Open Access
,
volume 112
,
issue 8
,
pages 2401-2406
Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates
Danny Hung-Chieh Chou
1, 2, 3
,
Matthew J Webber
1, 3
,
Benjamin C Tang
1, 3
,
Amy B Lin
1, 3
,
Lavanya S Thapa
1, 3
,
DAVID DENG
1, 3
,
Jonathan V Truong
1, 3
,
Abel B Cortinas
2
,
Robert Langer
1, 2, 3, 4, 5
,
Daniel G. Anderson
1, 2, 3, 4, 5
4
Publication type: Journal Article
Publication date: 2015-02-09
scimago Q1
wos Q1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
25675515
Multidisciplinary
Abstract
Significance
Self-administered insulin is the most important therapeutic to provide control over blood glucose levels for patients with type-1 diabetes. However, standard insulin therapy introduces a number of complications and subsequent issues with control of blood glucose levels. Here, we prepared a derivative of insulin with a molecular switch to provide glucose-mediated activation of the insulin molecule, toward the generation of more autonomous therapy with improved blood glucose control. This modified insulin, when administered in a diabetic mouse model, restores blood glucose levels following a glucose challenge (i.e., a simulated meal) faster than both standard insulin and a clinically used long-lasting insulin derivative.
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Metrics
215
Total citations:
215
Citations from 2024:
34
(15.81%)
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GOST
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Chou D. H. et al. Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates // Proceedings of the National Academy of Sciences of the United States of America. 2015. Vol. 112. No. 8. pp. 2401-2406.
GOST all authors (up to 50)
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Chou D. H., Webber M. J., Tang B. C., Lin A. B., Thapa L. S., DENG D., Truong J. V., Cortinas A. B., Langer R., Anderson D. G. Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates // Proceedings of the National Academy of Sciences of the United States of America. 2015. Vol. 112. No. 8. pp. 2401-2406.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.1424684112
UR - https://doi.org/10.1073/pnas.1424684112
TI - Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Chou, Danny Hung-Chieh
AU - Webber, Matthew J
AU - Tang, Benjamin C
AU - Lin, Amy B
AU - Thapa, Lavanya S
AU - DENG, DAVID
AU - Truong, Jonathan V
AU - Cortinas, Abel B
AU - Langer, Robert
AU - Anderson, Daniel G.
PY - 2015
DA - 2015/02/09
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 2401-2406
IS - 8
VL - 112
PMID - 25675515
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Chou,
author = {Danny Hung-Chieh Chou and Matthew J Webber and Benjamin C Tang and Amy B Lin and Lavanya S Thapa and DAVID DENG and Jonathan V Truong and Abel B Cortinas and Robert Langer and Daniel G. Anderson},
title = {Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2015},
volume = {112},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {feb},
url = {https://doi.org/10.1073/pnas.1424684112},
number = {8},
pages = {2401--2406},
doi = {10.1073/pnas.1424684112}
}
Cite this
MLA
Copy
Chou, Danny Hung-Chieh, et al. “Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates.” Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 8, Feb. 2015, pp. 2401-2406. https://doi.org/10.1073/pnas.1424684112.