Bioorthogonal chemistry for prodrug activation in vivo
Тип публикации: Journal Article
Дата публикации: 2023-10-31
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 11.348
CiteScore: 70.7
Impact factor: 48.3
ISSN: 03060012, 14604744
PubMed ID:
37905601
General Chemistry
Краткое описание
Prodrugs have emerged as a major strategy for addressing clinical challenges by improving drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence of new bioorthogonal chemistry has greatly facilitated the development of prodrug strategies, enabling their activation through chemical and physical stimuli. This “on-demand” activation using bioorthogonal chemistry has revolutionized the research and development of prodrugs. Consequently, prodrug activation has garnered significant attention and emerged as an exciting field of translational research. This review summarizes the latest advancements in prodrug activation by utilizing bioorthogonal chemistry and mainly focuses on the activation of small-molecule prodrugs and antibody–drug conjugates. In addition, this review also discusses the opportunities and challenges of translating these advancements into clinical practice.
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156
Всего цитирований:
156
Цитирований c 2025:
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(80.13%)
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ГОСТ |
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MLA
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ГОСТ
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Fu Q. et al. Bioorthogonal chemistry for prodrug activation in vivo // Chemical Society Reviews. 2023. Vol. 52. No. 22. pp. 7737-7772.
ГОСТ со всеми авторами (до 50)
Скопировать
Fu Q., Shen S., Sun P., Gu Z., Bai Y., Wang X., Liu Z. Bioorthogonal chemistry for prodrug activation in vivo // Chemical Society Reviews. 2023. Vol. 52. No. 22. pp. 7737-7772.
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RIS
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TY - JOUR
DO - 10.1039/d2cs00889k
UR - https://xlink.rsc.org/?DOI=D2CS00889K
TI - Bioorthogonal chemistry for prodrug activation in vivo
T2 - Chemical Society Reviews
AU - Fu, Qunfeng
AU - Shen, Siyong
AU - Sun, Pengwei
AU - Gu, Zhi
AU - Bai, Yifei
AU - Wang, Xianglin
AU - Liu, Zhibo
PY - 2023
DA - 2023/10/31
PB - Royal Society of Chemistry (RSC)
SP - 7737-7772
IS - 22
VL - 52
PMID - 37905601
SN - 0306-0012
SN - 1460-4744
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2023_Fu,
author = {Qunfeng Fu and Siyong Shen and Pengwei Sun and Zhi Gu and Yifei Bai and Xianglin Wang and Zhibo Liu},
title = {Bioorthogonal chemistry for prodrug activation in vivo},
journal = {Chemical Society Reviews},
year = {2023},
volume = {52},
publisher = {Royal Society of Chemistry (RSC)},
month = {oct},
url = {https://xlink.rsc.org/?DOI=D2CS00889K},
number = {22},
pages = {7737--7772},
doi = {10.1039/d2cs00889k}
}
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MLA
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Fu, Qunfeng, et al. “Bioorthogonal chemistry for prodrug activation in vivo.” Chemical Society Reviews, vol. 52, no. 22, Oct. 2023, pp. 7737-7772. https://xlink.rsc.org/?DOI=D2CS00889K.
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