Synthesis of 7-formyl methyl abietate via Vilsmeier-Haack reaction and cytotoxic activity of abietane diterpene derivatives

Publication type: Proceedings Article
Publication date: 2022-02-04
AIP Publishing
SJR: 0.153
CiteScore: 0.5
Impact factor: —
ISSN: 0094243X, 15517616
Abstract
Synthesis of methyl 7-formylabieta-7,13-dien-18-oate was achieved by formylation of the abietic acid methyl ester under Vilsmeier-Haack conditions. The in vitro cytotoxicity of the abietic and dehydroabietic acid derivatives against the NCI-60 cancer cell line panel was also studied. The dehydroabietic acid aminopropargyles showed promising antitumor activity against leukemia CCRF-CEM and RPMI-8226 cancer cell lines.
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Tretyakova E. V., Salimova E. V., Parfenova L. V. Synthesis of 7-formyl methyl abietate via Vilsmeier-Haack reaction and cytotoxic activity of abietane diterpene derivatives // AIP Conference Proceedings. 2022. Vol. 2390.
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Tretyakova E. V., Salimova E. V., Parfenova L. V. Synthesis of 7-formyl methyl abietate via Vilsmeier-Haack reaction and cytotoxic activity of abietane diterpene derivatives // AIP Conference Proceedings. 2022. Vol. 2390.
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TY - CPAPER
DO - 10.1063/5.0069202
UR - https://doi.org/10.1063/5.0069202
TI - Synthesis of 7-formyl methyl abietate via Vilsmeier-Haack reaction and cytotoxic activity of abietane diterpene derivatives
T2 - AIP Conference Proceedings
AU - Tretyakova, E V
AU - Salimova, E V
AU - Parfenova, L V
PY - 2022
DA - 2022/02/04
PB - AIP Publishing
VL - 2390
SN - 0094-243X
SN - 1551-7616
ER -
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@inproceedings{2022_Tretyakova,
author = {E V Tretyakova and E V Salimova and L V Parfenova},
title = {Synthesis of 7-formyl methyl abietate via Vilsmeier-Haack reaction and cytotoxic activity of abietane diterpene derivatives},
year = {2022},
volume = {2390},
month = {feb},
publisher = {AIP Publishing}
}