Laboratory of Magnetic Tomography and Spectroscopy

Head of Laboratory

Khokhlov, Alexei R

DSc in Physics and Mathematics, Professor, Full member of the Russian Academy of Sciences 
Publications
822
Citations
20 701
h-index
70
Authorization required.

· Determination of the structure of physiologically active compounds by NMR spectroscopy;

· Determination of the structure of proteins and nucleic acids in solution by multidimensional heteronuclear NMR spectroscopy;

· The study of protein dynamics by NMR methods;

· NMR studies of protein-protein and protein-ligand interactions;

· Search and design of biologically active compounds by NMR screening methods;

· The study of the physiological state of the human and animal body by NMR-metabolomics methods;

· Magnetic resonance imaging of small laboratory animals;

· Multicore (1H, 2D, 13C, 31P, 19F, 23Na) in vivo NMR spectroscopy.

  1. NMR spectroscopy of liquids (1D, 2D, 3D);
  2. NMR spectroscopy of solids with rotation of samples at a magic angle
  3. In vivo NMR spectroscopy on laboratory animals
  4. Magnetic resonance imaging
  5. Molecular dynamics and quantum chemical calculations
  6. Recombinant protein expression
  7. Cloning
  8. Organic synthesis
  9. NMR spectroscopy
  10. Gel electrophoresis
Alexei Khokhlov
Head of Laboratory
Vladimir Polshakov
Leading researcher
Gulyaev, Mikhail Vladimirovich
Mikhail Gulyaev
Senior Researcher
Anisimov, Nikolay V
Nikolay Anisimov
Senior Researcher
Pavlova, Olga S
Olga Pavlova
Researcher
Sofia Mariasina 🥼 🤝
Researcher
Roman, Roman S
Roman Roman
PhD student

Research directions

Development and synthesis of spin labels for the study of methyltransferases

Design by NMR screening of inorganic pyrophosphatase and formate dehydrogenase inhibitors - potential antibacterial agents

Investigation of the structure in solution and dynamic properties of inorganic pyrophosphatase from Mycobacterium tuberculosis and Staphylococcus aureus formate dehydrogenase

Determination of human vitamin status according to NMR-metabolomics data

Determination of the structure of new physiologically active compounds (antibiotics, antifungal and anticancer drugs).

Study of the structure and properties of the Clamp protein, a factor regulating dose compensation in drosophila

The study of zinc-dependent oligomerization of β-amyloid peptide associated with the development of Alzheimer's disease

Study of the structure and properties of telomerase proteins of thermophilic yeast Hansenula polymorpha

Determination of the structure and properties of WBSCR27 methyltransferase associated with Williams syndrome

Investigation of the structure in solution and dynamic properties of inorganic pyrophosphatase from Mycobacterium tuberculosis and Staphylococcus aureus formate dehydrogenase

Publications and patents

Базыленко Т. Ю., Гуляев М. В., Добринский Э. К., Зиновьев С. В., Зубов В. П., Ищенко А. А., Каргина Ю. В., Ольхов А. А., Пирогов Ю. А., Паршуткин А. Е., Савилов С. В., Тимошенко В. Ю., Харин А. Ю., Шаронова Н. В.
RU2701106, 2019

Lab address

Ленинские горы, дом 1, строение 73
Authorization required.