Towards potential antifungal agents: synthesis, supramolecular self-assembly and in vitro activity of azole mono-, sesqui- and diterpenoids
Alan Akhmedov
1, 2
,
Rustem Gamirov
1
,
Yulia Panina
1
,
Elina Sokolova
3
,
Yulia Leonteva
3
,
Evgeniya Tarasova
2
,
Ramziya Potekhina
2
,
Igor Fitsev
2
,
Ivan Stoikov
1, 2
1
Publication type: Journal Article
Publication date: 2023-05-24
scimago Q2
wos Q2
SJR: 0.600
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
PubMed ID:
37249394
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
Terpenes and their derivatives are natural antifungal and antimicrobial agents. In this paper, potential antifungal agents were developed on the basis of farnesol, geraniol, myrtenol, perillyl alcohol, cedrol and phytol. The synthesized compounds exist in aqueous solutions as stable associates (D = 142–216 nm, PDI 0.04–0.16, Z = +0.9–+46 mV). Formation of stable associates of the compounds in solution promotes compaction and dosed release of the drug. The membranotropic activity of the compounds was also investigated to open up their possible application in the treatment of skin diseases. The relationship between membranotropism and lipophilicity coefficient (log P) has been established. The antifungal and antimicrobial activities of the obtained compounds were studied in vitro on the clinical isolate of Candida sp., Candida albicans, yeast Saccharomyces cerevisiae, Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus, Bifidobacterium bifidum) bacteria. Candida sp. (0.0781 mg mL−1) and Saccharomyces cerevisiae (0.0049 mg mL−1) showed the highest sensitivity to the agents.
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18
Total citations:
18
Citations from 2024:
14
(77.78%)
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GOST
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Akhmedov A. et al. Towards potential antifungal agents: synthesis, supramolecular self-assembly and in vitro activity of azole mono-, sesqui- and diterpenoids // Organic and Biomolecular Chemistry. 2023. Vol. 21. No. 23. pp. 4863-4873.
GOST all authors (up to 50)
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Akhmedov A., Gamirov R., Panina Y., Sokolova E., Leonteva Y., Tarasova E., Potekhina R., Fitsev I., Shurpik D. N., Stoikov I. Towards potential antifungal agents: synthesis, supramolecular self-assembly and in vitro activity of azole mono-, sesqui- and diterpenoids // Organic and Biomolecular Chemistry. 2023. Vol. 21. No. 23. pp. 4863-4873.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/d3ob00528c
UR - https://xlink.rsc.org/?DOI=D3OB00528C
TI - Towards potential antifungal agents: synthesis, supramolecular self-assembly and in vitro activity of azole mono-, sesqui- and diterpenoids
T2 - Organic and Biomolecular Chemistry
AU - Akhmedov, Alan
AU - Gamirov, Rustem
AU - Panina, Yulia
AU - Sokolova, Elina
AU - Leonteva, Yulia
AU - Tarasova, Evgeniya
AU - Potekhina, Ramziya
AU - Fitsev, Igor
AU - Shurpik, Dmitriy N
AU - Stoikov, Ivan
PY - 2023
DA - 2023/05/24
PB - Royal Society of Chemistry (RSC)
SP - 4863-4873
IS - 23
VL - 21
PMID - 37249394
SN - 1477-0520
SN - 1477-0539
ER -
Cite this
BibTex (up to 50 authors)
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@article{2023_Akhmedov,
author = {Alan Akhmedov and Rustem Gamirov and Yulia Panina and Elina Sokolova and Yulia Leonteva and Evgeniya Tarasova and Ramziya Potekhina and Igor Fitsev and Dmitriy N Shurpik and Ivan Stoikov},
title = {Towards potential antifungal agents: synthesis, supramolecular self-assembly and in vitro activity of azole mono-, sesqui- and diterpenoids},
journal = {Organic and Biomolecular Chemistry},
year = {2023},
volume = {21},
publisher = {Royal Society of Chemistry (RSC)},
month = {may},
url = {https://xlink.rsc.org/?DOI=D3OB00528C},
number = {23},
pages = {4863--4873},
doi = {10.1039/d3ob00528c}
}
Cite this
MLA
Copy
Akhmedov, Alan, et al. “Towards potential antifungal agents: synthesis, supramolecular self-assembly and in vitro activity of azole mono-, sesqui- and diterpenoids.” Organic and Biomolecular Chemistry, vol. 21, no. 23, May. 2023, pp. 4863-4873. https://xlink.rsc.org/?DOI=D3OB00528C.