Modulation of the G2Cell Cycle Checkpoint by Sesquiterpene Lactones Psilostachyins A and C Isolated from the Common RagweedAmbrosia artemisiifolia
Publication type: Journal Article
Publication date: 2005-09-01
scimago Q2
wos Q2
SJR: 0.427
CiteScore: 4.5
Impact factor: 2.0
ISSN: 00320943, 14390221
PubMed ID:
16254826
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
A phenotypic cell-based assay for inhibitors of the G (2) DNA damage checkpoint was used to screen plant extracts from the US National Cancer Institute Natural Products Repository. It revealed activity in a methanol extract from the common ragweed Ambrosia artemisiifolia. Assay-guided fractionation led to the identification of the sesquiterpene lactones psilostachyins A and C as novel checkpoint inhibitors. Elimination of their alpha,beta-unsaturated carbonyl group caused a loss of activity, suggesting that the compounds can bind covalently to target proteins through Michael addition. Psilostachyins A and C also blocked cells in mitosis and caused the formation of aberrant microtubule spindles. However, the compounds did not interfere with microtubule polymerization in vitro. The related sesquiterpene lactones psilostachyin B, paulitin and isopaulitin were also isolated from the same extract but showed no checkpoint inhibition. The identification of the target(s) of psilostachyins A and C may provide further insight into the signalling pathways involved in cell cycle arrest and mitotic progression.
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Total citations:
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Citations from 2025:
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Sturgeon C. M. Modulation of the G2Cell Cycle Checkpoint by Sesquiterpene Lactones Psilostachyins A and C Isolated from the Common RagweedAmbrosia artemisiifolia // Planta Medica. 2005. Vol. 71. No. 10. pp. 938-943.
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Sturgeon C. M. Modulation of the G2Cell Cycle Checkpoint by Sesquiterpene Lactones Psilostachyins A and C Isolated from the Common RagweedAmbrosia artemisiifolia // Planta Medica. 2005. Vol. 71. No. 10. pp. 938-943.
Cite this
RIS
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TY - JOUR
DO - 10.1055/s-2005-873109
UR - https://doi.org/10.1055/s-2005-873109
TI - Modulation of the G2Cell Cycle Checkpoint by Sesquiterpene Lactones Psilostachyins A and C Isolated from the Common RagweedAmbrosia artemisiifolia
T2 - Planta Medica
AU - Sturgeon, Christopher M
PY - 2005
DA - 2005/09/01
PB - Georg Thieme Verlag KG
SP - 938-943
IS - 10
VL - 71
PMID - 16254826
SN - 0032-0943
SN - 1439-0221
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2005_Sturgeon,
author = {Christopher M Sturgeon},
title = {Modulation of the G2Cell Cycle Checkpoint by Sesquiterpene Lactones Psilostachyins A and C Isolated from the Common RagweedAmbrosia artemisiifolia},
journal = {Planta Medica},
year = {2005},
volume = {71},
publisher = {Georg Thieme Verlag KG},
month = {sep},
url = {https://doi.org/10.1055/s-2005-873109},
number = {10},
pages = {938--943},
doi = {10.1055/s-2005-873109}
}
Cite this
MLA
Copy
Sturgeon, Christopher M.. “Modulation of the G2Cell Cycle Checkpoint by Sesquiterpene Lactones Psilostachyins A and C Isolated from the Common RagweedAmbrosia artemisiifolia.” Planta Medica, vol. 71, no. 10, Sep. 2005, pp. 938-943. https://doi.org/10.1055/s-2005-873109.