Лаборатория органического синтеза

Development of new methods for modification of natural ecdysteroid molecules and synthesis of cholestane, pregnane and androstane type structures; study of the processes of C-C and C-H bond activation of the steroid molecules using both chemical and physicochemical atom-economic approaches (ultrasound, electrochemistry) for the generation of new unique structures of steroid and non-steroid types, promising as new bioregulators of insect life cycles and chemosensitizing agents that increase the susceptibility of tumor cells to traditional cytostatics.

Development of original approaches and stereoselective methods for the synthesis of propargyl, allene, heterocyclic, etc. derivatives of tepenoids, conjugates with cationic fragments of guanidinium, F16 (4-1H-indol-3-ylvinyl)-N-methylpyridinium iodide), pyridinium, triphenylphosphonium, BODIPY, etc., promising as new anti-HIV agents, drugs with antitumor, antimicrobial and antidiabetic effect.

Development of new potential antibacterial and antitumor drugs based on the tetracyclic triterpenoid fusidic acid by chemo- and stereoselective introduction of amine, amide, ureide, carbamate, hydrazide, polyamine, lactam, nitrile, etc. groups into the triterpene molecule

Development of chemical methods for modification of polysaccharides of animal and plant origin; biocompatible organic coatings for metal implants and theranostic agents, materials for 3D bioprinting and matrix of metal NP synthesis based on polysaccharides and oligopeptides, development of multitarget nanostructured antitumor agents