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RSC Advances

, том 10 , издание 8 , страницы 4190-4200

Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis

Anastasia I. Shpichka ^{1, 2, 3, 4, 5}

Petr V. Konarev ^{6, 7}

P.V. Konarev ^{4, 5, 8, 9, 10}

Yuri M. Efremov ^{1, 2, 3, 4, 5}

A E Kryukova ^{4, 5, 6, 7, 8, 9, 10}

N A Aksenova ^{1, 11}

Svetlana L Kotova ^{1, 11}

S.L. Kotova ^{2, 3, 4, 5, 12}

Anastasia A Frolova ¹

A A Frolova ^{2, 3, 4, 5}

Nastasia V. Kosheleva ^{13, 14}

N V Kosheleva ^{4, 5, 15, 16, 17}

O. M. Zhigalina ^{4, 5, 6, 8, 9, 18, 19}

V. I. Yusupov ^{4, 5, 9, 20}

Dmitry Khmelenin ⁶

D N Khmelenin ^{4, 5, 8, 9}

Anastasia Koroleva ²¹

A Koroleva ^{22, 23, 24}

V. S. Volkov ^{4, 5, 6, 8, 9}

V. E. Asadchikov ^{4, 5, 6, 8, 9}

Petr S. Timashev ^{1, 2, 3, 4, 5, 11, 12, 25}

Скрыть аффилиации авторов Показать аффилиации авторов: 25 аффилиаций

Institute for Regenerative Medicine, Sechenov University, 2-8 Trubetskaya St., Moscow, Russia |

Institute for Regenerative Medicine

Sechenov University |

⁴

Moscow

⁵

Russia |

⁶

A. V. Shubnikov Institute of Crystallography, Federal Scientific Research Center “Crystallography and Photonics” RAS, Moscow, Russia

Курчатовский комплекс "Кристаллография и Фотоника"

Институт кристаллографии имени А. В. Шубникова

⁷

National research center “Kurchatov Institute”, Moscow, Russia |

⁸

A. V. Shubnikov Institute of Crystallography |

⁹

Federal Scientific Research Center “Crystallography and Photonics” RAS |

¹⁰

National Research Center “Kurchatov Institute” |

¹¹

Department of Polymers and Composites, N. N. Semenov Institute of Chemical Physics, Moscow, Russia |

¹²

Department of Polymers and Composites

¹³

FSBSI ‘Institute of General Pathology and Pathophysiology’, Moscow, Russia |

¹⁴

Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia |

¹⁵

FSBSI ‘Institute of General Pathology and Pathophysiology’ |

¹⁶

Faculty of Biology

¹⁷

Lomonosov Moscow State University |

¹⁸

Bauman Moscow State Technical University, Moscow, Russia |

¹⁹

Bauman Moscow State Technical University |

²⁰

Institute of Photon Technologies |

²¹

Laser Zentrum Hannover e. V., Hannover, Germany |

²²

Laser Zentrum Hannover e. V.

²³

HANNOVER

²⁴

GERMANY |

²⁵

Institute of Photon Technologies, Federal Scientific Research Center “Crystallography and Photonics” RAS, Moscow, Russia

Курчатовский комплекс "Кристаллография и Фотоника"

Институт фотонных технологий

Тип публикации: Journal Article

Дата публикации: 2020-01-24

Royal Society of Chemistry (RSC)

RSC Advances

scimago Q1

wos Q2

БС1

SJR: 0.777

CiteScore: 7.6

Impact factor: 4.6

ISSN: 20462069

DOI: 10.1039/c9ra08169k

Скопировать DOI

PubMed ID: 35495227

General Chemistry

General Chemical Engineering

Краткое описание

Fibrin is a well-known tool in tissue engineering, but the structure of its modifications created to improve its properties remains undiscussed despite its importance, e.g. in designing biomaterials that ensure cell migration and lumenogenesis. We sought to uncover the structural aspects of PEGylated fibrin hydrogels shown to contribute to angiogenesis. The analysis of the small-angle X-ray scattering (SAXS) data and ab initio modeling revealed that the PEGylation of fibrinogen led to the formation of oligomeric species, which are larger at a higher PEG : fibrinogen molar ratio. The improvement of optical properties was provided by the decrease in aggregates' sizes and also by retaining the bound water. Compared to the native fibrin, the structure of the 5 : 1 PEGylated fibrin gel consisted of homogenously distributed flexible fibrils with a smaller space between them. Moreover, as arginylglycylaspartic acid (RGD) sites may be partly bound to PEG-NHS or masked because of the oligomerization, the number of adhesion sites may be slightly reduced that may provide the better cell migration and formation of continuous capillary-like structures.

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Shpichka A. I. et al. Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis // RSC Advances. 2020. Vol. 10. No. 8. pp. 4190-4200.

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Shpichka A. I. et al. Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis // RSC Advances. 2020. Vol. 10. No. 8. pp. 4190-4200.

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TY - JOUR

DO - 10.1039/c9ra08169k

UR - https://xlink.rsc.org/?DOI=C9RA08169K

TI - Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis

T2 - RSC Advances

AU - Shpichka, Anastasia I.

AU - Konarev, Petr V.

AU - Konarev, P.V.

AU - Efremov, Yuri M.

AU - Kryukova, A E

AU - Aksenova, N A

AU - Kotova, Svetlana L

AU - Kotova, S.L.

AU - Frolova, Anastasia A

AU - Frolova, A A

AU - Kosheleva, Nastasia V.

AU - Kosheleva, N V

AU - Zhigalina, O. M.

AU - Yusupov, V. I.

AU - Khmelenin, Dmitry

AU - Khmelenin, D N

AU - Koroleva, Anastasia

AU - Koroleva, A

AU - Volkov, V. S.

AU - Asadchikov, V. E.

AU - Timashev, Petr S.

PY - 2020

DA - 2020/01/24

PB - Royal Society of Chemistry (RSC)

SP - 4190-4200

IS - 8

VL - 10

PMID - 35495227

SN - 2046-2069

ER -

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@article{2020_Shpichka,

author = {Anastasia I. Shpichka and Petr V. Konarev and P.V. Konarev and Yuri M. Efremov and A E Kryukova and N A Aksenova and Svetlana L Kotova and S.L. Kotova and Anastasia A Frolova and A A Frolova and Nastasia V. Kosheleva and N V Kosheleva and O. M. Zhigalina and V. I. Yusupov and Dmitry Khmelenin and D N Khmelenin and Anastasia Koroleva and A Koroleva and V. S. Volkov and V. E. Asadchikov and Petr S. Timashev and others},

title = {Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis},

journal = {RSC Advances},

year = {2020},

volume = {10},

publisher = {Royal Society of Chemistry (RSC)},

month = {jan},

url = {https://xlink.rsc.org/?DOI=C9RA08169K},

number = {8},

pages = {4190--4200},

doi = {10.1039/c9ra08169k}

}

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Shpichka, Anastasia I., et al. “Digging deeper: structural background of PEGylated fibrin gels in cell migration and lumenogenesis.” RSC Advances, vol. 10, no. 8, Jan. 2020, pp. 4190-4200. https://xlink.rsc.org/?DOI=C9RA08169K.