The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity
Publication type: Journal Article
Publication date: 2013-07-24
scimago Q1
wos Q2
SJR: 1.037
CiteScore: 7.4
Impact factor: 4.2
ISSN: 13597345, 1364548X
PubMed ID:
23939654
Materials Chemistry
Metals and Alloys
Surfaces, Coatings and Films
General Chemistry
Ceramics and Composites
Electronic, Optical and Magnetic Materials
Catalysis
Abstract
An original, effective approach to the synthesis of natural and synthetic 5Z,9Z-dienoic acids in high yields (61-67%) and with high selectivity (>98%) was developed. The approach is based on the use of the new intermolecular catalytic cross cyclomagnesiation of terminal aliphatic and oxygenated 1,2-dienes upon treatment with Grignard reagents in the presence of the Cp2TiCl2 catalyst. High activity of (5Z,9Z)-5,9-eicosadienoic acid as a human topoisomerase I inhibitor at concentrations above 0.1 μM was elucidated.
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Metrics
63
Total citations:
63
Citations from 2024:
7
(11.11%)
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GOST
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D'yakonov V. A. et al. The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity // Chemical Communications. 2013. Vol. 49. No. 75. p. 8401.
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D'yakonov V. A., Makarov A. A., Dzhemileva L. U., Makarova E. Kh., Khusnutdinova E. K., Dzhemilev U. M. The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity // Chemical Communications. 2013. Vol. 49. No. 75. p. 8401.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c3cc44926b
UR - https://doi.org/10.1039/c3cc44926b
TI - The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity
T2 - Chemical Communications
AU - D'yakonov, Vladimir A
AU - Makarov, Aleksey A
AU - Dzhemileva, Lilya U.
AU - Makarova, Elina Kh
AU - Khusnutdinova, E. K.
AU - Dzhemilev, Usein M
PY - 2013
DA - 2013/07/24
PB - Royal Society of Chemistry (RSC)
SP - 8401
IS - 75
VL - 49
PMID - 23939654
SN - 1359-7345
SN - 1364-548X
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_D'yakonov,
author = {Vladimir A D'yakonov and Aleksey A Makarov and Lilya U. Dzhemileva and Elina Kh Makarova and E. K. Khusnutdinova and Usein M Dzhemilev},
title = {The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity},
journal = {Chemical Communications},
year = {2013},
volume = {49},
publisher = {Royal Society of Chemistry (RSC)},
month = {jul},
url = {https://doi.org/10.1039/c3cc44926b},
number = {75},
pages = {8401},
doi = {10.1039/c3cc44926b}
}
Cite this
MLA
Copy
D'yakonov, Vladimir A., et al. “The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity.” Chemical Communications, vol. 49, no. 75, Jul. 2013, p. 8401. https://doi.org/10.1039/c3cc44926b.