Organic and Biomolecular Chemistry

, volume 14 , issue 45 , pages 10593-10598

Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach.

Leonid V. Romashov ¹

Valentine P. Ananikov ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991 Moscow, Russia |

Saint Petersburg State University, Stary Petergof, Saint Petersburg, Russia |

Publication type: Journal Article

Publication date: 2016-09-30

Royal Society of Chemistry (RSC)

Organic and Biomolecular Chemistry

scimago Q2

wos Q2

SJR: 0.600

CiteScore: 5.2

Impact factor: 2.7

ISSN: 14770520, 14770539

DOI: 10.1039/c6ob01731b

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PubMed ID: 27714265

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

A biomass-derived platform chemical was utilized to access a demanded pharmaceutical substance with anti-HIV activity (HIV, human immunodeficiency virus) and a variety of structural analogues. Step economy in the synthesis of the drug core (single stage from cellulose) is studied including flexible variability of four structural units. The first synthesis and X-ray structure of the inhibitor of HIV-1 capsid protein assembly (CAP-1) is described.

Found

4 citations

Burmistrov Vladimir

🥼 🤝

DSc in Chemistry, associate professor

86 publications, 606 citations

h-index: 13

Volgograd State Technical University

Research interests

Analytical Chemistry

Biochemistry

Gas chromatography (GS)

3 citations

Galkin Konstantin

🥼 🤝

PhD in Chemistry, associate professor

30 publications, 1 314 citations, 4 reviews

h-index: 16

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Moscow Institute of Physics and Technology

Moscow Polytechnic University

3 citations

Vernigora Andrey

🤝

27 publications, 127 citations

h-index: 7

Volgograd State Technical University

Research interests

Medicinal Chemistry

1 citation

Karlinskii Bogdan

PhD in Chemistry

16 publications, 223 citations, 78 reviews

h-index: 8

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Tula State University

1 citation

Makarov Vadim

🥼 🤝

DSc in Chemistry

177 publications, 4 604 citations, 5 reviews

h-index: 36

Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences

Research interests

Early drug discovery

Medicinal Chemistry

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Romashov L. V., Ananikov V. P. Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach. // Organic and Biomolecular Chemistry. 2016. Vol. 14. No. 45. pp. 10593-10598.

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RIS Copy

TY - JOUR

DO - 10.1039/c6ob01731b

UR - https://xlink.rsc.org/?DOI=C6OB01731B

TI - Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach.

T2 - Organic and Biomolecular Chemistry

AU - Romashov, Leonid V.

AU - Ananikov, Valentine P.

PY - 2016

DA - 2016/09/30

PB - Royal Society of Chemistry (RSC)

SP - 10593-10598

IS - 45

VL - 14

PMID - 27714265

SN - 1477-0520

SN - 1477-0539

ER -

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@article{2016_Romashov,

author = {Leonid V. Romashov and Valentine P. Ananikov},

title = {Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach.},

journal = {Organic and Biomolecular Chemistry},

year = {2016},

volume = {14},

publisher = {Royal Society of Chemistry (RSC)},

month = {sep},

url = {https://xlink.rsc.org/?DOI=C6OB01731B},

number = {45},

pages = {10593--10598},

doi = {10.1039/c6ob01731b}

}

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Romashov, Leonid V., et al. “Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach..” Organic and Biomolecular Chemistry, vol. 14, no. 45, Sep. 2016, pp. 10593-10598. https://xlink.rsc.org/?DOI=C6OB01731B.