Open Access
,
volume 116
,
issue 14
,
pages 6995-7004
Age-related inflammation triggers skeletal stem/progenitor cell dysfunction
Anne Marie Josephson
1, 2
,
Vivian Bradaschia Correa
1
,
Sooyeon Lee
1
,
Kevin Leclerc
1
,
Karan S Patel
1
,
Emma Muinos Lopez
1
,
Hannah P. Litwa
1
,
Shane S. Neibart
1
,
Manasa Kadiyala
1
,
Madeleine Z Wong
1
,
Matthew M Mizrahi
1
,
Nury L. Yim
1
,
Austin J. Ramme
1
,
Kenneth A. Egol
1
,
Philipp Leucht
1, 2
Publication type: Journal Article
Publication date: 2019-03-20
scimago Q1
wos Q1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
30894483
Multidisciplinary
Abstract
Significance
As we age, our capacity for tissue repair and regeneration in response to injury declines. Accordingly, bone repair is delayed and impaired in older patients. At the cornerstone of bone healing is the skeletal stem/progenitor cell (SSPC), whose function and number diminishes with age. However, the mechanisms driving this decline remain unclear. Here, we identify age-associated inflammation (“inflamm-aging”) as the main culprit of SSPC dysfunction and provide support for a central role of NF-κB as a mediator of inflamm-aging. Our results show that modification of the inflammatory environment may be a translational approach to functionally rejuvenate the aged SSPC, thereby improving the regenerative capacity of the aged skeleton.
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Metrics
179
Total citations:
179
Citations from 2024:
45
(25.14%)
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GOST
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Josephson A. M. et al. Age-related inflammation triggers skeletal stem/progenitor cell dysfunction // Proceedings of the National Academy of Sciences of the United States of America. 2019. Vol. 116. No. 14. pp. 6995-7004.
GOST all authors (up to 50)
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Josephson A. M., Bradaschia Correa V., Lee S., Leclerc K., Patel K. S., Muinos Lopez E., Litwa H. P., Neibart S. S., Kadiyala M., Wong M. Z., Mizrahi M. M., Yim N. L., Ramme A. J., Egol K. A., Leucht P. Age-related inflammation triggers skeletal stem/progenitor cell dysfunction // Proceedings of the National Academy of Sciences of the United States of America. 2019. Vol. 116. No. 14. pp. 6995-7004.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.1810692116
UR - https://doi.org/10.1073/pnas.1810692116
TI - Age-related inflammation triggers skeletal stem/progenitor cell dysfunction
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Josephson, Anne Marie
AU - Bradaschia Correa, Vivian
AU - Lee, Sooyeon
AU - Leclerc, Kevin
AU - Patel, Karan S
AU - Muinos Lopez, Emma
AU - Litwa, Hannah P.
AU - Neibart, Shane S.
AU - Kadiyala, Manasa
AU - Wong, Madeleine Z
AU - Mizrahi, Matthew M
AU - Yim, Nury L.
AU - Ramme, Austin J.
AU - Egol, Kenneth A.
AU - Leucht, Philipp
PY - 2019
DA - 2019/03/20
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 6995-7004
IS - 14
VL - 116
PMID - 30894483
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Josephson,
author = {Anne Marie Josephson and Vivian Bradaschia Correa and Sooyeon Lee and Kevin Leclerc and Karan S Patel and Emma Muinos Lopez and Hannah P. Litwa and Shane S. Neibart and Manasa Kadiyala and Madeleine Z Wong and Matthew M Mizrahi and Nury L. Yim and Austin J. Ramme and Kenneth A. Egol and Philipp Leucht},
title = {Age-related inflammation triggers skeletal stem/progenitor cell dysfunction},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2019},
volume = {116},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {mar},
url = {https://doi.org/10.1073/pnas.1810692116},
number = {14},
pages = {6995--7004},
doi = {10.1073/pnas.1810692116}
}
Cite this
MLA
Copy
Josephson, Anne Marie, et al. “Age-related inflammation triggers skeletal stem/progenitor cell dysfunction.” Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 14, Mar. 2019, pp. 6995-7004. https://doi.org/10.1073/pnas.1810692116.