Synthesis, issue 2, pages 201-204

Stereoselective Syntheses of (E)-α,β-Dehydroamino Acids and (E)-α,β-De­hydropeptides by Stereospecific Dehydration with 1-Ethyl-3-(3-dimethyl­aminopropyl)carbodiimide (EDC)

Hiroshi Sai
Tsuyoshi Ogiku
Hiroshi Ohmizu
Publication typeJournal Article
Publication date2003-01-23
Journal: Synthesis
scimago Q2
SJR0.582
CiteScore4.5
Impact factor2.2
ISSN00397881, 1437210X
Catalysis
Organic Chemistry
Abstract
Highly stereoselective syntheses of (E)-α,β-dehydroamino acids and (E)-α,β-dehydropeptides have been achieved in good yields by stereospecific dehydration of threo-β-hydroxy-α-amino acid derivatives using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and CuCl 2 .
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