Structure–reactivity relationships in the inactivation of elastase by β-sultams
Тип публикации: Journal Article
Дата публикации: 2003-01-01
scimago Q2
wos Q2
БС1
SJR: 0.6
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
PubMed ID:
12929392
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Краткое описание
N-Acyl-beta-sultams are time dependent irreversible active site directed inhibitors of elastase. The rate of inactivation is first order with respect to beta-sultam concentration and the second order rate constants show a similar dependence on pH to that for the hydrolysis of a peptide substrate. Inactivation is due to the formation of a stable 1:1 enzyme inhibitor complex as a result of the active site serine being sulfonylated by the beta-sultam. Ring opening of the beta-sultam occurs by S-N fission in contrast to the C-N fission observed in the acylation of elastase by N-acylsulfonamides. Structure-activity effects are compared between sulfonylation of the enzyme and alkaline hydrolysis. Variation in 4-alkyl and N-substituted beta-sultams causes differences in the rates of inactivation by 4 orders of magnitude.
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Hinchliffe P. S. et al. Structure–reactivity relationships in the inactivation of elastase by β-sultams // Organic and Biomolecular Chemistry. 2003. Vol. 1. No. 1. pp. 67-80.
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Hinchliffe P. S., Wood J., Davis A. L., Austin R. P., Beckett R., Page M. Structure–reactivity relationships in the inactivation of elastase by β-sultams // Organic and Biomolecular Chemistry. 2003. Vol. 1. No. 1. pp. 67-80.
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TY - JOUR
DO - 10.1039/b208079f
UR - https://doi.org/10.1039/b208079f
TI - Structure–reactivity relationships in the inactivation of elastase by β-sultams
T2 - Organic and Biomolecular Chemistry
AU - Hinchliffe, Paul S
AU - Wood, J.Matthew
AU - Davis, Andrew L.
AU - Austin, Rupert P
AU - Beckett, R.Paul
AU - Page, Michael
PY - 2003
DA - 2003/01/01
PB - Royal Society of Chemistry (RSC)
SP - 67-80
IS - 1
VL - 1
PMID - 12929392
SN - 1477-0520
SN - 1477-0539
ER -
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@article{2003_Hinchliffe,
author = {Paul S Hinchliffe and J.Matthew Wood and Andrew L. Davis and Rupert P Austin and R.Paul Beckett and Michael Page},
title = {Structure–reactivity relationships in the inactivation of elastase by β-sultams},
journal = {Organic and Biomolecular Chemistry},
year = {2003},
volume = {1},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/b208079f},
number = {1},
pages = {67--80},
doi = {10.1039/b208079f}
}
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MLA
Скопировать
Hinchliffe, Paul S., et al. “Structure–reactivity relationships in the inactivation of elastase by β-sultams.” Organic and Biomolecular Chemistry, vol. 1, no. 1, Jan. 2003, pp. 67-80. https://doi.org/10.1039/b208079f.