volume 76 issue 16 pages 1896-1900

Pterosins fromPteris multifida

Dan Wei Ouyang 1
1
 
Department of Chinese Traditional Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, P R China.
Publication typeJournal Article
Publication date2010-05-19
scimago Q2
wos Q2
SJR0.427
CiteScore4.5
Impact factor2.0
ISSN00320943, 14390221
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
A new C(14) pterosin sesquiterpenoid, named (2R)-pterosin P (1), and a new natural product, named dehydropterosin B (3), were isolated from the aerial parts of Pteris multifida Poir., along with nine known compounds (2, 4-11). By chiral HPLC, compounds 1 and 2 were isolated as a pair of enantiomeric pterosin sesquiterpenoids. The planar structure of 1 was elucidated on the basis of NMR spectroscopy analysis, and the absolute configuration was established by the CD spectrum. In addition, the absolute structure of 1 was further confirmed by single-crystal X-ray diffraction (CuK α). Compounds 3, 5, and 6 showed potent cytotoxicity against PANC-1 (human pancreatic cancer) and NCI-H446 (human small-cell lung cancer) cell lines, with IC(50) values in the range of 4.27-14.63 µM.
Found 
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GOST |
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GOST Copy
Ouyang D. W. Pterosins fromPteris multifida // Planta Medica. 2010. Vol. 76. No. 16. pp. 1896-1900.
GOST all authors (up to 50) Copy
Ouyang D. W. Pterosins fromPteris multifida // Planta Medica. 2010. Vol. 76. No. 16. pp. 1896-1900.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1055/s-0030-1249934
UR - https://doi.org/10.1055/s-0030-1249934
TI - Pterosins fromPteris multifida
T2 - Planta Medica
AU - Ouyang, Dan Wei
PY - 2010
DA - 2010/05/19
PB - Georg Thieme Verlag KG
SP - 1896-1900
IS - 16
VL - 76
PMID - 20486077
SN - 0032-0943
SN - 1439-0221
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2010_Ouyang,
author = {Dan Wei Ouyang},
title = {Pterosins fromPteris multifida},
journal = {Planta Medica},
year = {2010},
volume = {76},
publisher = {Georg Thieme Verlag KG},
month = {may},
url = {https://doi.org/10.1055/s-0030-1249934},
number = {16},
pages = {1896--1900},
doi = {10.1055/s-0030-1249934}
}
MLA
Cite this
MLA Copy
Ouyang, Dan Wei. “Pterosins fromPteris multifida.” Planta Medica, vol. 76, no. 16, May. 2010, pp. 1896-1900. https://doi.org/10.1055/s-0030-1249934.
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