CrystEngComm

, volume 22 , issue 16 , pages 2705-2708

Discovery of new polymorphs of the tuberculosis drug isoniazid

Keke Zhang ^{1, 2, 3, 4, 5, 6, 7}

Noalle Fellah ^{1, 3, 4, 5, 6}

A. G. Shtukenberg ^{1, 3, 4, 5, 6}

Xiaoyan Fu ^{8, 9, 10, 11, 12, 13}

Chun-hua Hu ^{1, 3, 4, 5, 6}

Michael D Ward ^{1, 3, 4, 5, 6}

Hide authors affiliations Show authors affiliations: 13 affiliations

Department of Chemistry and Molecular Design Institute, New York University, New York City, NY, USA |

School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, People's Republic of China |

Department of Chemistry and Molecular Design Institute

⁴

New York University |

⁵

NEW YORK CITY |

⁶

Usa |

⁷

School of Chemical Engineering and Technology

⁸

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People's Republic of China |

⁹

State Key Laboratory of Catalysis

¹⁰

Dalian Institute of Chemical Physics |

¹¹

Chinese Academy of sciences

¹²

Dalian 116023 |

¹³

People's Republic of China |

Publication type: Journal Article

Publication date: 2020-04-08

Royal Society of Chemistry (RSC)

CrystEngComm

scimago Q2

wos Q2

SJR: 0.520

CiteScore: 5.2

Impact factor: 2.6

ISSN: 14668033

DOI: 10.1039/d0ce00440e

Copy DOI

General Chemistry

Condensed Matter Physics

General Materials Science

Abstract

Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement. The two new forms are readily distinguished from the known form by optical microscopy, Raman spectroscopy and X-ray powder diffraction. A single crystal structure was obtained for one of the new polymorphs.

Found

1 citation

Eremenko Igor

DSc in Chemistry, professor, full member of the Russian Academy of Sciences

675 publications, 7 817 citations, 29 reviews

h-index: 35

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

1 citation

Rumyantcev Roman

PhD in Chemistry

133 publications, 1 025 citations, 23 reviews

h-index: 16

G. A. Razuvaev Institute of Organometallic Chemistry of the Russian Academy of Sciences

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GOST |

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GOST Copy

Zhang K. et al. Discovery of new polymorphs of the tuberculosis drug isoniazid // CrystEngComm. 2020. Vol. 22. No. 16. pp. 2705-2708.

GOST all authors (up to 50) Copy

Zhang K., Fellah N., Shtukenberg A. G., Fu X., Hu C., Ward M. D. Discovery of new polymorphs of the tuberculosis drug isoniazid // CrystEngComm. 2020. Vol. 22. No. 16. pp. 2705-2708.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1039/d0ce00440e

UR - https://xlink.rsc.org/?DOI=D0CE00440E

TI - Discovery of new polymorphs of the tuberculosis drug isoniazid

T2 - CrystEngComm

AU - Zhang, Keke

AU - Fellah, Noalle

AU - Shtukenberg, A. G.

AU - Fu, Xiaoyan

AU - Hu, Chun-hua

AU - Ward, Michael D

PY - 2020

DA - 2020/04/08

PB - Royal Society of Chemistry (RSC)

SP - 2705-2708

IS - 16

VL - 22

SN - 1466-8033

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Zhang,

author = {Keke Zhang and Noalle Fellah and A. G. Shtukenberg and Xiaoyan Fu and Chun-hua Hu and Michael D Ward},

title = {Discovery of new polymorphs of the tuberculosis drug isoniazid},

journal = {CrystEngComm},

year = {2020},

volume = {22},

publisher = {Royal Society of Chemistry (RSC)},

month = {apr},

url = {https://xlink.rsc.org/?DOI=D0CE00440E},

number = {16},

pages = {2705--2708},

doi = {10.1039/d0ce00440e}

}

MLA

Cite this

MLA Copy

Zhang, Keke, et al. “Discovery of new polymorphs of the tuberculosis drug isoniazid.” CrystEngComm, vol. 22, no. 16, Apr. 2020, pp. 2705-2708. https://xlink.rsc.org/?DOI=D0CE00440E.

Publisher

Royal Society of Chemistry (RSC)

Journal

CrystEngComm

scimago Q2

wos Q2

SJR

0.520

CiteScore

5.2

Impact factor

2.6

ISSN

14668033 (Print, Electronic)

Profiles

Alexander G Shtukenberg