Open Access

Chemical Science, volume 10, issue 32, pages 7641-7648

Total synthesis of griseusins and elucidation of the griseusin mechanism of action

Yinan Zhang ^{1, 2, 3}

Qing Ye ⁴

Larissa Ponomareva ^{2, 3}

Yanan Cao ⁴

Y Liu ^{2, 3}

Zheng Cui ³

Steven G. Van Lanen ³

S. Voss ⁵

Qing-Bai SHE ⁴

Jon S. Thorson ^{2, 3}

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Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China |

Center for Pharmaceutical Research and Innovation, University of Kentucky, Lexington, KY 40536, USA |

College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA |

⁴

Markey Cancer Center, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY 40536, USA |

⁵

Department of Neuroscience, Spinal Cord and Brain Injury Research Center, Ambystoma Genetic Stock Center, University of Kentucky, Lexington, KY 40536, USA |

Publication type: Journal Article

Publication date: 2019-06-27

Royal Society of Chemistry (RSC)

Journal: Chemical Science

scimago Q1

SJR: 2.333

CiteScore: 14.4

Impact factor: 7.6

ISSN: 20416520, 20416539

DOI: 10.1039/c9sc02289a

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General Chemistry

Abstract

An efficient divergent synthesis of griseusins enabled SAR studies, mechanistic elucidation and evaluation in an axolotl tail regeneration model.

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Publisher

Royal Society of Chemistry (RSC)

Journal

Chemical Science

scimago Q1

SJR

2.333

CiteScore

14.4

Impact factor

7.6

ISSN

20416520 (Print)

20416539 (Electronic)

Total synthesis of griseusins and elucidation of the griseusin mechanism of action

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