Open Access
Recent advances in antifungal drug discovery based on polyene macrolide antibiotics
Publication type: Journal Article
Publication date: 2018-12-01
scimago Q1
wos Q1
SJR: 0.811
CiteScore: 12.9
Impact factor: 6.0
ISSN: 0036021X, 14684837
DOI:
10.1070/rcr4841
General Chemistry
Abstract
The review summarizes recent advances in the synthesis of new derivatives of polyene macrolide antibiotics by chemical modification and genetic engineering methods, results of structure – activity relationship studies and progress in the development of effective and safe drug formulations of this class of antibiotics. Attention is focused on structural changes of polyenes, resulting in a significant decrease in toxicity with retention or even enhancement of antifungal activity. Current concepts on the mechanisms of biological action of these antiobiotics in terms of their therapeutic activity and toxicity are considered.
The bibliography includes 77 references.
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Metrics
25
Total citations:
25
Citations from 2025:
2
(8%)
Cite this
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Omelchuk O. A. et al. Recent advances in antifungal drug discovery based on polyene macrolide antibiotics // Russian Chemical Reviews. 2018. Vol. 87. No. 12. pp. 1206-1225.
GOST all authors (up to 50)
Copy
Omelchuk O. A., Tevyashova A., Shchekotikhin A. E. Recent advances in antifungal drug discovery based on polyene macrolide antibiotics // Russian Chemical Reviews. 2018. Vol. 87. No. 12. pp. 1206-1225.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1070/rcr4841
UR - https://doi.org/10.1070/rcr4841
TI - Recent advances in antifungal drug discovery based on polyene macrolide antibiotics
T2 - Russian Chemical Reviews
AU - Omelchuk, Olga A
AU - Tevyashova, Anna
AU - Shchekotikhin, Andrei E
PY - 2018
DA - 2018/12/01
PB - Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
SP - 1206-1225
IS - 12
VL - 87
SN - 0036-021X
SN - 1468-4837
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Omelchuk,
author = {Olga A Omelchuk and Anna Tevyashova and Andrei E Shchekotikhin},
title = {Recent advances in antifungal drug discovery based on polyene macrolide antibiotics},
journal = {Russian Chemical Reviews},
year = {2018},
volume = {87},
publisher = {Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii},
month = {dec},
url = {https://doi.org/10.1070/rcr4841},
number = {12},
pages = {1206--1225},
doi = {10.1070/rcr4841}
}
Cite this
MLA
Copy
Omelchuk, Olga A., et al. “Recent advances in antifungal drug discovery based on polyene macrolide antibiotics.” Russian Chemical Reviews, vol. 87, no. 12, Dec. 2018, pp. 1206-1225. https://doi.org/10.1070/rcr4841.
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