Supramolecular prodrugs based on host-guest interactions.
Wen Chao Geng
1, 2
,
Wen-Chao Geng
1, 2, 3, 4, 5, 6, 7
,
Jonathan Sessler
2, 8, 9, 10, 11
,
Dong-Sheng Guo
1, 3, 4, 5, 6, 7
3
College of Chemistry
4
Key Laboratory of Functional Polymer Materials (Ministry of Education)
5
State Key Laboratory of Elemento-organic Chemistry
7
Tianjin 300071
|
8
DEPARTMENT OF CHEMISTRY
10
Austin
|
11
Usa
|
Publication type: Journal Article
Publication date: 2020-03-17
scimago Q1
wos Q1
SJR: 11.467
CiteScore: 73.2
Impact factor: 39.0
ISSN: 03060012, 14604744
PubMed ID:
32181453
General Chemistry
Abstract
Classic prodrug strategies rely on covalent modification of active drugs to provide systems with superior pharmacokinetic properties than the parent drug and facilitate administration. Supramolecular chemistry is providing a new approach to developing prodrug-like systems, wherein the characteristics of a drug are modified in a beneficial manner by creating host-guest complexes that then permit the stimulus-induced release of the active species in a controlled manner. These complexes are termed "supramolecular prodrugs". In this review, we outline the concept of supramolecular drugs via host-guest chemistry and detail progress made in the area. This summary is designed to highlight the many advantages of supramolecular prodrugs, including ease-of-preparation, molecular-level protection, sensitive response to bio-stimuli, traceless release, and adaptability to different drugs. Limitations of the approach and opportunities for future growth are also detailed.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
7
8
9
|
|
|
Angewandte Chemie - International Edition
9 publications, 4.31%
|
|
|
Angewandte Chemie
9 publications, 4.31%
|
|
|
Advanced Materials
7 publications, 3.35%
|
|
|
Chemical Communications
7 publications, 3.35%
|
|
|
Chemical Science
6 publications, 2.87%
|
|
|
Coordination Chemistry Reviews
6 publications, 2.87%
|
|
|
Chinese Chemical Letters
5 publications, 2.39%
|
|
|
Chemistry - A European Journal
5 publications, 2.39%
|
|
|
Journal of Medicinal Chemistry
5 publications, 2.39%
|
|
|
ACS applied materials & interfaces
5 publications, 2.39%
|
|
|
Journal of Molecular Liquids
4 publications, 1.91%
|
|
|
Molecules
4 publications, 1.91%
|
|
|
Advanced Science
4 publications, 1.91%
|
|
|
Aggregate
4 publications, 1.91%
|
|
|
Journal of the American Chemical Society
4 publications, 1.91%
|
|
|
Advanced healthcare materials
4 publications, 1.91%
|
|
|
Biomaterials
3 publications, 1.44%
|
|
|
Chemical Engineering Journal
3 publications, 1.44%
|
|
|
Advanced Functional Materials
3 publications, 1.44%
|
|
|
Small
3 publications, 1.44%
|
|
|
Biomacromolecules
3 publications, 1.44%
|
|
|
Chemical Society Reviews
3 publications, 1.44%
|
|
|
Nature Reviews Chemistry
3 publications, 1.44%
|
|
|
Journal of Controlled Release
3 publications, 1.44%
|
|
|
Pharmaceutics
2 publications, 0.96%
|
|
|
Journal of Nanobiotechnology
2 publications, 0.96%
|
|
|
Inorganic Chemistry
2 publications, 0.96%
|
|
|
Advanced NanoBiomed Research
2 publications, 0.96%
|
|
|
Molecular Pharmaceutics
2 publications, 0.96%
|
|
|
New Journal of Chemistry
2 publications, 0.96%
|
|
|
1
2
3
4
5
6
7
8
9
|
Publishers
|
10
20
30
40
50
60
70
|
|
|
Wiley
65 publications, 31.1%
|
|
|
Elsevier
45 publications, 21.53%
|
|
|
American Chemical Society (ACS)
34 publications, 16.27%
|
|
|
Royal Society of Chemistry (RSC)
32 publications, 15.31%
|
|
|
Springer Nature
11 publications, 5.26%
|
|
|
MDPI
8 publications, 3.83%
|
|
|
Taylor & Francis
4 publications, 1.91%
|
|
|
Proceedings of the National Academy of Sciences (PNAS)
2 publications, 0.96%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 0.48%
|
|
|
Mary Ann Liebert
1 publication, 0.48%
|
|
|
Frontiers Media S.A.
1 publication, 0.48%
|
|
|
Georg Thieme Verlag KG
1 publication, 0.48%
|
|
|
Hindawi Limited
1 publication, 0.48%
|
|
|
American Association for the Advancement of Science (AAAS)
1 publication, 0.48%
|
|
|
Science in China Press
1 publication, 0.48%
|
|
|
Hans Publishers
1 publication, 0.48%
|
|
|
10
20
30
40
50
60
70
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
210
Total citations:
210
Citations from 2024:
92
(44.02%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Geng W. C. et al. Supramolecular prodrugs based on host-guest interactions. // Chemical Society Reviews. 2020. Vol. 49. No. 8. pp. 2303-2315.
GOST all authors (up to 50)
Copy
Geng W. C., Geng W., Sessler J., Guo D. Supramolecular prodrugs based on host-guest interactions. // Chemical Society Reviews. 2020. Vol. 49. No. 8. pp. 2303-2315.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/C9CS00622B
UR - https://xlink.rsc.org/?DOI=C9CS00622B
TI - Supramolecular prodrugs based on host-guest interactions.
T2 - Chemical Society Reviews
AU - Geng, Wen Chao
AU - Geng, Wen-Chao
AU - Sessler, Jonathan
AU - Guo, Dong-Sheng
PY - 2020
DA - 2020/03/17
PB - Royal Society of Chemistry (RSC)
SP - 2303-2315
IS - 8
VL - 49
PMID - 32181453
SN - 0306-0012
SN - 1460-4744
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Geng,
author = {Wen Chao Geng and Wen-Chao Geng and Jonathan Sessler and Dong-Sheng Guo},
title = {Supramolecular prodrugs based on host-guest interactions.},
journal = {Chemical Society Reviews},
year = {2020},
volume = {49},
publisher = {Royal Society of Chemistry (RSC)},
month = {mar},
url = {https://xlink.rsc.org/?DOI=C9CS00622B},
number = {8},
pages = {2303--2315},
doi = {10.1039/C9CS00622B}
}
Cite this
MLA
Copy
Geng, Wen Chao, et al. “Supramolecular prodrugs based on host-guest interactions..” Chemical Society Reviews, vol. 49, no. 8, Mar. 2020, pp. 2303-2315. https://xlink.rsc.org/?DOI=C9CS00622B.
Profiles