Dalton Transactions

, volume 50 , issue 23 , pages 7922-7927

Alternative mechanism of action of the DNP Pt^IVprodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway

Olga O. Krasnovskaya ^{1, 2, 3, 4, 5, 6, 7}

Daniil Spector ^{1, 2}

Alexander V. Erofeev ^{1, 2, 3, 4, 5, 6, 7}

Peter Gorelkin ^{1, 2}

Roman A. Akasov ^{5, 6, 8, 9, 10, 11, 12}

Dmitry Skvortsov ^{1, 3, 4, 5, 6, 13, 14}

Alexander L. Trigub ¹⁵

Alexander Trigub ^{5, 6, 16}

Ksenia Vlasova ^{1, 3, 4, 5, 6}

Alevtina Semkina ^{5, 6, 17, 18, 19, 20, 21}

Nikolay Zyk ^{1, 3, 4, 5, 6}

Elena K. Beloglazkina ^{1, 3, 4, 5, 6}

Alexander G. Majouga ^{1, 2, 22}

Alexander Majouga ^{3, 4, 5, 6, 7}

Hide authors affiliations Show authors affiliations: 22 affiliations

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, Russia |

National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow, Russia |

Chemistry department

⁴

Lomonosov Moscow State University |

⁵

Moscow

⁶

Russia |

⁷

National University of Science and Technology (MISiS) |

⁸

I.M. Sechenov First Moscow State Medical University, Trubetskaya str. 8-2, Moscow, Russia |

⁹

Federal Scientific Research Center “Crystallography and Photonics” Russian Academy of Sciences, Leninskiy Prospect 59, Moscow, Russia |

¹⁰

I.M. Sechenov First Moscow State Medical University |

¹¹

Federal Scientific Research Center “Crystallography and Photonics” Russian Academy of Sciences |

¹²

Leninskiy Prospect 59

¹³

Faculty of biology and biotechnologies, Higher School of Economics, Myasnitskaya 13, Moscow, Russia |

¹⁴

Faculty of biology and biotechnologies

¹⁵

National Research Center “Kurchatov Institute”, Akademika Kurchatova pl., 1, Moscow, Russia |

¹⁶

National Research Center “Kurchatov Institute” |

¹⁷

Pirogov Russian National Research Medical University (RNRMU), Ostrovitianov str. 1, Moscow, Russia |

¹⁸

Serbsky National Medical Research Center for Psychiatry and Narcology, Department of Basic and Applied Neurobiology, Kropotkinskiy 23, Moscow 119991, Russia |

¹⁹

Pirogov Russian National Research Medical University (RNRMU) |

²⁰

Serbsky National Medical Research Center for Psychiatry and Narcology |

²¹

Department of Basic and Applied Neurobiology

²²

Mendeleev University of Chemical Technology of Russia, Miusskaya Ploshchad’ 9, Moscow, Russia |

Publication type: Journal Article

Publication date: 2021-04-20

Royal Society of Chemistry (RSC)

Dalton Transactions

scimago Q2

wos Q1

SJR: 0.653

CiteScore: 6.0

Impact factor: 3.3

ISSN: 14779226, 14779234

DOI: 10.1039/d1dt00898f

Copy DOI

PubMed ID: 34037020

Inorganic Chemistry

Abstract

In a recent research paper Dr. Suxing Jin et al. reported two multispecific PtIV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.

Found

5 citations

Krasnovskaya Olga

52 publications, 862 citations, 10 reviews

h-index: 17

Lomonosov Moscow State University

4 citations

Beloglazkina Elena

DSc in Chemistry, professor

296 publications, 3 214 citations, 11 reviews

h-index: 29

Lomonosov Moscow State University

3 citations

Skvortsov Dmitry

🥼

PhD in Chemistry

128 publications, 1 834 citations, 1 review

h-index: 26

Lomonosov Moscow State University

3 citations

Akasov Roman

🥼 🤝

PhD in Biological/biomedical sciences

73 publications, 1 270 citations, 26 reviews

h-index: 22

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Kurchatov Complex of Crystallography and Photonics of NRC «Kurchatov Institute»

Sechenov First Moscow State Medical University

2 citations

Trigub Alexander

PhD in Physics and Mathematics

183 publications, 2 216 citations

h-index: 27

National Research Centre "Kurchatov Institute"

Research interests

X-ray absorption spectroscopy

1 citation

Soldatov Mikhail

PhD

99 publications, 2 385 citations

h-index: 25

Southern Federal University

1 citation

Mazur Dmitrii

🤝

PhD in Chemistry

66 publications, 766 citations, 2 reviews

h-index: 18

Lomonosov Moscow State University

Shenzhen MSU-BIT University

Research interests

Astrochemistry

Bioorganic chemistry

Disinfection of water

Ecology

Environmental Chemistry

Environmental Science

Mass Spectrometry

Organic Chemistry

Peptides

Synthetic Organic Chemistry

1 citation

Finko Alexander

PhD in Chemistry, associate professor

49 publications, 225 citations, 2 reviews

h-index: 8

A.V. Topchiev Institute of Petrochemical Synthesis RAS

Lomonosov Moscow State University

1 citation

Abakumov Maxim

PhD in Chemistry, associate professor

159 publications, 2 662 citations, 19 reviews

h-index: 28

National University of Science & Technology (MISiS)

Pirogov Russian National Research Medical University

1 citation

Kuzmin Vladimir

393 publications, 2 905 citations

h-index: 27

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

1 citation

Aksenov Aleksandr

🥼 🤝

DSc in Chemistry, professor

243 publications, 2 163 citations, 15 reviews

h-index: 24

North Caucasus Federal University

Research interests

Medicinal Chemistry

Organic Chemistry

1 citation

Sosnovskikh Vyacheslav

DSc in Chemistry, professor

355 publications, 4 707 citations

h-index: 30

Ural Federal University

1 citation

Ivleva Elena

67 publications, 465 citations

h-index: 12

Samara State Technical University

Research interests

Organic Chemistry

Organic synthesis

Top-30

Journals

	1
Analytical Chemistry	Analytical Chemistry, 1, 10% Analytical Chemistry 1 publication, 10%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 1, 10% Journal of Medicinal Chemistry 1 publication, 10%
Inorganic Chemistry	Inorganic Chemistry, 1, 10% Inorganic Chemistry 1 publication, 10%
Dalton Transactions	Dalton Transactions, 1, 10% Dalton Transactions 1 publication, 10%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 10% Russian Chemical Reviews 1 publication, 10%
Topics in Current Chemistry	Topics in Current Chemistry, 1, 10% Topics in Current Chemistry 1 publication, 10%
Russian Journal of Organic Chemistry	Russian Journal of Organic Chemistry, 1, 10% Russian Journal of Organic Chemistry 1 publication, 10%
Журнал органической химии	Журнал органической химии, 1, 10% Журнал органической химии 1 publication, 10%
Angewandte Chemie	Angewandte Chemie, 1, 10% Angewandte Chemie 1 publication, 10%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 1, 10% Angewandte Chemie - International Edition 1 publication, 10%
	1

Publishers

	1 2 3
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 30% American Chemical Society (ACS) 3 publications, 30%
Wiley	Wiley, 2, 20% Wiley 2 publications, 20%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 10% Royal Society of Chemistry (RSC) 1 publication, 10%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 10% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 10%
Springer Nature	Springer Nature, 1, 10% Springer Nature 1 publication, 10%
Pleiades Publishing	Pleiades Publishing, 1, 10% Pleiades Publishing 1 publication, 10%
The Russian Academy of Sciences	The Russian Academy of Sciences, 1, 10% The Russian Academy of Sciences 1 publication, 10%
	1 2 3

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Krasnovskaya O. O. et al. Alternative mechanism of action of the DNP PtIVprodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway // Dalton Transactions. 2021. Vol. 50. No. 23. pp. 7922-7927.

GOST all authors (up to 50) Copy

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1039/d1dt00898f

UR - https://xlink.rsc.org/?DOI=D1DT00898F

TI - Alternative mechanism of action of the DNP PtIVprodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway

T2 - Dalton Transactions

AU - Krasnovskaya, Olga O.

AU - Spector, Daniil

AU - Erofeev, Alexander V.

AU - Gorelkin, Peter

AU - Akasov, Roman A.

AU - Skvortsov, Dmitry

AU - Trigub, Alexander L.

AU - Trigub, Alexander

AU - Vlasova, Ksenia

AU - Semkina, Alevtina

AU - Zyk, Nikolay

AU - Beloglazkina, Elena K.

AU - Majouga, Alexander G.

AU - Majouga, Alexander

PY - 2021

DA - 2021/04/20

PB - Royal Society of Chemistry (RSC)

SP - 7922-7927

IS - 23

VL - 50

PMID - 34037020

SN - 1477-9226

SN - 1477-9234

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Krasnovskaya,

author = {Olga O. Krasnovskaya and Daniil Spector and Alexander V. Erofeev and Peter Gorelkin and Roman A. Akasov and Dmitry Skvortsov and Alexander L. Trigub and Alexander Trigub and Ksenia Vlasova and Alevtina Semkina and Nikolay Zyk and Elena K. Beloglazkina and Alexander G. Majouga and Alexander Majouga and others},

title = {Alternative mechanism of action of the DNP PtIVprodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway},

journal = {Dalton Transactions},

year = {2021},

volume = {50},

publisher = {Royal Society of Chemistry (RSC)},

month = {apr},

url = {https://xlink.rsc.org/?DOI=D1DT00898F},

number = {23},

pages = {7922--7927},

doi = {10.1039/d1dt00898f}

}

MLA

Cite this

MLA Copy

Krasnovskaya, Olga O., et al. “Alternative mechanism of action of the DNP PtIVprodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway.” Dalton Transactions, vol. 50, no. 23, Apr. 2021, pp. 7922-7927. https://xlink.rsc.org/?DOI=D1DT00898F.

Publisher

Royal Society of Chemistry (RSC)

Journal

Dalton Transactions

scimago Q2

wos Q1

SJR

0.653

CiteScore

6.0

Impact factor

3.3

ISSN

14779226 (Print)

14779234 (Electronic)

Labs

Laboratory of Biologically Active Organic Compounds (BAOС)

Profiles