Synthesis and Biological Activity of 4-(Pyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic Acid Derivatives
3
Republican State Enterprise ‘National Center for Biotechnology’ under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan
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4
Kokshetau State University named after Sh. Ualikhanov
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6
Institute of Bioorganic Chemistry
Publication type: Journal Article
Publication date: 2019-11-29
scimago Q3
wos Q3
SJR: 0.437
CiteScore: 3.3
Impact factor: 1.4
ISSN: 09365214, 14372096
Organic Chemistry
Abstract
Claisen condensation reaction of diethyl oxalate with 1-[4-(furan-2-yl)-2-methyl-5-nitro-6-phenylpyridin-3-yl]ethan-1-one afforded (Z)-4-[4-(furan-2-yl)-2-methyl-5-nitro-6-phenylpyridin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid. The latter reacted with various binucleophiles to form the corresponding 3,4-dihydroquinoxaline-2(1H)-one, 3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one, and 1H-pyrazole derivatives. Biological screening of the obtained compounds revealed analgesic and antibacterial activity.
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Total citations:
8
Citations from 2024:
3
(37.5%)
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GOST
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Oleshchuk A. L. et al. Synthesis and Biological Activity of 4-(Pyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic Acid Derivatives // Synlett. 2019. Vol. 31. No. 2. pp. 165-170.
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Oleshchuk A. L., Shulgau Z. T., Seilkhanov T. M., Vasilchenko A. S., Talipov S. A., Kulakov I. V. Synthesis and Biological Activity of 4-(Pyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic Acid Derivatives // Synlett. 2019. Vol. 31. No. 2. pp. 165-170.
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RIS
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TY - JOUR
DO - 10.1055/s-0037-1610738
UR - https://doi.org/10.1055/s-0037-1610738
TI - Synthesis and Biological Activity of 4-(Pyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic Acid Derivatives
T2 - Synlett
AU - Oleshchuk, Alena L
AU - Shulgau, Zarina T.
AU - Seilkhanov, Tulegen M
AU - Vasilchenko, Alexey S.
AU - Talipov, Samat A.
AU - Kulakov, Ivan V.
PY - 2019
DA - 2019/11/29
PB - Georg Thieme Verlag KG
SP - 165-170
IS - 2
VL - 31
SN - 0936-5214
SN - 1437-2096
ER -
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BibTex (up to 50 authors)
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@article{2019_Oleshchuk,
author = {Alena L Oleshchuk and Zarina T. Shulgau and Tulegen M Seilkhanov and Alexey S. Vasilchenko and Samat A. Talipov and Ivan V. Kulakov},
title = {Synthesis and Biological Activity of 4-(Pyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic Acid Derivatives},
journal = {Synlett},
year = {2019},
volume = {31},
publisher = {Georg Thieme Verlag KG},
month = {nov},
url = {https://doi.org/10.1055/s-0037-1610738},
number = {2},
pages = {165--170},
doi = {10.1055/s-0037-1610738}
}
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MLA
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Oleshchuk, Alena L., et al. “Synthesis and Biological Activity of 4-(Pyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic Acid Derivatives.” Synlett, vol. 31, no. 2, Nov. 2019, pp. 165-170. https://doi.org/10.1055/s-0037-1610738.
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