Direct Catalytic Benzylation of Hydroxycoumarin - Efficient Synthesis of Warfarin Derivatives and Analogues
Тип публикации: Journal Article
Дата публикации: 2010-05-10
scimago Q3
wos Q3
БС2
SJR: 0.437
CiteScore: 3.3
Impact factor: 1.4
ISSN: 09365214, 14372096
Organic Chemistry
Краткое описание
Effective metal-catalyzed benzylations of 4-hydroxycoumarin have been developed. Employing a low amount of a cheap, nontoxic, and air-stable catalyst the 3-alkylated hydroxycoumarins were isolated in high yields after short reaction times. Applying this new methodology two widely used anticoagulants phenprocoumon and coumatetralyl were synthesized applying mild reaction conditions.
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Rueping M., Nachtsheim B. J., Sugiono E. Direct Catalytic Benzylation of Hydroxycoumarin - Efficient Synthesis of Warfarin Derivatives and Analogues // Synlett. 2010. Vol. 2010. No. 10. pp. 1549-1553.
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Rueping M., Nachtsheim B. J., Sugiono E. Direct Catalytic Benzylation of Hydroxycoumarin - Efficient Synthesis of Warfarin Derivatives and Analogues // Synlett. 2010. Vol. 2010. No. 10. pp. 1549-1553.
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TY - JOUR
DO - 10.1055/s-0029-1219936
UR - https://doi.org/10.1055/s-0029-1219936
TI - Direct Catalytic Benzylation of Hydroxycoumarin - Efficient Synthesis of Warfarin Derivatives and Analogues
T2 - Synlett
AU - Rueping, Magnus
AU - Nachtsheim, Boris J
AU - Sugiono, Erli
PY - 2010
DA - 2010/05/10
PB - Georg Thieme Verlag KG
SP - 1549-1553
IS - 10
VL - 2010
SN - 0936-5214
SN - 1437-2096
ER -
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BibTex (до 50 авторов)
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@article{2010_Rueping,
author = {Magnus Rueping and Boris J Nachtsheim and Erli Sugiono},
title = {Direct Catalytic Benzylation of Hydroxycoumarin - Efficient Synthesis of Warfarin Derivatives and Analogues},
journal = {Synlett},
year = {2010},
volume = {2010},
publisher = {Georg Thieme Verlag KG},
month = {may},
url = {https://doi.org/10.1055/s-0029-1219936},
number = {10},
pages = {1549--1553},
doi = {10.1055/s-0029-1219936}
}
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MLA
Скопировать
Rueping, Magnus, et al. “Direct Catalytic Benzylation of Hydroxycoumarin - Efficient Synthesis of Warfarin Derivatives and Analogues.” Synlett, vol. 2010, no. 10, May. 2010, pp. 1549-1553. https://doi.org/10.1055/s-0029-1219936.