Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a new antitumor agent and total synthesis of (S)-espicufolin
Publication type: Journal Article
Publication date: 2007-03-14
scimago Q2
wos Q2
SJR: 0.600
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
DOI:
10.1039/b700838d
PubMed ID:
17406717
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
Two high-yielding strategies for the synthesis of 4H-anthra[1,2-b]pyran antibiotics have been developed giving access to novel antitumor agent (ED(50) 1.5 microm) and to (S)-espicufolin (3). A key step for the assembly of the tetracyclic 4H-anthra[1,2-b]pyran-4,7,12-trione skeleton is the nucleophilic addition of an aryl lithium species onto an aldehyde which allows the introduction of either an ynone or 1,3-diketo side chain, serving as precursors for an acid-catalysed cyclisation.
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Metrics
41
Total citations:
41
Citations from 2024:
4
(9.76%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Tietze L. et al. Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a new antitumor agent and total synthesis of (S)-espicufolin // Organic and Biomolecular Chemistry. 2007. Vol. 5. No. 8. p. 1191.
GOST all authors (up to 50)
Copy
Tietze L., Gericke K. M., Singidi R. R., Schuberth I. Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a new antitumor agent and total synthesis of (S)-espicufolin // Organic and Biomolecular Chemistry. 2007. Vol. 5. No. 8. p. 1191.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/b700838d
UR - https://doi.org/10.1039/b700838d
TI - Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a new antitumor agent and total synthesis of (S)-espicufolin
T2 - Organic and Biomolecular Chemistry
AU - Tietze, L.
AU - Gericke, Kersten M
AU - Singidi, Ramakrishna Reddy
AU - Schuberth, Ingrid
PY - 2007
DA - 2007/03/14
PB - Royal Society of Chemistry (RSC)
SP - 1191
IS - 8
VL - 5
PMID - 17406717
SN - 1477-0520
SN - 1477-0539
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2007_Tietze,
author = {L. Tietze and Kersten M Gericke and Ramakrishna Reddy Singidi and Ingrid Schuberth},
title = {Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a new antitumor agent and total synthesis of (S)-espicufolin},
journal = {Organic and Biomolecular Chemistry},
year = {2007},
volume = {5},
publisher = {Royal Society of Chemistry (RSC)},
month = {mar},
url = {https://doi.org/10.1039/b700838d},
number = {8},
pages = {1191},
doi = {10.1039/b700838d}
}
Cite this
MLA
Copy
Tietze, L., et al. “Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a new antitumor agent and total synthesis of (S)-espicufolin.” Organic and Biomolecular Chemistry, vol. 5, no. 8, Mar. 2007, p. 1191. https://doi.org/10.1039/b700838d.