Open Access

RSC Advances

, volume 10 , issue 73 , pages 45059-45066

pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery

Huan Peng ^{1, 2, 3, 4, 5, 6, 7}

Weihong Ji ^{1, 2, 3, 4, 5, 6, 7}

Ruichen Zhao ^{1, 2, 3, 4, 5, 6, 7}

ZHIGUO LÜ ^{1, 2}

Zhiguo Lu ^{1, 2, 3, 4, 5, 6, 7}

Jun Yang ¹

Yan Li ¹

Xin Zhang ^{1, 3, 4, 5, 6, 7}

Hide authors affiliations Show authors affiliations: 7 affiliations

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China |

University of Chinese Academy of Sciences, BeiJing, China |

State Key Laboratory of Biochemical Engineering

⁴

Institute of Process Engineering

⁵

Chinese Academy of sciences

⁶

Beijing |

⁷

CHINA |

Publication type: Journal Article

Publication date: 2020-12-21

Royal Society of Chemistry (RSC)

RSC Advances

scimago Q1

wos Q2

SJR: 0.777

CiteScore: 7.6

Impact factor: 4.6

ISSN: 20462069

DOI: 10.1039/d0ra09359a

Copy DOI

PubMed ID: 35516239

General Chemistry

General Chemical Engineering

Abstract

Small interfering RNA (siRNA) has great potential for the treatment of various diseases. However, its intrinsic deficiencies seriously limit its application. Herein, pH-sensitive zwitterionic polymer polycarboxybetaine (PCB) was developed as a non-viral vector for siRNA. The PCB could be protonated in an acidic environment and become positively charged from a cancer site. After protonation, PCB could complex siRNA via electrostatic interaction, and its loading ability was enhanced with a decrease of pH value. Compared with the PEI 10k, PCB50 with a similar molecular weight had comparable siRNA loading ability and lower cytotoxicity. Besides, siRNA loaded by PCB50 could escape from endosomes and reduce the loss of drugs, and based on the excellent uptake and obvious apoptotic effect on HeLa cells, the pH-sensitive PCB with low cytotoxicity could be used as a non-viral vector for safe siRNA delivery for cancer treatment.

Found

1 citation

Gaynanova Gulnara

PhD in Chemistry

74 publications, 1 073 citations, 1 review

h-index: 18

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Supramolecular chemistry

Surfactants

1 citation

Vasilyeva Leysan

PhD in Chemistry

29 publications, 492 citations

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Surfactants

1 citation

Zakharova Lucia

DSc in Chemistry, professor

394 publications, 6 176 citations

h-index: 36

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

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GOST |

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GOST Copy

Peng H. et al. pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery // RSC Advances. 2020. Vol. 10. No. 73. pp. 45059-45066.

GOST all authors (up to 50) Copy

Peng H., Ji W., Zhao R., LÜ Z., Lu Z., Yang J., Li Y., Zhang X. pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery // RSC Advances. 2020. Vol. 10. No. 73. pp. 45059-45066.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1039/d0ra09359a

UR - https://xlink.rsc.org/?DOI=D0RA09359A

TI - pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery

T2 - RSC Advances

AU - Peng, Huan

AU - Ji, Weihong

AU - Zhao, Ruichen

AU - LÜ, ZHIGUO

AU - Lu, Zhiguo

AU - Yang, Jun

AU - Li, Yan

AU - Zhang, Xin

PY - 2020

DA - 2020/12/21

PB - Royal Society of Chemistry (RSC)

SP - 45059-45066

IS - 73

VL - 10

PMID - 35516239

SN - 2046-2069

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Peng,

author = {Huan Peng and Weihong Ji and Ruichen Zhao and ZHIGUO LÜ and Zhiguo Lu and Jun Yang and Yan Li and Xin Zhang},

title = {pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery},

journal = {RSC Advances},

year = {2020},

volume = {10},

publisher = {Royal Society of Chemistry (RSC)},

month = {dec},

url = {https://xlink.rsc.org/?DOI=D0RA09359A},

number = {73},

pages = {45059--45066},

doi = {10.1039/d0ra09359a}

}

MLA

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MLA Copy

Peng, Huan, et al. “pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery.” RSC Advances, vol. 10, no. 73, Dec. 2020, pp. 45059-45066. https://xlink.rsc.org/?DOI=D0RA09359A.

Publisher

Royal Society of Chemistry (RSC)

Journal

RSC Advances

scimago Q1

wos Q2

SJR

0.777

CiteScore

7.6

Impact factor

4.6

ISSN

20462069 (Print, Electronic)