Organic and Biomolecular Chemistry, volume 22, issue 26, pages 5406-5413

Development of an efficient and scalable bioprocess for the plant hormone 12-OPDA: Overcoming hurdles of nature´s biosynthesis

Publication type: Journal Article
Publication date: 2024-04-29
scimago Q2
SJR: 0.607
CiteScore: 5.5
Impact factor: 2.9
ISSN: 14770520, 14770539
Abstract

A biocatalytic cascade synthesis of cis-(+)-12-OPDA at 5–20 gL−1 substrate loading was developed, leading to excellent conversion, chemical purity (>99%), enantio- and diastereomeric excess (>99% ee, 96% de) as well as neglectable side-product (<1%).

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