Journal of Materials Chemistry B, volume 9, issue 33, pages 6586-6599
Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T-1 relaxivity and selective cytotoxicity to cancer cells
Popov Anton L.
1, 2
,
Abakumov Maxim A.
3, 4
,
Savintseva I V
2
,
Ermakov Artem M.
2
,
Popova Nadezhda
2
,
Ivanova O S
1
,
Kolmanovich D.D.
2
,
Publication type: Journal Article
Publication date: 2021-08-04
Journal:
Journal of Materials Chemistry B
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7
ISSN: 20507518, 2050750X
PubMed ID:
34369536
General Chemistry
General Medicine
General Materials Science
Biomedical Engineering
Abstract
Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern are possible gadolinium deposition in the brain and the development of systemic nephrogenic fibrosis after repeated use of MRI contrasts. Thus, there is an urgent need to develop a new generation of MRI contrasts that are safe and that have high selectivity in tissue accumulation with improved local contrast. Here, we report on a new type of theranostic MRI contrast, namely dextran stabilised, gadolinium doped cerium dioxide nanoparticles. These ultra-small (4–6 nm) Ce0.9Gd0.1O1.95 nanoparticles have been shown to possess excellent colloidal stability and high r1-relaxivity (3.6 mM−1 s−1). They are effectively internalised by human normal and cancer cells and demonstrate dose-dependent selective cytotoxicity to cancer cells.
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Popov A. L. et al. Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T-1 relaxivity and selective cytotoxicity to cancer cells // Journal of Materials Chemistry B. 2021. Vol. 9. No. 33. pp. 6586-6599.
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Popov A. L., Abakumov M. A., Savintseva I. V., Ermakov A. M., Popova N., Ivanova O. S., Kolmanovich D., Baranchikov A. E., Ivanov V. K. Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T-1 relaxivity and selective cytotoxicity to cancer cells // Journal of Materials Chemistry B. 2021. Vol. 9. No. 33. pp. 6586-6599.
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TY - JOUR
DO - 10.1039/D1TB01147B
UR - https://doi.org/10.1039%2FD1TB01147B
TI - Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T-1 relaxivity and selective cytotoxicity to cancer cells
T2 - Journal of Materials Chemistry B
AU - Popov, Anton L.
AU - Abakumov, Maxim A.
AU - Baranchikov, Alexander E
AU - Ivanov, Vladimir K.
AU - Kolmanovich, D.D.
AU - Savintseva, I V
AU - Ermakov, Artem M.
AU - Popova, Nadezhda
AU - Ivanova, O S
PY - 2021
DA - 2021/08/04 00:00:00
PB - Royal Society of Chemistry (RSC)
SP - 6586-6599
IS - 33
VL - 9
PMID - 34369536
SN - 2050-7518
SN - 2050-750X
ER -
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@article{2021_Popov,
author = {Anton L. Popov and Maxim A. Abakumov and Alexander E Baranchikov and Vladimir K. Ivanov and D.D. Kolmanovich and I V Savintseva and Artem M. Ermakov and Nadezhda Popova and O S Ivanova},
title = {Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T-1 relaxivity and selective cytotoxicity to cancer cells},
journal = {Journal of Materials Chemistry B},
year = {2021},
volume = {9},
publisher = {Royal Society of Chemistry (RSC)},
month = {aug},
url = {https://doi.org/10.1039%2FD1TB01147B},
number = {33},
pages = {6586--6599},
doi = {10.1039/D1TB01147B}
}
Cite this
MLA
Copy
Popov, Anton L., et al. “Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T-1 relaxivity and selective cytotoxicity to cancer cells.” Journal of Materials Chemistry B, vol. 9, no. 33, Aug. 2021, pp. 6586-6599. https://doi.org/10.1039%2FD1TB01147B.