Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib
1
Publication type: Journal Article
Publication date: 2021-08-02
scimago Q2
wos Q2
SJR: 0.600
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
PubMed ID:
34351339
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
A convenient and scalable base-free method for processing [18F]fluoride as [18F]TBAF is reported and applied to copper-mediated radiofluorination radiosyntheses. A central feature of this method is that a single production of [18F]TBAF can be divided into small aliquots that can be used to perform multiple small-scale reactions in DoE optimization studies. The results of these studies can then be reliably translated to full batch tracer productions using automated synthesizers. The processing method was applied to the DoE optimization of [18F]olaparib, affording the tracer in high radiochemical yields via both manual (%RCY = 78 ± 6%, n = 4 (CMRF step only)) and automated (up to 80% (%RCY); 41% activity yield (%AY)) radiosynthesis procedures.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
European Journal of Medicinal Chemistry
2 publications, 7.69%
|
|
|
EJNMMI Radiopharmacy and Chemistry
2 publications, 7.69%
|
|
|
Chemistry - A European Journal
1 publication, 3.85%
|
|
|
Pharmaceuticals
1 publication, 3.85%
|
|
|
Cancers
1 publication, 3.85%
|
|
|
Journal of Organometallic Chemistry
1 publication, 3.85%
|
|
|
Journal of Labelled Compounds and Radiopharmaceuticals
1 publication, 3.85%
|
|
|
Journal of Medicinal Chemistry
1 publication, 3.85%
|
|
|
Organic Chemistry Frontiers
1 publication, 3.85%
|
|
|
European Journal of Nuclear Medicine and Molecular Imaging
1 publication, 3.85%
|
|
|
Pharmaceutics
1 publication, 3.85%
|
|
|
ACS Medicinal Chemistry Letters
1 publication, 3.85%
|
|
|
Bioconjugate Chemistry
1 publication, 3.85%
|
|
|
Journal of the American Chemical Society
1 publication, 3.85%
|
|
|
Journal of Clinical Medicine
1 publication, 3.85%
|
|
|
European Journal of Organic Chemistry
1 publication, 3.85%
|
|
|
Expert Review of Anticancer Therapy
1 publication, 3.85%
|
|
|
Synthesis
1 publication, 3.85%
|
|
|
npj Imaging
1 publication, 3.85%
|
|
|
Organic Letters
1 publication, 3.85%
|
|
|
Current Radiopharmaceuticals
1 publication, 3.85%
|
|
|
Organic and Biomolecular Chemistry
1 publication, 3.85%
|
|
|
1
2
|
Publishers
|
1
2
3
4
5
6
|
|
|
Springer Nature
6 publications, 23.08%
|
|
|
American Chemical Society (ACS)
5 publications, 19.23%
|
|
|
MDPI
4 publications, 15.38%
|
|
|
Wiley
3 publications, 11.54%
|
|
|
Elsevier
3 publications, 11.54%
|
|
|
Royal Society of Chemistry (RSC)
2 publications, 7.69%
|
|
|
Taylor & Francis
1 publication, 3.85%
|
|
|
Georg Thieme Verlag KG
1 publication, 3.85%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 3.85%
|
|
|
1
2
3
4
5
6
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
26
Total citations:
26
Citations from 2024:
14
(53%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Bowden G. et al. Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib // Organic and Biomolecular Chemistry. 2021. Vol. 19. No. 32. pp. 6995-7000.
GOST all authors (up to 50)
Copy
Bowden G., Chailanggar N., Pichler B. J., Maurer A. Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib // Organic and Biomolecular Chemistry. 2021. Vol. 19. No. 32. pp. 6995-7000.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/d1ob00903f
UR - https://xlink.rsc.org/?DOI=D1OB00903F
TI - Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib
T2 - Organic and Biomolecular Chemistry
AU - Bowden, Gregory
AU - Chailanggar, Nantanat
AU - Pichler, Bernd J.
AU - Maurer, Andreas
PY - 2021
DA - 2021/08/02
PB - Royal Society of Chemistry (RSC)
SP - 6995-7000
IS - 32
VL - 19
PMID - 34351339
SN - 1477-0520
SN - 1477-0539
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Bowden,
author = {Gregory Bowden and Nantanat Chailanggar and Bernd J. Pichler and Andreas Maurer},
title = {Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib},
journal = {Organic and Biomolecular Chemistry},
year = {2021},
volume = {19},
publisher = {Royal Society of Chemistry (RSC)},
month = {aug},
url = {https://xlink.rsc.org/?DOI=D1OB00903F},
number = {32},
pages = {6995--7000},
doi = {10.1039/d1ob00903f}
}
Cite this
MLA
Copy
Bowden, Gregory, et al. “Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib.” Organic and Biomolecular Chemistry, vol. 19, no. 32, Aug. 2021, pp. 6995-7000. https://xlink.rsc.org/?DOI=D1OB00903F.