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Proceedings of the National Academy of Sciences (PNAS)

Proceedings of the National Academy of Sciences of the United States of America

, том 113 , издание 28 , страницы 7900-7905

Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates

Тип публикации: Journal Article

Дата публикации: 2016-06-28

Связанные публикации

Proceedings of the National Academy of Sciences (PNAS)

Proceedings of the National Academy of Sciences of the United States of America

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SJR: 3.414

CiteScore: 16.5

Impact factor: 9.1

ISSN: 00278424, 10916490

DOI: 10.1073/pnas.1602413113

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PubMed ID: 27357684

Multidisciplinary

Краткое описание

Significance

Functional MRI (fMRI) is 25 years old, yet surprisingly its most common statistical methods have not been validated using real data. Here, we used resting-state fMRI data from 499 healthy controls to conduct 3 million task group analyses. Using this null data with different experimental designs, we estimate the incidence of significant results. In theory, we should find 5% false positives (for a significance threshold of 5%), but instead we found that the most common software packages for fMRI analysis (SPM, FSL, AFNI) can result in false-positive rates of up to 70%. These results question the validity of a number of fMRI studies and may have a large impact on the interpretation of weakly significant neuroimaging results.

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Eklund A. et al. Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates // Proceedings of the National Academy of Sciences of the United States of America. 2016. Vol. 113. No. 28. pp. 7900-7905.

ГОСТ со всеми авторами (до 50) Скопировать

Eklund A., Nichols T. E., Knutsson H. Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates // Proceedings of the National Academy of Sciences of the United States of America. 2016. Vol. 113. No. 28. pp. 7900-7905.

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TY - JOUR

DO - 10.1073/pnas.1602413113

UR - https://doi.org/10.1073/pnas.1602413113

TI - Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates

T2 - Proceedings of the National Academy of Sciences of the United States of America

AU - Eklund, Anders

AU - Nichols, Thomas E.

AU - Knutsson, Hans

PY - 2016

DA - 2016/06/28

PB - Proceedings of the National Academy of Sciences (PNAS)

SP - 7900-7905

IS - 28

VL - 113

PMID - 27357684

SN - 0027-8424

SN - 1091-6490

ER -

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@article{2016_Eklund,

author = {Anders Eklund and Thomas E. Nichols and Hans Knutsson},

title = {Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates},

journal = {Proceedings of the National Academy of Sciences of the United States of America},

year = {2016},

volume = {113},

publisher = {Proceedings of the National Academy of Sciences (PNAS)},

month = {jun},

url = {https://doi.org/10.1073/pnas.1602413113},

number = {28},

pages = {7900--7905},

doi = {10.1073/pnas.1602413113}

}

MLA

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Eklund, Anders, et al. “Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates.” Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 28, Jun. 2016, pp. 7900-7905. https://doi.org/10.1073/pnas.1602413113.