Catalytic alkylation of unactivated C(sp3)–H bonds for C(sp3)–C(sp3) bond formation
Zhen Chen
1, 2, 3, 4, 5, 6
,
Meng Yu Rong
1
,
Meng-Yu Rong
1, 2, 3, 4, 5, 6
,
Jing Nie
1, 2, 3, 4, 5, 6
,
Xue-Feng Zhu
7, 8, 9, 10
,
Bingfeng Shi
2, 6, 11, 12, 13
,
Junan Ma
1, 2, 3, 4, 5, 6
2
DEPARTMENT OF CHEMISTRY
3
Tianjin Key Laboratory of Molecular Optoelectronic Sciences
|
4
5
Tianjin 300072
|
6
P. R. China
|
7
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California, 92121, USA
|
8
Genomics Institute of the Novartis Research Foundation
9
San Diego
|
10
Usa
|
13
Hangzhou 310027
|
Publication type: Journal Article
Publication date: 2019-08-12
scimago Q1
wos Q1
SJR: 11.467
CiteScore: 73.2
Impact factor: 39.0
ISSN: 03060012, 14604744
PubMed ID:
31403147
General Chemistry
Abstract
The construction of carbon–carbon bonds is a central tenet of modern synthetic chemistry. Metal-catalyzed C–H functionalization can serve as a particularly powerful tool for achieving carbon–carbon bond formation. This review summarizes the early adventures and recent advancements in catalytic transformation of unactivated C(sp3)–H bonds into C(sp3)–C(sp3) bonds. To date, three main strategies have emerged to enable this transformation, namely, metallocarbene-triggered C(sp3)–H alkylation, auxiliary-directed C(sp3)–H alkylation, and photo-induced C(sp3)–H alkylation. Compared with traditional cross-coupling reactions having both coupling partners activated with functional groups or base-promoted enolate chemistry, catalytic alkylation of unactivated C(sp3)–H bonds for C(sp3)–C(sp3) bond formation not only offers novel disconnections in retrosynthetic analysis, but also represents the future trend in green and atom-economic chemistry.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
5
10
15
20
25
30
35
40
|
|
|
Organic Letters
39 publications, 13.88%
|
|
|
Organic Chemistry Frontiers
20 publications, 7.12%
|
|
|
Advanced Synthesis and Catalysis
15 publications, 5.34%
|
|
|
Angewandte Chemie
15 publications, 5.34%
|
|
|
Angewandte Chemie - International Edition
15 publications, 5.34%
|
|
|
ACS Catalysis
14 publications, 4.98%
|
|
|
Journal of Organic Chemistry
12 publications, 4.27%
|
|
|
Organic and Biomolecular Chemistry
12 publications, 4.27%
|
|
|
Chemical Communications
11 publications, 3.91%
|
|
|
Journal of the American Chemical Society
8 publications, 2.85%
|
|
|
Chemical Society Reviews
7 publications, 2.49%
|
|
|
Chinese Journal of Organic Chemistry
6 publications, 2.14%
|
|
|
Asian Journal of Organic Chemistry
6 publications, 2.14%
|
|
|
Tetrahedron Letters
5 publications, 1.78%
|
|
|
Chemical Reviews
4 publications, 1.42%
|
|
|
Tetrahedron
4 publications, 1.42%
|
|
|
Chemistry - A European Journal
4 publications, 1.42%
|
|
|
European Journal of Organic Chemistry
4 publications, 1.42%
|
|
|
Green Chemistry
4 publications, 1.42%
|
|
|
Chemical Science
4 publications, 1.42%
|
|
|
Science China Chemistry
3 publications, 1.07%
|
|
|
Coordination Chemistry Reviews
3 publications, 1.07%
|
|
|
Chem
3 publications, 1.07%
|
|
|
Journal of Catalysis
3 publications, 1.07%
|
|
|
Chinese Journal of Chemistry
3 publications, 1.07%
|
|
|
ACS Organic & Inorganic Au
3 publications, 1.07%
|
|
|
Nature Communications
2 publications, 0.71%
|
|
|
ChemistrySelect
2 publications, 0.71%
|
|
|
Synlett
2 publications, 0.71%
|
|
|
5
10
15
20
25
30
35
40
|
Publishers
|
10
20
30
40
50
60
70
80
90
|
|
|
American Chemical Society (ACS)
88 publications, 31.32%
|
|
|
Wiley
75 publications, 26.69%
|
|
|
Royal Society of Chemistry (RSC)
61 publications, 21.71%
|
|
|
Elsevier
27 publications, 9.61%
|
|
|
Springer Nature
8 publications, 2.85%
|
|
|
Shanghai Institute of Organic Chemistry
6 publications, 2.14%
|
|
|
Georg Thieme Verlag KG
4 publications, 1.42%
|
|
|
MDPI
3 publications, 1.07%
|
|
|
Taylor & Francis
2 publications, 0.71%
|
|
|
Beilstein-Institut
1 publication, 0.36%
|
|
|
Oxford University Press
1 publication, 0.36%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 0.36%
|
|
|
King Saud University
1 publication, 0.36%
|
|
|
Research Square Platform LLC
1 publication, 0.36%
|
|
|
American Association for the Advancement of Science (AAAS)
1 publication, 0.36%
|
|
|
Tsinghua University Press
1 publication, 0.36%
|
|
|
10
20
30
40
50
60
70
80
90
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
281
Total citations:
281
Citations from 2025:
49
(17.44%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Chen Z. et al. Catalytic alkylation of unactivated C(sp3)–H bonds for C(sp3)–C(sp3) bond formation // Chemical Society Reviews. 2019. Vol. 48. No. 18. pp. 4921-4942.
GOST all authors (up to 50)
Copy
Chen Z., Rong M. Yu., Rong M., Nie J., Zhu X., Shi B., Ma J. Catalytic alkylation of unactivated C(sp3)–H bonds for C(sp3)–C(sp3) bond formation // Chemical Society Reviews. 2019. Vol. 48. No. 18. pp. 4921-4942.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c9cs00086k
UR - https://xlink.rsc.org/?DOI=C9CS00086K
TI - Catalytic alkylation of unactivated C(sp3)–H bonds for C(sp3)–C(sp3) bond formation
T2 - Chemical Society Reviews
AU - Chen, Zhen
AU - Rong, Meng Yu
AU - Rong, Meng-Yu
AU - Nie, Jing
AU - Zhu, Xue-Feng
AU - Shi, Bingfeng
AU - Ma, Junan
PY - 2019
DA - 2019/08/12
PB - Royal Society of Chemistry (RSC)
SP - 4921-4942
IS - 18
VL - 48
PMID - 31403147
SN - 0306-0012
SN - 1460-4744
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Chen,
author = {Zhen Chen and Meng Yu Rong and Meng-Yu Rong and Jing Nie and Xue-Feng Zhu and Bingfeng Shi and Junan Ma},
title = {Catalytic alkylation of unactivated C(sp3)–H bonds for C(sp3)–C(sp3) bond formation},
journal = {Chemical Society Reviews},
year = {2019},
volume = {48},
publisher = {Royal Society of Chemistry (RSC)},
month = {aug},
url = {https://xlink.rsc.org/?DOI=C9CS00086K},
number = {18},
pages = {4921--4942},
doi = {10.1039/c9cs00086k}
}
Cite this
MLA
Copy
Chen, Zhen, et al. “Catalytic alkylation of unactivated C(sp3)–H bonds for C(sp3)–C(sp3) bond formation.” Chemical Society Reviews, vol. 48, no. 18, Aug. 2019, pp. 4921-4942. https://xlink.rsc.org/?DOI=C9CS00086K.