Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties
Saleta Vazquez-Rodriguez
1
,
Roberto Figueroa Guíñez
2
,
Roberto Figueroa-Guíñez
2
,
Maria J Matos
1
,
Lourdes SANTANA
1
,
Eugenio Uriarte
1
,
Michel Lapier
2
,
JUAN MAYA
3
,
Claudio Olea-Azar
2
Publication type: Journal Article
Publication date: 2013-04-23
SJR: —
CiteScore: —
Impact factor: —
ISSN: 20402503, 20402511
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Pharmaceutical Science
Molecular Medicine
Abstract
Based on the observed biological activities of coumarins and chalcones, we have synthesized coumarin–chalcone hybrids with the aim of evaluating their antioxidant properties and trypanocidal activity against Trypanosoma cruzi, the parasite responsible for Chagas disease. All derivatives have been proved to be good antioxidants in spite of their moderate trypanocidal activity in the epimastigote stage (clone Dm28c). Based on these results, we can conclude that compounds 4 and 5 are potential candidates for in vitro studies of their antioxidant activity. These preliminary findings encourage us to the future structural optimization of these kinds of compounds.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
7
|
|
|
RSC Advances
7 publications, 10.14%
|
|
|
Molecules
5 publications, 7.25%
|
|
|
Arabian Journal of Chemistry
4 publications, 5.8%
|
|
|
Journal of Organic Chemistry
4 publications, 5.8%
|
|
|
Journal of Molecular Structure
3 publications, 4.35%
|
|
|
Bioorganic and Medicinal Chemistry
3 publications, 4.35%
|
|
|
Current Organic Chemistry
2 publications, 2.9%
|
|
|
Tetrahedron Letters
2 publications, 2.9%
|
|
|
Chemical Biology and Drug Design
2 publications, 2.9%
|
|
|
Asian Journal of Organic Chemistry
2 publications, 2.9%
|
|
|
Letters in Drug Design and Discovery
1 publication, 1.45%
|
|
|
Letters in Organic Chemistry
1 publication, 1.45%
|
|
|
Journal of the Iranian Chemical Society
1 publication, 1.45%
|
|
|
Russian Chemical Bulletin
1 publication, 1.45%
|
|
|
Molecular Biology Reports
1 publication, 1.45%
|
|
|
Heliyon
1 publication, 1.45%
|
|
|
Saudi Journal of Biological Sciences
1 publication, 1.45%
|
|
|
IOP Conference Series: Earth and Environmental Science
1 publication, 1.45%
|
|
|
PLoS ONE
1 publication, 1.45%
|
|
|
Inorganica Chimica Acta
1 publication, 1.45%
|
|
|
Computational and Theoretical Chemistry
1 publication, 1.45%
|
|
|
Journal of Inorganic Biochemistry
1 publication, 1.45%
|
|
|
Bioorganic Chemistry
1 publication, 1.45%
|
|
|
European Journal of Medicinal Chemistry
1 publication, 1.45%
|
|
|
Chemical Record
1 publication, 1.45%
|
|
|
ACS Sustainable Chemistry and Engineering
1 publication, 1.45%
|
|
|
Journal of Chemical Information and Modeling
1 publication, 1.45%
|
|
|
Journal of Physical Chemistry A
1 publication, 1.45%
|
|
|
ChemistrySelect
1 publication, 1.45%
|
|
|
New Journal of Chemistry
1 publication, 1.45%
|
|
|
1
2
3
4
5
6
7
|
Publishers
|
2
4
6
8
10
12
14
16
18
|
|
|
Elsevier
17 publications, 24.64%
|
|
|
American Chemical Society (ACS)
8 publications, 11.59%
|
|
|
Royal Society of Chemistry (RSC)
8 publications, 11.59%
|
|
|
Wiley
7 publications, 10.14%
|
|
|
MDPI
5 publications, 7.25%
|
|
|
King Saud University
5 publications, 7.25%
|
|
|
Bentham Science Publishers Ltd.
4 publications, 5.8%
|
|
|
Springer Nature
4 publications, 5.8%
|
|
|
Taylor & Francis
3 publications, 4.35%
|
|
|
IOP Publishing
1 publication, 1.45%
|
|
|
Public Library of Science (PLoS)
1 publication, 1.45%
|
|
|
Academic Journals
1 publication, 1.45%
|
|
|
Asian Journal of Chemistry
1 publication, 1.45%
|
|
|
European Journal of Chemistry
1 publication, 1.45%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 1.45%
|
|
|
American Society for Microbiology
1 publication, 1.45%
|
|
|
Pleiades Publishing
1 publication, 1.45%
|
|
|
2
4
6
8
10
12
14
16
18
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
69
Total citations:
69
Citations from 2025:
4
(5.8%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Vazquez-Rodriguez S. et al. Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties // MedChemComm. 2013. Vol. 4. No. 6. p. 993.
GOST all authors (up to 50)
Copy
Vazquez-Rodriguez S., Figueroa Guíñez R., Figueroa-Guíñez R., Matos M. J., SANTANA L., Uriarte E., Lapier M., MAYA J., Olea-Azar C. Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties // MedChemComm. 2013. Vol. 4. No. 6. p. 993.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c3md00025g
UR - https://doi.org/10.1039/c3md00025g
TI - Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties
T2 - MedChemComm
AU - Vazquez-Rodriguez, Saleta
AU - Figueroa Guíñez, Roberto
AU - Figueroa-Guíñez, Roberto
AU - Matos, Maria J
AU - SANTANA, Lourdes
AU - Uriarte, Eugenio
AU - Lapier, Michel
AU - MAYA, JUAN
AU - Olea-Azar, Claudio
PY - 2013
DA - 2013/04/23
PB - Royal Society of Chemistry (RSC)
SP - 993
IS - 6
VL - 4
SN - 2040-2503
SN - 2040-2511
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2013_Vazquez-Rodriguez,
author = {Saleta Vazquez-Rodriguez and Roberto Figueroa Guíñez and Roberto Figueroa-Guíñez and Maria J Matos and Lourdes SANTANA and Eugenio Uriarte and Michel Lapier and JUAN MAYA and Claudio Olea-Azar},
title = {Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties},
journal = {MedChemComm},
year = {2013},
volume = {4},
publisher = {Royal Society of Chemistry (RSC)},
month = {apr},
url = {https://doi.org/10.1039/c3md00025g},
number = {6},
pages = {993},
doi = {10.1039/c3md00025g}
}
Cite this
MLA
Copy
Vazquez-Rodriguez, Saleta, et al. “Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties.” MedChemComm, vol. 4, no. 6, Apr. 2013, p. 993. https://doi.org/10.1039/c3md00025g.