vivo NMR spectroscopy on laboratory animals
- Magnetic resonance imaging
- Molecular dynamics and quantum chemical calculations
- Recombinant protein expression
- Cloning
- Organic synthesis
- NMR spectroscopy
- Gel electrophoresis
Alexei Khokhlov
Head of Laboratory
Vladimir Polshakov
Leading researcher
Mikhail Gulyaev
Senior Researcher
Nikolay Anisimov
Senior Researcher
Alexey Mantsyzov
Researcher
Olga Pavlova
Researcher
Oleg Savelyev
Engineer
Roman Roman
PhD student
Research directions
Development and synthesis of spin labels for the study of methyltransferases
Design by NMR screening of inorganic pyrophosphatase and formate dehydrogenase inhibitors - potential antibacterial agents
Investigation of the structure in solution and dynamic properties of inorganic pyrophosphatase from Mycobacterium tuberculosis and Staphylococcus aureus formate dehydrogenase
Determination of human vitamin status according to NMR-metabolomics data
Determination of the structure of new physiologically active compounds (antibiotics, antifungal and anticancer drugs).
Study of the structure and properties of the Clamp protein, a factor regulating dose compensation in drosophila
The study of zinc-dependent oligomerization of β-amyloid peptide associated with the development of Alzheimer's disease
Study of the structure and properties of telomerase proteins of thermophilic yeast Hansenula polymorpha
Determination of the structure and properties of WBSCR27 methyltransferase associated with Williams syndrome
Investigation of the structure in solution and dynamic properties of inorganic pyrophosphatase from Mycobacterium tuberculosis and Staphylococcus aureus formate dehydrogenase
Publications and patents
Лесив А. В., Ивашкин П. Е., Гуляев М. В., Дорофеева Е. О., Косенков А. В., Киселевский М. В., Польшаков В. И.
RU2663286,
2018
Левшин И. Б., Польшаков В. И., Грамматикова Н. Э., Сандуленко Ю. Б.
RU2662153,
2018
Базыленко Т. Ю., Гуляев М. В., Добринский Э. К., Зиновьев С. В., Зубов В. П., Ищенко А. А., Каргина Ю. В., Ольхов А. А., Пирогов Ю. А., Паршуткин А. Е., Савилов С. В., Тимошенко В. Ю., Харин А. Ю., Шаронова Н. В.
RU2701106,
2019
2022
—
2023
| Польшаков Владимир Иванович
2019
—
2021
| Польшаков Владимир Иванович
2017
—
2018
| Польшаков Владимир Иванович
2014
—
2016
| Польшаков Владимир Иванович
Lab address
Ленинские горы, дом 1, строение 73
Authorization required.