Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties
Saleta Vazquez-Rodriguez
1
,
Roberto Figueroa Guíñez
2
,
Roberto Figueroa-Guíñez
2
,
Maria J Matos
1
,
Lourdes SANTANA
1
,
Eugenio Uriarte
1
,
Michel Lapier
2
,
JUAN MAYA
3
,
Claudio Olea-Azar
2
Тип публикации: Journal Article
Дата публикации: 2013-04-23
SJR: —
CiteScore: —
Impact factor: —
ISSN: 20402503, 20402511
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Pharmaceutical Science
Molecular Medicine
Краткое описание
Based on the observed biological activities of coumarins and chalcones, we have synthesized coumarin–chalcone hybrids with the aim of evaluating their antioxidant properties and trypanocidal activity against Trypanosoma cruzi, the parasite responsible for Chagas disease. All derivatives have been proved to be good antioxidants in spite of their moderate trypanocidal activity in the epimastigote stage (clone Dm28c). Based on these results, we can conclude that compounds 4 and 5 are potential candidates for in vitro studies of their antioxidant activity. These preliminary findings encourage us to the future structural optimization of these kinds of compounds.
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69
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MLA
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ГОСТ
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Vazquez-Rodriguez S. et al. Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties // MedChemComm. 2013. Vol. 4. No. 6. p. 993.
ГОСТ со всеми авторами (до 50)
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Vazquez-Rodriguez S., Figueroa Guíñez R., Figueroa-Guíñez R., Matos M. J., SANTANA L., Uriarte E., Lapier M., MAYA J., Olea-Azar C. Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties // MedChemComm. 2013. Vol. 4. No. 6. p. 993.
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RIS
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TY - JOUR
DO - 10.1039/c3md00025g
UR - https://doi.org/10.1039/c3md00025g
TI - Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties
T2 - MedChemComm
AU - Vazquez-Rodriguez, Saleta
AU - Figueroa Guíñez, Roberto
AU - Figueroa-Guíñez, Roberto
AU - Matos, Maria J
AU - SANTANA, Lourdes
AU - Uriarte, Eugenio
AU - Lapier, Michel
AU - MAYA, JUAN
AU - Olea-Azar, Claudio
PY - 2013
DA - 2013/04/23
PB - Royal Society of Chemistry (RSC)
SP - 993
IS - 6
VL - 4
SN - 2040-2503
SN - 2040-2511
ER -
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BibTex (до 50 авторов)
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@article{2013_Vazquez-Rodriguez,
author = {Saleta Vazquez-Rodriguez and Roberto Figueroa Guíñez and Roberto Figueroa-Guíñez and Maria J Matos and Lourdes SANTANA and Eugenio Uriarte and Michel Lapier and JUAN MAYA and Claudio Olea-Azar},
title = {Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties},
journal = {MedChemComm},
year = {2013},
volume = {4},
publisher = {Royal Society of Chemistry (RSC)},
month = {apr},
url = {https://doi.org/10.1039/c3md00025g},
number = {6},
pages = {993},
doi = {10.1039/c3md00025g}
}
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MLA
Скопировать
Vazquez-Rodriguez, Saleta, et al. “Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties.” MedChemComm, vol. 4, no. 6, Apr. 2013, p. 993. https://doi.org/10.1039/c3md00025g.