Open Access
Open access
volume 10 issue 32 pages 7554-7560

α-Silicon effect assisted Curtin–Hammett allylation using allylcopper reagents derived from 1,3-dienylsilanes

Shang Gao 1, 2, 3, 4, 5
Ming Chen 1, 2, 3, 4, 5
Publication typeJournal Article
Publication date2019-06-28
scimago Q1
wos Q1
SJR2.138
CiteScore12.6
Impact factor7.4
ISSN20416520, 20416539
PubMed ID:  31489170
General Chemistry
Abstract
Cu-catalyzed stereoselective synthesis of (E)-δ-silyl-anti-homoallylic alcohols from 1,3-dienylsilane was developed. Mechanistic studies revealed that the borocupration of dienylsilane proceeded through a 1,2-addition pathway to give an allylcopper intermediate with Cu distal to the silyl group. However, the subsequent aldehyde allylation proceeded via Curtin–Hammett control to give (E)-δ-silyl-anti-homoallylic alcohols with high diastereoselectivities. This method was applied to the synthesis of the C1–9 fragment of a polyketide natural product, mycinolide IV.
Found 
Found 

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GOST |
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GOST Copy
Gao S. et al. α-Silicon effect assisted Curtin–Hammett allylation using allylcopper reagents derived from 1,3-dienylsilanes // Chemical Science. 2019. Vol. 10. No. 32. pp. 7554-7560.
GOST all authors (up to 50) Copy
Gao S., Chen M. α-Silicon effect assisted Curtin–Hammett allylation using allylcopper reagents derived from 1,3-dienylsilanes // Chemical Science. 2019. Vol. 10. No. 32. pp. 7554-7560.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1039/c9sc02905b
UR - https://xlink.rsc.org/?DOI=C9SC02905B
TI - α-Silicon effect assisted Curtin–Hammett allylation using allylcopper reagents derived from 1,3-dienylsilanes
T2 - Chemical Science
AU - Gao, Shang
AU - Chen, Ming
PY - 2019
DA - 2019/06/28
PB - Royal Society of Chemistry (RSC)
SP - 7554-7560
IS - 32
VL - 10
PMID - 31489170
SN - 2041-6520
SN - 2041-6539
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2019_Gao,
author = {Shang Gao and Ming Chen},
title = {α-Silicon effect assisted Curtin–Hammett allylation using allylcopper reagents derived from 1,3-dienylsilanes},
journal = {Chemical Science},
year = {2019},
volume = {10},
publisher = {Royal Society of Chemistry (RSC)},
month = {jun},
url = {https://xlink.rsc.org/?DOI=C9SC02905B},
number = {32},
pages = {7554--7560},
doi = {10.1039/c9sc02905b}
}
MLA
Cite this
MLA Copy
Gao, Shang, et al. “α-Silicon effect assisted Curtin–Hammett allylation using allylcopper reagents derived from 1,3-dienylsilanes.” Chemical Science, vol. 10, no. 32, Jun. 2019, pp. 7554-7560. https://xlink.rsc.org/?DOI=C9SC02905B.