The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells
Lilya U. Dzhemileva
1, 2
,
Aleksey A Makarov
1
,
Evgeny N Andreev
1
,
Milyausha M. Yunusbaeva
1
,
Usein M Dzhemilev
1
Publication type: Journal Article
Publication date: 2017-01-01
scimago Q2
wos Q2
SJR: 0.600
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
PubMed ID:
27929178
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
The communication reports a new stereoselective method for the synthesis of a natural acetylenic alcohol, lembehyne B. The key stage of the process uses new cross-cyclomagnesiation reaction of aliphatic and oxygenated 1,2-dienes with Grignard reagents in the presence of a catalytic amount of Cp2TiCl2. A study of the cytotoxic properties of lembehyne B on tumor cell lines using flow cytometry demonstrated that this is a selective inducer of early apoptosis of the Jurkat, HL-60 and K562 cell cultures and hypodiploid (sub-G1) sub-population inducer in cell cycle studies for all cell lines used.
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21
Total citations:
21
Citations from 2024:
1
(4.76%)
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GOST
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Dzhemileva L. U. et al. The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells // Organic and Biomolecular Chemistry. 2017. Vol. 15. No. 2. pp. 470-476.
GOST all authors (up to 50)
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Dzhemileva L. U., D'yakonov V. A., Makarov A. A., Andreev E. N., Yunusbaeva M. M., Dzhemilev U. M. The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells // Organic and Biomolecular Chemistry. 2017. Vol. 15. No. 2. pp. 470-476.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c6ob02346k
UR - https://doi.org/10.1039/c6ob02346k
TI - The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells
T2 - Organic and Biomolecular Chemistry
AU - Dzhemileva, Lilya U.
AU - D'yakonov, Vladimir A
AU - Makarov, Aleksey A
AU - Andreev, Evgeny N
AU - Yunusbaeva, Milyausha M.
AU - Dzhemilev, Usein M
PY - 2017
DA - 2017/01/01
PB - Royal Society of Chemistry (RSC)
SP - 470-476
IS - 2
VL - 15
PMID - 27929178
SN - 1477-0520
SN - 1477-0539
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Dzhemileva,
author = {Lilya U. Dzhemileva and Vladimir A D'yakonov and Aleksey A Makarov and Evgeny N Andreev and Milyausha M. Yunusbaeva and Usein M Dzhemilev},
title = {The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells},
journal = {Organic and Biomolecular Chemistry},
year = {2017},
volume = {15},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/c6ob02346k},
number = {2},
pages = {470--476},
doi = {10.1039/c6ob02346k}
}
Cite this
MLA
Copy
Dzhemileva, Lilya U., et al. “The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells.” Organic and Biomolecular Chemistry, vol. 15, no. 2, Jan. 2017, pp. 470-476. https://doi.org/10.1039/c6ob02346k.