Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity
Yangbin Liang
1, 2, 3, 4, 5, 6, 7
,
Xinshuang Zhang
1, 2, 3, 4, 5, 6, 7
,
Yueling Yuan
1, 3, 4, 5, 6, 7, 8
,
Yan BAO Yan
9
,
Yan Bao
6, 9, 10, 11, 12, 13
,
Menghua Xiong
1, 2, 3, 4, 5, 6, 7, 14
3
Guangzhou First People's Hospital
|
4
School of Biomedical Sciences and Engineering
5
South china university of technology
|
6
GuangZhou
7
P. R. China
|
10
Medical Research Center
11
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation
|
12
Sun Yat-Sen Memorial Hospital
Publication type: Journal Article
Publication date: 2020-07-24
scimago Q1
wos Q2
SJR: 1.215
CiteScore: 11.4
Impact factor: 5.7
ISSN: 20474830, 20474849
PubMed ID:
32815940
General Materials Science
Biomedical Engineering
Abstract
Since the development of bacterial resistance, the decreasing effectiveness of antibiotics is becoming one of the most critical problems worldwide. Novel antibacterial agents are urgently needed to prevent humanity from falling back into the “post-antibiotic era”. As an important part of the innate immune system, antimicrobial peptides (AMPs) are one of the most promising antibacterial agents showing broad-spectrum activity against bacteria and low propensity for drug resistance. However, the shortcomings of AMPs, such as high toxicity and easy digestion by proteases, limit their clinical application. This review mainly focuses on the effect of the secondary structure on the antimicrobial activity and cytotoxicity of AMPs and the strategies of designing conformationally transitionable AMPs with improved selectivity towards bacteria.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
|
|
|
Antibiotics
3 publications, 3.3%
|
|
|
European Journal of Medicinal Chemistry
3 publications, 3.3%
|
|
|
Scientific Reports
2 publications, 2.2%
|
|
|
Pharmaceutics
2 publications, 2.2%
|
|
|
Frontiers in Microbiology
2 publications, 2.2%
|
|
|
International Journal of Biological Macromolecules
2 publications, 2.2%
|
|
|
Briefings in Bioinformatics
2 publications, 2.2%
|
|
|
Journal of Materials Chemistry B
2 publications, 2.2%
|
|
|
Biomaterials Science
2 publications, 2.2%
|
|
|
Advanced Science
2 publications, 2.2%
|
|
|
Science China Materials
2 publications, 2.2%
|
|
|
Molecules
2 publications, 2.2%
|
|
|
Catalysts
1 publication, 1.1%
|
|
|
Future Medicinal Chemistry
1 publication, 1.1%
|
|
|
Toxins
1 publication, 1.1%
|
|
|
Botanical Studies
1 publication, 1.1%
|
|
|
Nature Nanotechnology
1 publication, 1.1%
|
|
|
Mendeleev Communications
1 publication, 1.1%
|
|
|
Trends in Pharmacological Sciences
1 publication, 1.1%
|
|
|
Coordination Chemistry Reviews
1 publication, 1.1%
|
|
|
Acta Biomaterialia
1 publication, 1.1%
|
|
|
Progress in Polymer Science
1 publication, 1.1%
|
|
|
Giant
1 publication, 1.1%
|
|
|
Advanced Drug Delivery Reviews
1 publication, 1.1%
|
|
|
Nano Today
1 publication, 1.1%
|
|
|
Bioorganic Chemistry
1 publication, 1.1%
|
|
|
Computational and Structural Biotechnology Journal
1 publication, 1.1%
|
|
|
Angewandte Chemie - International Edition
1 publication, 1.1%
|
|
|
Angewandte Chemie
1 publication, 1.1%
|
|
|
1
2
3
|
Publishers
|
5
10
15
20
25
|
|
|
Elsevier
25 publications, 27.47%
|
|
|
Springer Nature
13 publications, 14.29%
|
|
|
Wiley
12 publications, 13.19%
|
|
|
MDPI
11 publications, 12.09%
|
|
|
American Chemical Society (ACS)
9 publications, 9.89%
|
|
|
Royal Society of Chemistry (RSC)
8 publications, 8.79%
|
|
|
Taylor & Francis
2 publications, 2.2%
|
|
|
Frontiers Media S.A.
2 publications, 2.2%
|
|
|
Oxford University Press
2 publications, 2.2%
|
|
|
Cold Spring Harbor Laboratory
2 publications, 2.2%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 1.1%
|
|
|
American Society for Microbiology
1 publication, 1.1%
|
|
|
American Association for the Advancement of Science (AAAS)
1 publication, 1.1%
|
|
|
Science Alert
1 publication, 1.1%
|
|
|
5
10
15
20
25
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
92
Total citations:
92
Citations from 2025:
23
(25.27%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Liang Y. et al. Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity // Biomaterials Science. 2020. Vol. 8. No. 24. pp. 6858-6866.
GOST all authors (up to 50)
Copy
Liang Y., Zhang X., Yuan Y., BAO Yan Y., Bao Y., Xiong M. Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity // Biomaterials Science. 2020. Vol. 8. No. 24. pp. 6858-6866.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/d0bm00801j
UR - https://xlink.rsc.org/?DOI=D0BM00801J
TI - Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity
T2 - Biomaterials Science
AU - Liang, Yangbin
AU - Zhang, Xinshuang
AU - Yuan, Yueling
AU - BAO Yan, Yan
AU - Bao, Yan
AU - Xiong, Menghua
PY - 2020
DA - 2020/07/24
PB - Royal Society of Chemistry (RSC)
SP - 6858-6866
IS - 24
VL - 8
PMID - 32815940
SN - 2047-4830
SN - 2047-4849
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Liang,
author = {Yangbin Liang and Xinshuang Zhang and Yueling Yuan and Yan BAO Yan and Yan Bao and Menghua Xiong},
title = {Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity},
journal = {Biomaterials Science},
year = {2020},
volume = {8},
publisher = {Royal Society of Chemistry (RSC)},
month = {jul},
url = {https://xlink.rsc.org/?DOI=D0BM00801J},
number = {24},
pages = {6858--6866},
doi = {10.1039/d0bm00801j}
}
Cite this
MLA
Copy
Liang, Yangbin, et al. “Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity.” Biomaterials Science, vol. 8, no. 24, Jul. 2020, pp. 6858-6866. https://xlink.rsc.org/?DOI=D0BM00801J.