Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds.
Rolando Cannalire
1
,
Sveva Pelliccia
1, 2, 3, 4, 5
,
Luca Sancineto
6, 7, 8, 9, 10, 11
,
Ettore Novellino
1
,
Gian Cesare Tron
5, 12, 13, 14, 15
,
Mariateresa Giustiniano
1, 2, 3, 4, 5
2
Department of pharmacy
4
Napoli
|
5
ITALY
|
7
Department of Pharmaceutical Sciences
9
Group of Catalysis
10
Synthesis and Organic Green Chemistry
11
06123 Perugia
|
13
Department of Drug's Sciences
15
Novara
|
Publication type: Journal Article
Publication date: 2021-01-01
scimago Q1
wos Q1
SJR: 11.467
CiteScore: 73.2
Impact factor: 39.0
ISSN: 03060012, 14604744
PubMed ID:
33350402
General Chemistry
Abstract
The late stage functionalization (LSF) of complex biorelevant compounds is a powerful tool to speed up the identification of structure-activity relationships (SARs) and to optimize ADME profiles. To this end, visible-light photocatalysis offers unique opportunities to achieve smooth and clean functionalization of drugs by unlocking site-specific reactivities under generally mild reaction conditions. This review offers a critical assessment of current literature, pointing out the recent developments in the field while emphasizing the expected future progress and potential applications. Along with paragraphs discussing the visible-light photocatalytic synthetic protocols so far available for LSF of drugs and drug candidates, useful and readily accessible synoptic tables of such transformations, divided by functional groups, will be provided, thus enabling a useful, fast, and easy reference to them.
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Total citations:
386
Citations from 2025:
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Cannalire R. et al. Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds. // Chemical Society Reviews. 2021. Vol. 50. No. 2. pp. 766-897.
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Cannalire R., Pelliccia S., Sancineto L., Novellino E., Tron G. C., Giustiniano M. Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds. // Chemical Society Reviews. 2021. Vol. 50. No. 2. pp. 766-897.
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TY - JOUR
DO - 10.1039/D0CS00493F
UR - https://xlink.rsc.org/?DOI=D0CS00493F
TI - Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds.
T2 - Chemical Society Reviews
AU - Cannalire, Rolando
AU - Pelliccia, Sveva
AU - Sancineto, Luca
AU - Novellino, Ettore
AU - Tron, Gian Cesare
AU - Giustiniano, Mariateresa
PY - 2021
DA - 2021/01/01
PB - Royal Society of Chemistry (RSC)
SP - 766-897
IS - 2
VL - 50
PMID - 33350402
SN - 0306-0012
SN - 1460-4744
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_Cannalire,
author = {Rolando Cannalire and Sveva Pelliccia and Luca Sancineto and Ettore Novellino and Gian Cesare Tron and Mariateresa Giustiniano},
title = {Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds.},
journal = {Chemical Society Reviews},
year = {2021},
volume = {50},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=D0CS00493F},
number = {2},
pages = {766--897},
doi = {10.1039/D0CS00493F}
}
Cite this
MLA
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Cannalire, Rolando, et al. “Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds..” Chemical Society Reviews, vol. 50, no. 2, Jan. 2021, pp. 766-897. https://xlink.rsc.org/?DOI=D0CS00493F.
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