Open Access
Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis
Anastasia I. Shpichka
1, 2, 3, 4, 5
,
Petr V. Konarev
6, 7
,
P.V. Konarev
4, 5, 8, 9, 10
,
Yuri M. Efremov
1, 2, 3, 4, 5
,
A E Kryukova
4, 5, 6, 7, 8, 9, 10
,
N A Aksenova
1, 11
,
Svetlana L Kotova
1, 11
,
S.L. Kotova
2, 3, 4, 5, 12
,
A A Frolova
2, 3, 4, 5
,
Nastasia V. Kosheleva
13, 14
,
N V Kosheleva
4, 5, 15, 16, 17
,
O. M. Zhigalina
4, 5, 6, 8, 9, 18, 19
,
V. I. Yusupov
4, 5, 9, 20
,
Dmitry Khmelenin
6
,
D N Khmelenin
4, 5, 8, 9
,
Anastasia Koroleva
21
,
A Koroleva
22, 23, 24
,
V. S. Volkov
4, 5, 6, 8, 9
,
V. E. Asadchikov
4, 5, 6, 8, 9
,
Petr S. Timashev
1, 2, 3, 4, 5, 11, 12, 25
2
Institute for Regenerative Medicine
4
Moscow
5
Russia
|
6
11
12
Department of Polymers and Composites
16
Faculty of Biology
21
Laser Zentrum Hannover e. V., Hannover, Germany
|
22
Laser Zentrum Hannover e. V.
23
HANNOVER
24
GERMANY
|
Publication type: Journal Article
Publication date: 2020-01-24
scimago Q1
wos Q2
SJR: 0.777
CiteScore: 7.6
Impact factor: 4.6
ISSN: 20462069
PubMed ID:
35495227
General Chemistry
General Chemical Engineering
Abstract
Fibrin is a well-known tool in tissue engineering, but the structure of its modifications created to improve its properties remains undiscussed despite its importance, e.g. in designing biomaterials that ensure cell migration and lumenogenesis. We sought to uncover the structural aspects of PEGylated fibrin hydrogels shown to contribute to angiogenesis. The analysis of the small-angle X-ray scattering (SAXS) data and ab initio modeling revealed that the PEGylation of fibrinogen led to the formation of oligomeric species, which are larger at a higher PEG : fibrinogen molar ratio. The improvement of optical properties was provided by the decrease in aggregates' sizes and also by retaining the bound water. Compared to the native fibrin, the structure of the 5 : 1 PEGylated fibrin gel consisted of homogenously distributed flexible fibrils with a smaller space between them. Moreover, as arginylglycylaspartic acid (RGD) sites may be partly bound to PEG-NHS or masked because of the oligomerization, the number of adhesion sites may be slightly reduced that may provide the better cell migration and formation of continuous capillary-like structures.
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Metrics
28
Total citations:
28
Citations from 2024:
4
(14.28%)
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GOST
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Shpichka A. I. et al. Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis // RSC Advances. 2020. Vol. 10. No. 8. pp. 4190-4200.
GOST all authors (up to 50)
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Shpichka A. I. et al. Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis // RSC Advances. 2020. Vol. 10. No. 8. pp. 4190-4200.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c9ra08169k
UR - https://xlink.rsc.org/?DOI=C9RA08169K
TI - Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis
T2 - RSC Advances
AU - Shpichka, Anastasia I.
AU - Konarev, Petr V.
AU - Konarev, P.V.
AU - Efremov, Yuri M.
AU - Kryukova, A E
AU - Aksenova, N A
AU - Kotova, Svetlana L
AU - Kotova, S.L.
AU - Frolova, Anastasia A
AU - Frolova, A A
AU - Kosheleva, Nastasia V.
AU - Kosheleva, N V
AU - Zhigalina, O. M.
AU - Yusupov, V. I.
AU - Khmelenin, Dmitry
AU - Khmelenin, D N
AU - Koroleva, Anastasia
AU - Koroleva, A
AU - Volkov, V. S.
AU - Asadchikov, V. E.
AU - Timashev, Petr S.
PY - 2020
DA - 2020/01/24
PB - Royal Society of Chemistry (RSC)
SP - 4190-4200
IS - 8
VL - 10
PMID - 35495227
SN - 2046-2069
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Shpichka,
author = {Anastasia I. Shpichka and Petr V. Konarev and P.V. Konarev and Yuri M. Efremov and A E Kryukova and N A Aksenova and Svetlana L Kotova and S.L. Kotova and Anastasia A Frolova and A A Frolova and Nastasia V. Kosheleva and N V Kosheleva and O. M. Zhigalina and V. I. Yusupov and Dmitry Khmelenin and D N Khmelenin and Anastasia Koroleva and A Koroleva and V. S. Volkov and V. E. Asadchikov and Petr S. Timashev and others},
title = {Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis},
journal = {RSC Advances},
year = {2020},
volume = {10},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=C9RA08169K},
number = {8},
pages = {4190--4200},
doi = {10.1039/c9ra08169k}
}
Cite this
MLA
Copy
Shpichka, Anastasia I., et al. “Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis.” RSC Advances, vol. 10, no. 8, Jan. 2020, pp. 4190-4200. https://xlink.rsc.org/?DOI=C9RA08169K.